Publication

Dynamic cerebral autoregulation estimates derived from near infrared spectroscopy and transcranial Doppler are similar after correction for transit time and blood flow and blood volume oscillations

Elting, J. W. J., Tas, J., Aries, M. J. H., Czosnyka, M. & Maurits, N. M., Jan-2020, In : Journal of Cerebral Blood Flow and Metabolism. 40, 1, p. 135-149 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

We analysed mean arterial blood pressure, cerebral blood flow velocity, oxygenated haemoglobin and deoxygenated haemoglobin signals to estimate dynamic cerebral autoregulation. We compared macrovascular (mean arterial blood pressure-cerebral blood flow velocity) and microvascular (oxygenated haemoglobin-deoxygenated haemoglobin) dynamic cerebral autoregulation estimates during three different conditions: rest, mild hypocapnia and hypercapnia. Microvascular dynamic cerebral autoregulation estimates were created by introducing the constant time lag plus constant phase shift model, which enables correction for transit time, blood flow and blood volume oscillations (TT-BF/BV correction). After TT-BF/BV correction, a significant agreement between mean arterial blood pressure-cerebral blood flow velocity and oxygenated haemoglobin-deoxygenated haemoglobin phase differences in the low frequency band was found during rest (left: intraclass correlation=0.6, median phase difference 29.5 degrees vs. 30.7 degrees, right: intraclass correlation=0.56, median phase difference 32.6 degrees vs. 39.8 degrees) and mild hypocapnia (left: intraclass correlation=0.73, median phase difference 48.6 degrees vs. 43.3 degrees, right: intraclass correlation=0.70, median phase difference 52.1 degrees vs. 61.8 degrees). During hypercapnia, the mean transit time decreased and blood volume oscillations became much more prominent, except for very low frequencies. The transit time related to blood flow oscillations was remarkably stable during all conditions. We conclude that non-invasive microvascular dynamic cerebral autoregulation estimates are similar to macrovascular dynamic cerebral autoregulation estimates, after TT-BF/BV correction is applied. These findings may increase the feasibility of non-invasive continuous autoregulation monitoring and guided therapy in clinical situations.

Original languageEnglish
Pages (from-to)135-149
Number of pages15
JournalJournal of Cerebral Blood Flow and Metabolism
Volume40
Issue number1
Early online date24-Oct-2018
Publication statusPublished - Jan-2020
EventJournal-of-Cerebral-Blood-Flow-and-Metabolism (JCBFM) Symposium at International Symposium on Cerebral Blood Flow, Metabolism and Function (BRAIN) - Yokohama, Japan
Duration: 7-Jul-2019 → …

Event

Journal-of-Cerebral-Blood-Flow-and-Metabolism (JCBFM) Symposium at International Symposium on Cerebral Blood Flow, Metabolism and Function (BRAIN)

07/07/2019 → …

Yokohama, Japan

Event: Conference

    Keywords

  • Dynamic cerebral autoregulation, transcranial Doppler, near infrared spectroscopy, group delay, microvascular transit time, LOW-FREQUENCY OSCILLATIONS, HETEROGENEITY CTH, HEMODYNAMICS, HYPERCAPNIA, METABOLISM, HYPOCAPNIA, CO2

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