Publication

Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act

Lubberts, S., Meijer, C., Demaria, M. & Gietema, J. A., Jul-2020, In : Critical Reviews in Oncology/Hematology. 151, 8 p., 102963.

Research output: Contribution to journalReview articleAcademicpeer-review

Treatment of testicular cancer (TC) has an exceptionally high success rate compared to other cancer types; even in case of metastasized disease, 80-90 % of TC patients can be cured. Consequently, attention has been drawn to a potential downside of this treatment success: late adverse treatment effects such as the accelerated development of otherwise age-associated features like cardiovascular disease and second malignancies. Underlying mechanisms are poorly understood. Emerging data suggest that cytotoxic treatment induces cellular senescence, resulting in secretion of inflammatory factors contributing to this early ageing phenotype. Molecular and cellular characterization of this early ageing will enhance understanding the pathogenesis of TC treatment-induced morbidity and contribute to better recognition and prevention of late effects. In this review, we describe clinical manifestations of the early ageing phenotype among TC survivors, and subsequently focus on potential underlying mechanisms. We discuss the clinical implications and describe perspectives for future research and intervention strategies.

Original languageEnglish
Article number102963
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume151
Early online date2020
Publication statusPublished - Jul-2020

    Keywords

  • Cisplatin, Late effects, Senescence, Testicular cancer, LONG-TERM SURVIVORS, METABOLIC SYNDROME, TELOMERE LENGTH, DNA-DAMAGE, CARDIOVASCULAR-DISEASE, COGNITIVE IMPAIRMENT, HEART-DISEASE, RISK-FACTORS, CHEMOTHERAPY, BLEOMYCIN

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