Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 DiabeticsNesse, W., Linde, A., Abbas, F., Spijkervet, F. K. L., Dijkstra, P. U., de Brabander, E. C., Gerstenbluth, I. & Vissink, A., Apr-2009, In : Journal of Clinical Periodontology. 36, 4, p. 295-300 6 p.
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Nesse W, Linde A, Abbas F, Spijkervet FKL, Dijkstra PU, de Brabander EC, Gerstenbluth I, Vissink A. Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 diabetics. J Clin Periodontol 2009; 36: 295-300. doi: 10.1111/j.1600-051X.2009.01377.x.
A dose-response relationship between the amount of inflamed periodontal tissue and HbA1c level, might be indicative for a causal association between periodontitis and type 2 diabetes.
To assess a dose-response relationship between the periodontal inflamed surface area (PISA), as a measure of the amount of inflamed periodontal tissue, and HbA1c levels in type 2 diabetics.
Forty consecutive dentate type 2 diabetics attending their general practitioner for regular check-up, underwent full-mouth probing pocket depth and bleeding on probing assessment. From these data PISA was calculated. HbA1c levels were retrieved from patients' medical files. The dose-response relationship between PISA and HbA1c levels was assessed using multiple linear regression analyses, controlling for factors that might influence PISA or HbA1c levels.
The higher the PISA of type 2 diabetics was, the higher their HbA1c levels were. On a group level, an increase of PISA with 333 mm(2) was associated with a 1.0 percentage point increase of HbA1c, independent of the influence of other factors.
On a group level, there is a dose-response relationship between PISA and HbA1c in type 2 diabetics. This might be an indication of a causal relationship between type 2 diabetes and periodontitis.
|Number of pages||6|
|Journal||Journal of Clinical Periodontology|
|Publication status||Published - Apr-2009|
- glycosylated hemoglobin A, periodontal inflamed surface area (PISA), periodontitis, type 2 diabetes mellitus, TUMOR-NECROSIS-FACTOR, GLYCEMIC CONTROL, INFLAMMATORY MARKERS, GLYCATED HEMOGLOBIN, FACTOR-ALPHA, MELLITUS, DISEASE, RISK, THERAPY, HEALTH