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Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry

Li, J., Nowak, P. & Otto, S., 26-Jun-2013, In : Journal of the American Chemical Society. 135, 25, p. 9222-9239 18 p.

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DOI

Dynamic combinatorial chemistry (DCC) is a subset of combinatorial chemistry where the library members interconvert continuously by exchanging building blocks with each other. Dynamic combinatorial libraries (DCLs) are powerful tools for discovering the unexpected and have given rise to many fascinating molecules, ranging from interlocked structures to self-replicators. Furthermore, dynamic combinatorial molecular networks can produce emergent properties at systems level, which provide exciting new opportunities in systems chemistry. In this perspective we will highlight some new methodologies in this field and analyze selected examples of DCLs that are under thermodynamic control, leading to synthetic receptors, catalytic systems, and complex self-assembled supramolecular architectures. Also reviewed are extensions of the principles of DCC to systems that are not at equilibrium and may therefore harbor richer functional behavior. Examples include self-replication and molecular machines.

Original languageEnglish
Pages (from-to)9222-9239
Number of pages18
JournalJournal of the American Chemical Society
Volume135
Issue number25
Publication statusPublished - 26-Jun-2013

    Keywords

  • SURFACE-INITIATED POLYMERIZATION, SELF-ASSEMBLED MONOLAYERS, HOST-GUEST BINDING, COVALENT CHEMISTRY, SYNTHETIC RECEPTOR, AQUEOUS-SOLUTION, SUPRAMOLECULAR CHEMISTRY, CARBOHYDRATE-RECOGNITION, NONCOVALENT INTERACTIONS, NUCLEOPHILIC CATALYSIS

ID: 5902282