Publication

Dry powder inhalation: past, present and future

de Boer, A., Hagedoorn, P., Hoppentocht, M., Buttini, F., Grasmeijer, F. & Frijlink, H. W., Apr-2017, In : Expert Opinion on Drug Delivery. 14, 4, p. 499-512 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

INTRODUCTION: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers.

AREAS COVERED: The consequences of the choices made for early DPI development with respect of efficacy, production costs and safety and the tremendous amount of energy put into understanding and controlling the dispersion performance of adhesive mixtures are discussed. Also newly developed particle manufacturing and powder formulation processes are presented as well as the challenges, objectives, and new tools available for future DPI design.

EXPERT OPINION: Improved inhaler design is desired to make DPIs for future applications cost-effective and safe. With an increasing interest in high dose drug delivery, vaccination and systemic delivery via the lungs, innovative formulation technologies alone may not be sufficient. Safety is served by increasing patient adherence to the therapy, minimizing the use of unnecessary excipients and designing simple and self-intuitive inhalers, which give good feedback to the patient about the inhalation maneuver. For some applications, like vaccination and delivery of hygroscopic formulations, disposable inhalers may be preferred.

Original languageEnglish
Pages (from-to)499-512
Number of pages14
JournalExpert Opinion on Drug Delivery
Volume14
Issue number4
Early online date30-Aug-2016
Publication statusPublished - Apr-2017

    Keywords

  • Adhesive mixtures, dry powder inhaler design, drug formulation, drug deposition, inhalation, particle engineering, COMPUTATIONAL FLUID-DYNAMICS, AIR CLASSIFIER TECHNOLOGY, PULMONARY DRUG-DELIVERY, METERED-DOSE INHALER, SPRAY-DRIED POWDERS, EXCIPIENT ENHANCED GROWTH, LUNG DEPOSITION, AEROSOL DEPOSITION, GAMMA-SCINTIGRAPHY, PARTICLE-SIZE

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