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Double-brush Langmuir-Blodgett monolayers of alpha-helical diblock copolypeptides

Nguyen, L-T. T., Vorenkamp, E. J., Daumont, C. J. M., ten Brinke, G., Schouten, A. J., Vukovic, I. & Loos, K., 2-Mar-2010, In : Polymer. 51, 5, p. 1042-1055 14 p.

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DOI

  • Le-Thu T. Nguyen
  • Eltjo J. Vorenkamp
  • Christophe J. M. Daumont
  • Gerrit ten Brinke
  • Arend J. Schouten
  • Ivana Vukovic
  • Katja Loos

The synthesis of amphiphilic diblock copolypeptides consisting of poly(alpha-L-glutamic acid) (PLGA) and poly(gamma-methyl-L-glutamate-ran-gamma-stearyl-L-glutamate) with 30 mol % of stearyl substituents (PMLGSLG) and their monolayer behavior at the air-water interface have been studied. PLGA-b-PMLGSLG was synthesized via a diblock copolymer precursor consisting of poly(gamma-tert-butyl-L-glutamate) (PtBuLG) and PMLGSLG blocks, with the tert-butyl group as a mild acid-labile protecting group for the carboxylic acid. The polymerization conditions were found to influence the alpha-helix to beta-sheet content ratio and can be tuned to significantly enhance the cliblock copolypeptide helicity. Purely alpha-helical PtBuLG-b-PMLGSLG diblock copolymers were successfully prepared. After removal of the tert-butyl group, the study of the PLGA-b-PMLGSLG amphiphilic cliblock copolymers in Langmuir monolayers; and Langmuir-Blodgett films demonstrated the formation of a stable alpha-helical double-brush structure, with the helices tilted away from the substrate surface. These double-brush monolayers combine the unique properties arising from the unidirectionally aligned helix macrodipole and the liquid-like features of the side chain mantle of the PMLGSLG block. Such systems are promising for thin film applications requiring incorporation and orientation of bio- and optical molecules. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1042-1055
Number of pages14
JournalPolymer
Volume51
Issue number5
Publication statusPublished - 2-Mar-2010

    Keywords

  • alpha-Helical amphiphilic diblock copolypeptide, Double-brush, Langmuir-Blodgett monolayers, AIR-WATER-INTERFACE, X-RAY REFLECTOMETRY, BENZYL-L-GLUTAMATES, HAIRY-ROD POLYMERS, MOLECULAR-ORIENTATION, SECONDARY STRUCTURE, THIN-FILMS, SYNTHETIC POLYPEPTIDES, CONFORMATIONAL ASPECTS, POLY(L-GLUTAMIC ACID)

ID: 5040350