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Donor tobacco smoking is associated with postoperative thrombosis after primary liver transplantation

Li, Y., Nieuwenhuis, L. M., Werner, M. J. M., Voskuil, M. D., Gacesa, R., Blokzijl, H., Lisman, T., Weersma, R. K., Porte, R. J., Festen, E. A. M. & de Meijer, V. E., 25-Jul-2020, In : JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

BACKGROUND: Thrombosis after liver transplantation is a leading cause of graft loss, morbidity, and mortality. Several known recipient- and surgery-related characteristics have been associated with increased risk of thrombosis after transplantation. Potential donor-related risk factors, however, remain largely undefined.

OBJECTIVES: We aimed to identify risk factors for early post-transplantation thrombosis (<90 days) and to determine the impact of early postoperative thrombosis on long-term graft and patient survival.

PATIENTS/METHODS: A post-hoc analysis was performed of an observational cohort study including all primary, adult liver transplantations performed between 1993-2018. Donor-, recipient-, and surgery-related characteristics were collected. Competing risk model analyses and multivariable regression analyses were performed to identify risk factors for developing early post-transplant thrombosis and graft failure.

RESULTS: From a total of 748 adult liver transplantations, 58 recipients (7.8%) developed a thrombosis after a median of 7 days. Post-transplantation thrombotic events included 25 hepatic artery thrombosis, 13 portal vein thrombosis, and 22 other thrombotic complications. Donor history of smoking was independently associated with early postoperative thrombosis (OR 2.42; 95% CI, 1.29-4.52). Development of early post-transplant thrombosis was independently associated with patient mortality (HR 3.61; 95%CI 1.54-8.46) and graft failure (HR 5.80, 95%CI 3.26-10.33), respectively.

CONCLUSION: Donor history of smoking conveys a more than two-fold increased risk of thrombosis after liver transplantation, independent of other factors. Post-transplant thrombosis was independently associated with decreased patient and graft survival.

Original languageEnglish
Number of pages11
JournalJOURNAL OF THROMBOSIS AND HAEMOSTASIS
Early online date2-Jul-2020
Publication statusPublished - 25-Jul-2020

    Keywords

  • graft survival, hepatic artery thrombosis, liver transplantation, portal vein thrombosis, risk factors, HEPATIC-ARTERY THROMBOSIS, PORTAL-VEIN THROMBOSIS, COMPLICATIONS, MANAGEMENT, CYTOMEGALOVIRUS, EXPERIENCE

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