Publication

Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods

Triadyaksa, P., Kuijpers, D., Akinci D'Antonoli, T., Overbosch, J., Rook, M., van Swieten, J. M., Oudkerk, M. & Sijens, P. E., Jan-2020, In : European Radiology. 30, 1, p. 652-662 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Triadyaksa, P., Kuijpers, D., Akinci D'Antonoli, T., Overbosch, J., Rook, M., van Swieten, J. M., ... Sijens, P. E. (2020). Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods. European Radiology, 30(1), 652-662. https://doi.org/10.1007/s00330-019-06364-9

Author

Triadyaksa, Pandji ; Kuijpers, Dirkjan ; Akinci D'Antonoli, Tugba ; Overbosch, Jelle ; Rook, Mieneke ; van Swieten, J Martijn ; Oudkerk, Matthijs ; Sijens, Paul E. / Early detection of heart function abnormality by native T1 : a comparison of two T1 quantification methods. In: European Radiology. 2020 ; Vol. 30, No. 1. pp. 652-662.

Harvard

Triadyaksa, P, Kuijpers, D, Akinci D'Antonoli, T, Overbosch, J, Rook, M, van Swieten, JM, Oudkerk, M & Sijens, PE 2020, 'Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods', European Radiology, vol. 30, no. 1, pp. 652-662. https://doi.org/10.1007/s00330-019-06364-9

Standard

Early detection of heart function abnormality by native T1 : a comparison of two T1 quantification methods. / Triadyaksa, Pandji; Kuijpers, Dirkjan; Akinci D'Antonoli, Tugba; Overbosch, Jelle; Rook, Mieneke; van Swieten, J Martijn; Oudkerk, Matthijs; Sijens, Paul E.

In: European Radiology, Vol. 30, No. 1, 01.2020, p. 652-662.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Triadyaksa P, Kuijpers D, Akinci D'Antonoli T, Overbosch J, Rook M, van Swieten JM et al. Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods. European Radiology. 2020 Jan;30(1):652-662. https://doi.org/10.1007/s00330-019-06364-9


BibTeX

@article{9ed74b77dbc9432389b2fa69b037fa7b,
title = "Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods",
abstract = "Objective To compare the robustness of native T1 mapping using mean and median pixel-wise quantification methods. Methods Fifty-seven consecutive patients without overt signs of heart failure were examined in clinical routine for suspicion of cardiomyopathy. MRI included the acquisition of native T1 maps by a motion-corrected modified Look-Locker inversion recovery sequence at 1.5 T. Heart function status according to four established volumetric left ventricular (LV) cardio MRI parameter thresholds was used for retrospective separation into subgroups of normal (n = 26) or abnormal heart function (n = 31). Statistical normality of pixel-wise T1 was tested on each myocardial segment and mean and median segmental T1 values were assessed. Results Segments with normally distributed pixel-wise T1 (57/58{\%}) showed no difference between mean and median quantification in either patient group, while differences were highly significant (p <0.001) for the respective 43/42{\%} non-normally distributed segments. Heart function differentiation between two patient groups was significant in 14 myocardial segments (p <0.001-0.040) by median quantification compared with six (p <0.001-0.042) by using the mean. The differences by median quantification were observed between the native T1 values of the three coronary artery territories of normal heart function patients (p = 0.023) and insignificantly in the abnormal patients (p = 0.053). Conclusion Median quantification increases the robustness of myocardial native T1 definition, regardless of statistical normality of the data. Compared with the currently prevailing method of mean quantification, differentiation between LV segments and coronary artery territories is better and allows for earlier detection of heart function impairment.",
keywords = "Magnetic resonance imaging, Myocardium, Cardiomyopathies, Statistical distribution, MAGNETIC-RESONANCE, MYOCARDIUM, T-1, REPRODUCIBILITY, PRECISION, ACCURACY, DISEASE, VALUES, REMOTE, AGE",
author = "Pandji Triadyaksa and Dirkjan Kuijpers and {Akinci D'Antonoli}, Tugba and Jelle Overbosch and Mieneke Rook and {van Swieten}, {J Martijn} and Matthijs Oudkerk and Sijens, {Paul E}",
year = "2020",
month = "1",
doi = "10.1007/s00330-019-06364-9",
language = "English",
volume = "30",
pages = "652--662",
journal = "European Radiology",
issn = "0938-7994",
publisher = "SPRINGER",
number = "1",

}

RIS

TY - JOUR

T1 - Early detection of heart function abnormality by native T1

T2 - a comparison of two T1 quantification methods

AU - Triadyaksa, Pandji

AU - Kuijpers, Dirkjan

AU - Akinci D'Antonoli, Tugba

AU - Overbosch, Jelle

AU - Rook, Mieneke

AU - van Swieten, J Martijn

AU - Oudkerk, Matthijs

AU - Sijens, Paul E

PY - 2020/1

Y1 - 2020/1

N2 - Objective To compare the robustness of native T1 mapping using mean and median pixel-wise quantification methods. Methods Fifty-seven consecutive patients without overt signs of heart failure were examined in clinical routine for suspicion of cardiomyopathy. MRI included the acquisition of native T1 maps by a motion-corrected modified Look-Locker inversion recovery sequence at 1.5 T. Heart function status according to four established volumetric left ventricular (LV) cardio MRI parameter thresholds was used for retrospective separation into subgroups of normal (n = 26) or abnormal heart function (n = 31). Statistical normality of pixel-wise T1 was tested on each myocardial segment and mean and median segmental T1 values were assessed. Results Segments with normally distributed pixel-wise T1 (57/58%) showed no difference between mean and median quantification in either patient group, while differences were highly significant (p <0.001) for the respective 43/42% non-normally distributed segments. Heart function differentiation between two patient groups was significant in 14 myocardial segments (p <0.001-0.040) by median quantification compared with six (p <0.001-0.042) by using the mean. The differences by median quantification were observed between the native T1 values of the three coronary artery territories of normal heart function patients (p = 0.023) and insignificantly in the abnormal patients (p = 0.053). Conclusion Median quantification increases the robustness of myocardial native T1 definition, regardless of statistical normality of the data. Compared with the currently prevailing method of mean quantification, differentiation between LV segments and coronary artery territories is better and allows for earlier detection of heart function impairment.

AB - Objective To compare the robustness of native T1 mapping using mean and median pixel-wise quantification methods. Methods Fifty-seven consecutive patients without overt signs of heart failure were examined in clinical routine for suspicion of cardiomyopathy. MRI included the acquisition of native T1 maps by a motion-corrected modified Look-Locker inversion recovery sequence at 1.5 T. Heart function status according to four established volumetric left ventricular (LV) cardio MRI parameter thresholds was used for retrospective separation into subgroups of normal (n = 26) or abnormal heart function (n = 31). Statistical normality of pixel-wise T1 was tested on each myocardial segment and mean and median segmental T1 values were assessed. Results Segments with normally distributed pixel-wise T1 (57/58%) showed no difference between mean and median quantification in either patient group, while differences were highly significant (p <0.001) for the respective 43/42% non-normally distributed segments. Heart function differentiation between two patient groups was significant in 14 myocardial segments (p <0.001-0.040) by median quantification compared with six (p <0.001-0.042) by using the mean. The differences by median quantification were observed between the native T1 values of the three coronary artery territories of normal heart function patients (p = 0.023) and insignificantly in the abnormal patients (p = 0.053). Conclusion Median quantification increases the robustness of myocardial native T1 definition, regardless of statistical normality of the data. Compared with the currently prevailing method of mean quantification, differentiation between LV segments and coronary artery territories is better and allows for earlier detection of heart function impairment.

KW - Magnetic resonance imaging

KW - Myocardium

KW - Cardiomyopathies

KW - Statistical distribution

KW - MAGNETIC-RESONANCE

KW - MYOCARDIUM

KW - T-1

KW - REPRODUCIBILITY

KW - PRECISION

KW - ACCURACY

KW - DISEASE

KW - VALUES

KW - REMOTE

KW - AGE

U2 - 10.1007/s00330-019-06364-9

DO - 10.1007/s00330-019-06364-9

M3 - Article

C2 - 31410603

VL - 30

SP - 652

EP - 662

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 1

ER -

ID: 94199785