Publication

Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation

Li, Y., Nieuwenhuis, L. M., Werner, M. J. M., Voskuil, M. D., Gacesa, R., Blokzijl, H., Lisman, T., Weersma, R. K., Porte, R. J., Festen, E. A. M. & de Meijer, V. E., 25-Jul-2020, In : JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Li, Y., Nieuwenhuis, L. M., Werner, M. J. M., Voskuil, M. D., Gacesa, R., Blokzijl, H., ... de Meijer, V. E. (2020). Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. https://doi.org/10.1111/jth.14983

Author

Li, Yanni ; Nieuwenhuis, Lianne M ; Werner, Maureen J M ; Voskuil, Michiel D ; Gacesa, Ranko ; Blokzijl, Hans ; Lisman, Ton ; Weersma, Rinse K ; Porte, Robert J ; Festen, Eleonora A M ; de Meijer, Vincent E. / Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation. In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020.

Harvard

Li, Y, Nieuwenhuis, LM, Werner, MJM, Voskuil, MD, Gacesa, R, Blokzijl, H, Lisman, T, Weersma, RK, Porte, RJ, Festen, EAM & de Meijer, VE 2020, 'Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation', JOURNAL OF THROMBOSIS AND HAEMOSTASIS. https://doi.org/10.1111/jth.14983

Standard

Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation. / Li, Yanni; Nieuwenhuis, Lianne M; Werner, Maureen J M; Voskuil, Michiel D; Gacesa, Ranko; Blokzijl, Hans; Lisman, Ton; Weersma, Rinse K; Porte, Robert J; Festen, Eleonora A M; de Meijer, Vincent E.

In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 25.07.2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Li Y, Nieuwenhuis LM, Werner MJM, Voskuil MD, Gacesa R, Blokzijl H et al. Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020 Jul 25. https://doi.org/10.1111/jth.14983


BibTeX

@article{8dd017aabe114b898b7d32db163b797f,
title = "Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation",
abstract = "BACKGROUND: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined.OBJECTIVES: We aimed to identify risk factors for early post-transplantation thrombosis (<90 days) and to determine the impact of early postoperative thrombosis on long-term graft and patient survival.PATIENTS/METHODS: A post-hoc analysis was performed of an observational cohort study including all primary, adult liver transplantations performed between 1993-2018. Donor-, recipient-, and surgery-related characteristics were collected. Competing risk model analyses and multivariable regression analyses were performed to identify risk factors for developing early post-transplant thrombosis and graft failure.RESULTS: From a total of 748 adult liver transplantations, 58 recipients (7.8{\%}) developed a thrombosis after a median of 7 days. Post-transplantation thrombotic events included 25 hepatic artery thrombosis, 13 portal vein thrombosis, and 22 other thrombotic complications. Donor history of smoking was independently associated with early postoperative thrombosis (OR 2.42; 95{\%} CI, 1.29-4.52). Development of early post-transplant thrombosis was independently associated with patient mortality (HR 3.61; 95{\%}CI 1.54-8.46) and graft failure (HR 5.80, 95{\%}CI 3.26-10.33), respectively.CONCLUSION: Donor history of smoking conveys a more than two-fold increased risk of thrombosis after liver transplantation, independent of other factors. Post-transplant thrombosis was independently associated with decreased patient and graft survival.",
keywords = "graft survival, hepatic artery thrombosis, liver transplantation, portal vein thrombosis, risk factors, HEPATIC-ARTERY THROMBOSIS, PORTAL-VEIN THROMBOSIS, COMPLICATIONS, MANAGEMENT, CYTOMEGALOVIRUS, EXPERIENCE",
author = "Yanni Li and Nieuwenhuis, {Lianne M} and Werner, {Maureen J M} and Voskuil, {Michiel D} and Ranko Gacesa and Hans Blokzijl and Ton Lisman and Weersma, {Rinse K} and Porte, {Robert J} and Festen, {Eleonora A M} and {de Meijer}, {Vincent E}",
note = "This article is protected by copyright. All rights reserved.",
year = "2020",
month = "7",
day = "25",
doi = "10.1111/jth.14983",
language = "English",
journal = "JOURNAL OF THROMBOSIS AND HAEMOSTASIS",
issn = "1538-7933",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation

AU - Li, Yanni

AU - Nieuwenhuis, Lianne M

AU - Werner, Maureen J M

AU - Voskuil, Michiel D

AU - Gacesa, Ranko

AU - Blokzijl, Hans

AU - Lisman, Ton

AU - Weersma, Rinse K

AU - Porte, Robert J

AU - Festen, Eleonora A M

AU - de Meijer, Vincent E

N1 - This article is protected by copyright. All rights reserved.

PY - 2020/7/25

Y1 - 2020/7/25

N2 - BACKGROUND: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined.OBJECTIVES: We aimed to identify risk factors for early post-transplantation thrombosis (<90 days) and to determine the impact of early postoperative thrombosis on long-term graft and patient survival.PATIENTS/METHODS: A post-hoc analysis was performed of an observational cohort study including all primary, adult liver transplantations performed between 1993-2018. Donor-, recipient-, and surgery-related characteristics were collected. Competing risk model analyses and multivariable regression analyses were performed to identify risk factors for developing early post-transplant thrombosis and graft failure.RESULTS: From a total of 748 adult liver transplantations, 58 recipients (7.8%) developed a thrombosis after a median of 7 days. Post-transplantation thrombotic events included 25 hepatic artery thrombosis, 13 portal vein thrombosis, and 22 other thrombotic complications. Donor history of smoking was independently associated with early postoperative thrombosis (OR 2.42; 95% CI, 1.29-4.52). Development of early post-transplant thrombosis was independently associated with patient mortality (HR 3.61; 95%CI 1.54-8.46) and graft failure (HR 5.80, 95%CI 3.26-10.33), respectively.CONCLUSION: Donor history of smoking conveys a more than two-fold increased risk of thrombosis after liver transplantation, independent of other factors. Post-transplant thrombosis was independently associated with decreased patient and graft survival.

AB - BACKGROUND: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined.OBJECTIVES: We aimed to identify risk factors for early post-transplantation thrombosis (<90 days) and to determine the impact of early postoperative thrombosis on long-term graft and patient survival.PATIENTS/METHODS: A post-hoc analysis was performed of an observational cohort study including all primary, adult liver transplantations performed between 1993-2018. Donor-, recipient-, and surgery-related characteristics were collected. Competing risk model analyses and multivariable regression analyses were performed to identify risk factors for developing early post-transplant thrombosis and graft failure.RESULTS: From a total of 748 adult liver transplantations, 58 recipients (7.8%) developed a thrombosis after a median of 7 days. Post-transplantation thrombotic events included 25 hepatic artery thrombosis, 13 portal vein thrombosis, and 22 other thrombotic complications. Donor history of smoking was independently associated with early postoperative thrombosis (OR 2.42; 95% CI, 1.29-4.52). Development of early post-transplant thrombosis was independently associated with patient mortality (HR 3.61; 95%CI 1.54-8.46) and graft failure (HR 5.80, 95%CI 3.26-10.33), respectively.CONCLUSION: Donor history of smoking conveys a more than two-fold increased risk of thrombosis after liver transplantation, independent of other factors. Post-transplant thrombosis was independently associated with decreased patient and graft survival.

KW - graft survival

KW - hepatic artery thrombosis

KW - liver transplantation

KW - portal vein thrombosis

KW - risk factors

KW - HEPATIC-ARTERY THROMBOSIS

KW - PORTAL-VEIN THROMBOSIS

KW - COMPLICATIONS

KW - MANAGEMENT

KW - CYTOMEGALOVIRUS

KW - EXPERIENCE

U2 - 10.1111/jth.14983

DO - 10.1111/jth.14983

M3 - Article

C2 - 32614986

JO - JOURNAL OF THROMBOSIS AND HAEMOSTASIS

JF - JOURNAL OF THROMBOSIS AND HAEMOSTASIS

SN - 1538-7933

ER -

ID: 129095170