Dysregulation of NF-kB in glandular epithelial cells results in Sjogren's-like features

Wang, X., Shaalan, A., Liefers, S., Coudenys, J., Elewaut, D., Proctor, G. B., Bootsma, H., Kroese, F. G. M. & Pringle, S., 1-Aug-2018, In : PLoS ONE. 13, 8, 9 p., 0200212.

Research output: Contribution to journalArticleAcademicpeer-review

The autoimmune disease primary Sjogren's syndrome (pSS) is characterized by hypofunction of the salivary glands (SGs), the cause of which is not correlated to lymphocytic SG infiltration, as prevailing dogma often states. We knocked out the NF-kappa B proinflammatory pathway inhibitor A20 in keratin14(+) epithelial cells, to investigate if immune activated epithelial cells are capable of initiating pSS SG hallmarks. We show that immune activated epithelial cells can cause T cell dominated leukocytic infiltration and immune foci development of the SGs, reflecting the early clinical picture. Infiltrating leukocytes invaded striated ducts, similar to early stage lymphoepithelial lesions observed clinically. Expression of proinflammatory cyto-/chemokines IFN gamma TNF alpha, IL-6, CXCL10 and CXCL13 increased in A20(-/-) SGs, and functionally both volume and mucin 10 content of whole stimulated saliva from A20(-/-) mice was significantly reduced. Epithelial cells may therefore represent the initial trigger for pSS SG pathologies, as opposed to simple reactionaries to pre-existing stimuli.

Original languageEnglish
Article number0200212
Number of pages9
JournalPLoS ONE
Issue number8
Publication statusPublished - 1-Aug-2018



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