Publication

Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

Piters, W. A. A. D. S., Huijskens, E. G. W., Wyllie, A. L., Biesbroek, G., van den Bergh, M. R., Veenhoven, R. H., Wang, X., Trzcinski, K., Bonten, M. J., Rossen, J. W. A., Sanders, E. A. M. & Bogaert, D., Jan-2016, In : The ISME journal. 10, 1, p. 97-108 12 p.

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  • Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

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DOI

  • Wouter A. A. de Steenhuijsen Piters
  • Elisabeth G. W. Huijskens
  • Anne L. Wyllie
  • Giske Biesbroek
  • Menno R. van den Bergh
  • Reinier H. Veenhoven
  • Xinhui Wang
  • Krzysztof Trzcinski
  • Marc J. Bonten
  • John W. A. Rossen
  • Elisabeth A. M. Sanders
  • Debby Bogaert

Bacterial pneumonia is a major cause of morbidity and mortality in elderly. We hypothesize that dysbiosis between regular residents of the upper respiratory tract (URT) microbiome, that is balance between commensals and potential pathogens, is involved in pathogen overgrowth and consequently disease. We compared oropharyngeal microbiota of elderly pneumonia patients (n=100) with healthy elderly (n=91) by 16S-rRNA-based sequencing and verified our findings in young adult pneumonia patients (n=27) and young healthy adults (n=187). Microbiota profiles differed significantly between elderly pneumonia patients and healthy elderly (PERMANOVA, P

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalThe ISME journal
Volume10
Issue number1
Publication statusPublished - Jan-2016

    Keywords

  • COMMUNITY-ACQUIRED PNEUMONIA, DISEASE, IDENTIFICATION, INFECTIONS, PATHOGENS, CHILDREN, SAMPLES, PH

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