Publication

Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study

Oosterhaven, J. A. F., Voorberg, A. N., Romeijn, G. L. E., de Bruin-Weller, M. S. & Schuttelaar, M. L. A., Aug-2019, In : The Journal of dermatology. 46, 8, p. 680-685 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Oosterhaven, J. A. F., Voorberg, A. N., Romeijn, G. L. E., de Bruin-Weller, M. S., & Schuttelaar, M. L. A. (2019). Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study. The Journal of dermatology, 46(8), 680-685. https://doi.org/10.1111/1346-8138.14982

Author

Oosterhaven, Jart A F ; Voorberg, Angelique N ; Romeijn, Geertruida L E ; de Bruin-Weller, Marjolein S ; Schuttelaar, Marie L A. / Effect of dupilumab on hand eczema in patients with atopic dermatitis : An observational study. In: The Journal of dermatology. 2019 ; Vol. 46, No. 8. pp. 680-685.

Harvard

Oosterhaven, JAF, Voorberg, AN, Romeijn, GLE, de Bruin-Weller, MS & Schuttelaar, MLA 2019, 'Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study', The Journal of dermatology, vol. 46, no. 8, pp. 680-685. https://doi.org/10.1111/1346-8138.14982

Standard

Effect of dupilumab on hand eczema in patients with atopic dermatitis : An observational study. / Oosterhaven, Jart A F; Voorberg, Angelique N; Romeijn, Geertruida L E; de Bruin-Weller, Marjolein S; Schuttelaar, Marie L A.

In: The Journal of dermatology, Vol. 46, No. 8, 08.2019, p. 680-685.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Oosterhaven JAF, Voorberg AN, Romeijn GLE, de Bruin-Weller MS, Schuttelaar MLA. Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study. The Journal of dermatology. 2019 Aug;46(8):680-685. https://doi.org/10.1111/1346-8138.14982


BibTeX

@article{68a1b52a36304905a0d1a8fbfc81bab2,
title = "Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study",
abstract = "Systemic treatment options for chronic hand eczema are limited. Dupilumab is used in atopic dermatitis (AD) but is not licensed for (isolated) hand eczema. In this observational prospective study we aimed to determine the response of hand eczema to dupilumab in patients with AD. Adult patients with hand eczema and AD received dupilumab s.c. at a 600 mg loading dose, followed by 300 mg every 2 weeks. Primary outcome was a minimum improvement of 75{\%} on the Hand Eczema Severity Index after 16 weeks (HECSI-75). Secondary outcomes were severity, measured using the Photographic guide; quality of life improvement as patient-reported outcome, measured using the Dermatology Life Quality Index (DLQI); and AD severity, measured using the Eczema Area and Severity Index (EASI). Forty-seven patients were included (32 males; mean age, 45 years). HECSI-75 was achieved by 28 (60{\%}). Mean HECSI score reduction was 49.2 points (range, 0-164; 95{\%} within-subject confidence interval, 46.4-52.0), which was already significantly decreased after 4 weeks (P < 0.001). DLQI score mean improvement was 8.8 points (standard deviation [SD], 6.0) or 70.0{\%} decrease (SD, 26.4) (P < 0.001). Eighteen patients (38{\%}) were classified as responders on the Photographic guide. There was no difference in response between chronic fissured and recurrent vesicular clinical subtypes. Similar percentages of patients achieving EASI-75 and HECSI-75 were seen after 16 weeks. In conclusion, this study shows a favorable response of hand eczema to dupilumab in patients with AD. This raises the question whether a response will also be seen in isolated hand eczema.",
author = "Oosterhaven, {Jart A F} and Voorberg, {Angelique N} and Romeijn, {Geertruida L E} and {de Bruin-Weller}, {Marjolein S} and Schuttelaar, {Marie L A}",
note = "{\circledC} 2019 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.",
year = "2019",
month = "8",
doi = "10.1111/1346-8138.14982",
language = "English",
volume = "46",
pages = "680--685",
journal = "The Journal of dermatology",
issn = "0385-2407",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - Effect of dupilumab on hand eczema in patients with atopic dermatitis

T2 - An observational study

AU - Oosterhaven, Jart A F

AU - Voorberg, Angelique N

AU - Romeijn, Geertruida L E

AU - de Bruin-Weller, Marjolein S

AU - Schuttelaar, Marie L A

N1 - © 2019 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.

PY - 2019/8

Y1 - 2019/8

N2 - Systemic treatment options for chronic hand eczema are limited. Dupilumab is used in atopic dermatitis (AD) but is not licensed for (isolated) hand eczema. In this observational prospective study we aimed to determine the response of hand eczema to dupilumab in patients with AD. Adult patients with hand eczema and AD received dupilumab s.c. at a 600 mg loading dose, followed by 300 mg every 2 weeks. Primary outcome was a minimum improvement of 75% on the Hand Eczema Severity Index after 16 weeks (HECSI-75). Secondary outcomes were severity, measured using the Photographic guide; quality of life improvement as patient-reported outcome, measured using the Dermatology Life Quality Index (DLQI); and AD severity, measured using the Eczema Area and Severity Index (EASI). Forty-seven patients were included (32 males; mean age, 45 years). HECSI-75 was achieved by 28 (60%). Mean HECSI score reduction was 49.2 points (range, 0-164; 95% within-subject confidence interval, 46.4-52.0), which was already significantly decreased after 4 weeks (P < 0.001). DLQI score mean improvement was 8.8 points (standard deviation [SD], 6.0) or 70.0% decrease (SD, 26.4) (P < 0.001). Eighteen patients (38%) were classified as responders on the Photographic guide. There was no difference in response between chronic fissured and recurrent vesicular clinical subtypes. Similar percentages of patients achieving EASI-75 and HECSI-75 were seen after 16 weeks. In conclusion, this study shows a favorable response of hand eczema to dupilumab in patients with AD. This raises the question whether a response will also be seen in isolated hand eczema.

AB - Systemic treatment options for chronic hand eczema are limited. Dupilumab is used in atopic dermatitis (AD) but is not licensed for (isolated) hand eczema. In this observational prospective study we aimed to determine the response of hand eczema to dupilumab in patients with AD. Adult patients with hand eczema and AD received dupilumab s.c. at a 600 mg loading dose, followed by 300 mg every 2 weeks. Primary outcome was a minimum improvement of 75% on the Hand Eczema Severity Index after 16 weeks (HECSI-75). Secondary outcomes were severity, measured using the Photographic guide; quality of life improvement as patient-reported outcome, measured using the Dermatology Life Quality Index (DLQI); and AD severity, measured using the Eczema Area and Severity Index (EASI). Forty-seven patients were included (32 males; mean age, 45 years). HECSI-75 was achieved by 28 (60%). Mean HECSI score reduction was 49.2 points (range, 0-164; 95% within-subject confidence interval, 46.4-52.0), which was already significantly decreased after 4 weeks (P < 0.001). DLQI score mean improvement was 8.8 points (standard deviation [SD], 6.0) or 70.0% decrease (SD, 26.4) (P < 0.001). Eighteen patients (38%) were classified as responders on the Photographic guide. There was no difference in response between chronic fissured and recurrent vesicular clinical subtypes. Similar percentages of patients achieving EASI-75 and HECSI-75 were seen after 16 weeks. In conclusion, this study shows a favorable response of hand eczema to dupilumab in patients with AD. This raises the question whether a response will also be seen in isolated hand eczema.

U2 - 10.1111/1346-8138.14982

DO - 10.1111/1346-8138.14982

M3 - Article

C2 - 31187925

VL - 46

SP - 680

EP - 685

JO - The Journal of dermatology

JF - The Journal of dermatology

SN - 0385-2407

IS - 8

ER -

ID: 85686818