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EFFECT OF IBOPAMINE ON VENTRICULAR REMODELING AFTER EXPERIMENTAL MYOCARDIAL-INFARCTION - A COMPARISON WITH CAPTOPRIL

VANGILST, WH., VANVELDHUISEN, FJ., BUIKEMA, H., DEGRAEFF, PA. & LIE, KI., Jul-1994, In : Journal of Cardiovascular Pharmacology. 24, 1, p. 171-174 4 p.

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Remodeling after myocardial infarction (MI) is influenced not only by hemodynamic but possibly by neurohumoral factors as well. Ibopamine is an orally active dopamine agonist (DA) with both hemodynamic and neurohumoral properties in humans. The latter property prevails in rats. To study the dose-dependent effect of ibopamine on myocardial remodeling and compare it with the effect of captopril, we randomized rats with (n = 27) or without (n = 27) experimental MI to captopril (25 mg/ kg/day), low-dose ibopamine (10 mg/kg/day), high-dose ibopamine (30 mg/kg/day), or no treatment. After 8-week treatment, hearts were isolated and left ventricular (LV) function, LV cavity volume, and infarct size (IS) were evaluated. Both ibopamine and captopril significantly reduced plasma norepinephrine (NE) levels in rats with MI. was significantly reduced as compared with that of controls. IS was reduced in all three active treatment groups as compared with untreated rats. LV cavity volume was significantly increased in untreated rats with MI as compared with controls. This dilatation was attenuated by both ibopamine and captopril. Ibopamine, comparable to captopril, administered early after coronary ligation reduced IS and subsequent ventricular dilatation, resulting in preservation of cardiac function in this rat model. This observation suggests a major role for neurohumoral activation in the process of remodeling.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalJournal of Cardiovascular Pharmacology
Volume24
Issue number1
Publication statusPublished - Jul-1994

    Keywords

  • MYOCARDIAL INFARCTION, MYOCARDIAL REMODELING, HEMODYNAMICS, NEUROHUMORAL ACTIVATION, IBOPAMINE, CAPTOPRIL, RAT HEARTS

ID: 6390004