Does smoking influence outcome after intravenous thrombolysis for acute ischaemic stroke?

Aries, M. J. H., Uyttenboogaart, M., Koch, M. W., Langedijk, M., Vroomen, P. C., Luijckx, G. J. & De Keyser, J., Jul-2009, In : European Journal of Neurology. 16, 7, p. 819-822 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

It remains uncertain whether current smoking influences outcome in patients with acute ischaemic stroke.

To evaluate the effect of current smoking in routinely tissue plasminogen activator (tPA)-treated stroke patients on the 3-month functional outcome and the occurrence of symptomatic intracerebral hemorrhage (ICH).

We analyzed data from a single stroke care unit registry of 345 consecutive patients with ischaemic stroke, treated with tPA. Logistic regression models were used to assess if smoking was independently associated with 3-months good outcome defined as a modified Rankin Scale score of

In the multivariable models, smoking was not associated with a good outcome or a decreased risk of symptomatic ICH.

Current smoking did not affect functional outcome at 3 months or the risk of symptomatic ICH in patients routinely treated with tPA for ischaemic stroke.

Original languageEnglish
Pages (from-to)819-822
Number of pages4
JournalEuropean Journal of Neurology
Issue number7
Publication statusPublished - Jul-2009


  • ischaemic stroke, outcome, smoking, symptomatic intracerebral hemorrhage, thrombolysis, tissue plasminogen activator, ACUTE MYOCARDIAL-INFARCTION, THERAPY, TRIAL, MORTALITY, PARADOX

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