Een neurodegeneratieve tragedie. Pathogenese en therapie van amyotrofische laterale sclerose

Bongaerts, K. H. & Loonen, A. J. M., 29-Jun-2001, In : Pharmaceutisch Weekblad. 136, 26, p. 928-934 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • K.H. Bongaerts
  • A.J.M. Loonen
Amyotrophic lateral sclerosis(ALS) is a chronic progressive neurological disorder characterised by degeneration of upper and lower motor neurons. Patients suffer from paresis and atrophy of the affected muscle groups and changes of myotactic reflexes. They usually pass away within 3-5 years, although some may live for over 10 years. An unequivocal pathogenetic mechanism has not yet been identified. Putative causes are found in a dysfunction of the glutamate transport system and/or a in change of the activity of the Cu/Zn superoxide dismutase. At present only rilusole is available to treat ALS. For the time being, a symptomatic treatment is the only therapy we have to offer in addition. Promising are the effects of certain neurotrophic factors in mice.
Translated title of the contributionA neurodegenerative tragedy. Pathogenesis and treatment of amyotrophic lateral sclerosis
Original languageDutch
Pages (from-to)928-934
Number of pages7
JournalPharmaceutisch Weekblad
Issue number26
Publication statusPublished - 29-Jun-2001


  • copper zinc superoxide dismutase, glutamate transporter, riluzole, amyotrophic lateral sclerosis, article, degenerative disease, disease course, human, muscle atrophy, myotatic reflex, paresis, pathogenesis

ID: 17492889