Publication

DRUG DELIVERY BY ORGAN-SPECIFIC IMMUNOLIPOSOMES

MARUYAMA, K., MORI, A., KENNEL, SJ., WAALKES, MVB., SCHERPHOF, GL. & HUANG, L., 1991, In : Acs symposium series. 469, p. 275-284 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • K MARUYAMA
  • A MORI
  • SJ KENNEL
  • MVB WAALKES
  • GL SCHERPHOF
  • L HUANG

Monoclonal antibodies highly specific to the mouse pulmonary endothelial cells were conjugated to liposomes. The resulting immunoliposomes showed high levels of lung accumulation when injected intravenously into mice. Optimal target binding and retention were achieved if the lipid composition included ganglioside (GM1) to reduce the uptake of immunoliposomes by the reticuloendothelial system. Details of the construction and optimization of these organ-specific immunoliposomes are reviewed. The drug delivery potential of this novel liposome system was demonstrated in an experimental pulmonary metastasis model. Immunoliposomes containing a lipophilic prodrug of deoxyfluorouridine effectively prolonged the survival time of the tumor-bearing mice. This and other therapeutic applications of the immunoliposomes are discussed.

Original languageEnglish
Pages (from-to)275-284
Number of pages10
JournalAcs symposium series
Volume469
Publication statusPublished - 1991

    Keywords

  • LIPOSOMES, CIRCULATION, THERAPY, INVIVO, AGENTS, TUMORS, MODELS, LIVER, MICE

ID: 6294916