Publication

Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury

Spikman, J. M., Timmerman, M. E., Coers, A. & van der Naalt, J., 1-Jan-2016, In : Journal of Neurotrauma. 33, 1, p. 22-28 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Spikman, J. M., Timmerman, M. E., Coers, A., & van der Naalt, J. (2016). Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury. Journal of Neurotrauma, 33(1), 22-28. https://doi.org/10.1089/neu.2014.3788

Author

Spikman, Jacoba M. ; Timmerman, Marieke E. ; Coers, Annemieke ; van der Naalt, Joukje. / Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury. In: Journal of Neurotrauma. 2016 ; Vol. 33, No. 1. pp. 22-28.

Harvard

Spikman, JM, Timmerman, ME, Coers, A & van der Naalt, J 2016, 'Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury', Journal of Neurotrauma, vol. 33, no. 1, pp. 22-28. https://doi.org/10.1089/neu.2014.3788

Standard

Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury. / Spikman, Jacoba M.; Timmerman, Marieke E.; Coers, Annemieke; van der Naalt, Joukje.

In: Journal of Neurotrauma, Vol. 33, No. 1, 01.01.2016, p. 22-28.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Spikman JM, Timmerman ME, Coers A, van der Naalt J. Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury. Journal of Neurotrauma. 2016 Jan 1;33(1):22-28. https://doi.org/10.1089/neu.2014.3788


BibTeX

@article{c5712a3c84d340f99f6c62173abda1b6,
title = "Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury",
abstract = "Behavioral problems are serious consequences of moderate to severe traumatic brain injury (TBI) and have a negative impact on outcome. There may be two types: neurobehavioral problems, manifesting as inadequate social behavior resulting from prefrontal system damage, and affective behavioral problems, resulting from emotional distress as a reaction to the brain injury. In the present study we investigated whether these two types of behavioral problems, as indicated by proxies, could be distinguished in a group of chronic TBI patients and whether early indicators of prefrontal damage on imaging could predict long-term neurobehavioral problems. Computed tomography (CT) imaging data on admission were used to identify frontal lesions. Three hundred twenty-three moderate to severe TBI survivors received 2 to 16 years post-trauma an aftercare survey with seven questions asking for changes in behavior and affect, presented both to patients and their proxies. One hundred eighty-six patients (59{\%}) answered the behavioral questions; 42{\%} had frontal lesions on CT. Ordinal common factor analysis on proxy scores yielded two factors, with behavior and affective items clearly separated and the anger item mediocre related to both factors. Three scales were created: Behavior, Affective and Anger. Frontal patients scored significantly higher on the Behavior and Anger scales. Logistic regression analysis showed a fourfold increase of long-term neurobehavioral problems in patients with frontal lesions. Long-term neurobehavioral problems were significantly correlated to one-year outcome and return to work in the long term. We conclude that in patients with moderate to severe TBI neurobehavioral and affective problems can be distinguished. Early CT frontal abnormalities predict long-term neurobehavioral problems, but not affective problems.",
keywords = "affective problems, CT, frontal abnormalities, neurobehavioral problems, traumatic brain injury (TBI), II PSYCHIATRIC-DISORDERS, SEVERE HEAD-INJURY, FOLLOW-UP, AXIS-I, MRI FINDINGS, IMPAIRMENTS, DEPRESSION, PSYCHOPATHOLOGY, INDIVIDUALS, DEFICITS",
author = "Spikman, {Jacoba M.} and Timmerman, {Marieke E.} and Annemieke Coers and {van der Naalt}, Joukje",
year = "2016",
month = "1",
day = "1",
doi = "10.1089/neu.2014.3788",
language = "English",
volume = "33",
pages = "22--28",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "MARY ANN LIEBERT, INC",
number = "1",

}

RIS

TY - JOUR

T1 - Early Computed Tomography Frontal Abnormalities Predict Long-Term Neurobehavioral Problems But Not Affective Problems after Moderate to Severe Traumatic Brain Injury

AU - Spikman, Jacoba M.

AU - Timmerman, Marieke E.

AU - Coers, Annemieke

AU - van der Naalt, Joukje

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Behavioral problems are serious consequences of moderate to severe traumatic brain injury (TBI) and have a negative impact on outcome. There may be two types: neurobehavioral problems, manifesting as inadequate social behavior resulting from prefrontal system damage, and affective behavioral problems, resulting from emotional distress as a reaction to the brain injury. In the present study we investigated whether these two types of behavioral problems, as indicated by proxies, could be distinguished in a group of chronic TBI patients and whether early indicators of prefrontal damage on imaging could predict long-term neurobehavioral problems. Computed tomography (CT) imaging data on admission were used to identify frontal lesions. Three hundred twenty-three moderate to severe TBI survivors received 2 to 16 years post-trauma an aftercare survey with seven questions asking for changes in behavior and affect, presented both to patients and their proxies. One hundred eighty-six patients (59%) answered the behavioral questions; 42% had frontal lesions on CT. Ordinal common factor analysis on proxy scores yielded two factors, with behavior and affective items clearly separated and the anger item mediocre related to both factors. Three scales were created: Behavior, Affective and Anger. Frontal patients scored significantly higher on the Behavior and Anger scales. Logistic regression analysis showed a fourfold increase of long-term neurobehavioral problems in patients with frontal lesions. Long-term neurobehavioral problems were significantly correlated to one-year outcome and return to work in the long term. We conclude that in patients with moderate to severe TBI neurobehavioral and affective problems can be distinguished. Early CT frontal abnormalities predict long-term neurobehavioral problems, but not affective problems.

AB - Behavioral problems are serious consequences of moderate to severe traumatic brain injury (TBI) and have a negative impact on outcome. There may be two types: neurobehavioral problems, manifesting as inadequate social behavior resulting from prefrontal system damage, and affective behavioral problems, resulting from emotional distress as a reaction to the brain injury. In the present study we investigated whether these two types of behavioral problems, as indicated by proxies, could be distinguished in a group of chronic TBI patients and whether early indicators of prefrontal damage on imaging could predict long-term neurobehavioral problems. Computed tomography (CT) imaging data on admission were used to identify frontal lesions. Three hundred twenty-three moderate to severe TBI survivors received 2 to 16 years post-trauma an aftercare survey with seven questions asking for changes in behavior and affect, presented both to patients and their proxies. One hundred eighty-six patients (59%) answered the behavioral questions; 42% had frontal lesions on CT. Ordinal common factor analysis on proxy scores yielded two factors, with behavior and affective items clearly separated and the anger item mediocre related to both factors. Three scales were created: Behavior, Affective and Anger. Frontal patients scored significantly higher on the Behavior and Anger scales. Logistic regression analysis showed a fourfold increase of long-term neurobehavioral problems in patients with frontal lesions. Long-term neurobehavioral problems were significantly correlated to one-year outcome and return to work in the long term. We conclude that in patients with moderate to severe TBI neurobehavioral and affective problems can be distinguished. Early CT frontal abnormalities predict long-term neurobehavioral problems, but not affective problems.

KW - affective problems

KW - CT

KW - frontal abnormalities

KW - neurobehavioral problems

KW - traumatic brain injury (TBI)

KW - II PSYCHIATRIC-DISORDERS

KW - SEVERE HEAD-INJURY

KW - FOLLOW-UP

KW - AXIS-I

KW - MRI FINDINGS

KW - IMPAIRMENTS

KW - DEPRESSION

KW - PSYCHOPATHOLOGY

KW - INDIVIDUALS

KW - DEFICITS

U2 - 10.1089/neu.2014.3788

DO - 10.1089/neu.2014.3788

M3 - Article

VL - 33

SP - 22

EP - 28

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 1

ER -

ID: 24163819