Publication

Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

van der Meulen, M. H., den Boer, S., Sarvaas, G. J. D. M., Blom, N. A., Ten Harkel, A. D. J., Breur, H. M. P. J., Rammeloo, L. A. J., Tanke, R., Helbing, W. A., Boersma, E. & Dalinghaus, M., 12-Nov-2019, In : Pediatric cardiology. 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van der Meulen, M. H., den Boer, S., Sarvaas, G. J. D. M., Blom, N. A., Ten Harkel, A. D. J., Breur, H. M. P. J., ... Dalinghaus, M. (2019). Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy? Pediatric cardiology. https://doi.org/10.1007/s00246-019-02244-7

Author

van der Meulen, Marijke H. ; den Boer, Susanna ; Sarvaas, Gideon J. du Marchie ; Blom, Nico A. ; Ten Harkel, Arend D. J. ; Breur, Hans M. P. J. ; Rammeloo, Lukas A. J. ; Tanke, Ronald ; Helbing, Willem A. ; Boersma, Eric ; Dalinghaus, Michiel. / Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?. In: Pediatric cardiology. 2019.

Harvard

van der Meulen, MH, den Boer, S, Sarvaas, GJDM, Blom, NA, Ten Harkel, ADJ, Breur, HMPJ, Rammeloo, LAJ, Tanke, R, Helbing, WA, Boersma, E & Dalinghaus, M 2019, 'Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?', Pediatric cardiology. https://doi.org/10.1007/s00246-019-02244-7

Standard

Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy? / van der Meulen, Marijke H.; den Boer, Susanna; Sarvaas, Gideon J. du Marchie; Blom, Nico A.; Ten Harkel, Arend D. J.; Breur, Hans M. P. J.; Rammeloo, Lukas A. J.; Tanke, Ronald; Helbing, Willem A.; Boersma, Eric; Dalinghaus, Michiel.

In: Pediatric cardiology, 12.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van der Meulen MH, den Boer S, Sarvaas GJDM, Blom NA, Ten Harkel ADJ, Breur HMPJ et al. Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy? Pediatric cardiology. 2019 Nov 12. https://doi.org/10.1007/s00246-019-02244-7


BibTeX

@article{3eee3b6c6f1849388445c6ff74987de5,
title = "Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?",
abstract = "A single 6-min walk test (6MWT) can be used to identify children with dilated cardiomyopathy (DCM) with a high risk of death or heart transplantation. To determine if repeated 6MWT has added value in addition to a single 6MWT in predicting death or heart transplantation in children with DCM. Prospective multicenter cohort study including ambulatory DCM patients >= 6 years. A 6MWT was performed 1 to 4 times per year. The distance walked was expressed as percentage of predicted (6MWD{\%}). We compared the temporal evolution of 6MWD{\%} in patients with and without the study endpoint (SE: all-cause death or heart transplantation), using a linear mixed effects model. In 57 patients, we obtained a median of 4 (IQR 2-6) 6MWTs per patient during a median of 3.0 years of observation (IQR 1.5-5.1). Fourteen patients reached a SE (3 deaths, 11 heart transplantations). At any time during follow-up, the average estimate of 6MWD{\%} was significantly lower in patients with a SE compared to patients without a SE. In both patients groups, 6MWD{\%} remained constant over time. An absolute 1{\%} lower 6MWD{\%} was associated with an 11{\%} higher risk (hazard) of the SE (HR 0.90, 95{\%} CI 0.86-0.95 p <0.001). Children with DCM who died or underwent heart transplantation had systematically reduced 6MWD{\%}. The performance of all patients was stable over time, so repeated measurement of 6MWT within this time frame had little added value over a single test.",
keywords = "Dilated cardiomyopathy, Heart failure, Pediatric cardiology, Risk factors, 6MWT, CHRONIC HEART-FAILURE, TRANSPLANTATION, MANAGEMENT, DISTANCE",
author = "{van der Meulen}, {Marijke H.} and {den Boer}, Susanna and Sarvaas, {Gideon J. du Marchie} and Blom, {Nico A.} and {Ten Harkel}, {Arend D. J.} and Breur, {Hans M. P. J.} and Rammeloo, {Lukas A. J.} and Ronald Tanke and Helbing, {Willem A.} and Eric Boersma and Michiel Dalinghaus",
year = "2019",
month = "11",
day = "12",
doi = "10.1007/s00246-019-02244-7",
language = "English",
journal = "Pediatric cardiology",
issn = "0172-0643",
publisher = "SPRINGER",

}

RIS

TY - JOUR

T1 - Does Repeated Measurement of a 6-Min Walk Test Contribute to Risk Prediction in Children with Dilated Cardiomyopathy?

AU - van der Meulen, Marijke H.

AU - den Boer, Susanna

AU - Sarvaas, Gideon J. du Marchie

AU - Blom, Nico A.

AU - Ten Harkel, Arend D. J.

AU - Breur, Hans M. P. J.

AU - Rammeloo, Lukas A. J.

AU - Tanke, Ronald

AU - Helbing, Willem A.

AU - Boersma, Eric

AU - Dalinghaus, Michiel

PY - 2019/11/12

Y1 - 2019/11/12

N2 - A single 6-min walk test (6MWT) can be used to identify children with dilated cardiomyopathy (DCM) with a high risk of death or heart transplantation. To determine if repeated 6MWT has added value in addition to a single 6MWT in predicting death or heart transplantation in children with DCM. Prospective multicenter cohort study including ambulatory DCM patients >= 6 years. A 6MWT was performed 1 to 4 times per year. The distance walked was expressed as percentage of predicted (6MWD%). We compared the temporal evolution of 6MWD% in patients with and without the study endpoint (SE: all-cause death or heart transplantation), using a linear mixed effects model. In 57 patients, we obtained a median of 4 (IQR 2-6) 6MWTs per patient during a median of 3.0 years of observation (IQR 1.5-5.1). Fourteen patients reached a SE (3 deaths, 11 heart transplantations). At any time during follow-up, the average estimate of 6MWD% was significantly lower in patients with a SE compared to patients without a SE. In both patients groups, 6MWD% remained constant over time. An absolute 1% lower 6MWD% was associated with an 11% higher risk (hazard) of the SE (HR 0.90, 95% CI 0.86-0.95 p <0.001). Children with DCM who died or underwent heart transplantation had systematically reduced 6MWD%. The performance of all patients was stable over time, so repeated measurement of 6MWT within this time frame had little added value over a single test.

AB - A single 6-min walk test (6MWT) can be used to identify children with dilated cardiomyopathy (DCM) with a high risk of death or heart transplantation. To determine if repeated 6MWT has added value in addition to a single 6MWT in predicting death or heart transplantation in children with DCM. Prospective multicenter cohort study including ambulatory DCM patients >= 6 years. A 6MWT was performed 1 to 4 times per year. The distance walked was expressed as percentage of predicted (6MWD%). We compared the temporal evolution of 6MWD% in patients with and without the study endpoint (SE: all-cause death or heart transplantation), using a linear mixed effects model. In 57 patients, we obtained a median of 4 (IQR 2-6) 6MWTs per patient during a median of 3.0 years of observation (IQR 1.5-5.1). Fourteen patients reached a SE (3 deaths, 11 heart transplantations). At any time during follow-up, the average estimate of 6MWD% was significantly lower in patients with a SE compared to patients without a SE. In both patients groups, 6MWD% remained constant over time. An absolute 1% lower 6MWD% was associated with an 11% higher risk (hazard) of the SE (HR 0.90, 95% CI 0.86-0.95 p <0.001). Children with DCM who died or underwent heart transplantation had systematically reduced 6MWD%. The performance of all patients was stable over time, so repeated measurement of 6MWT within this time frame had little added value over a single test.

KW - Dilated cardiomyopathy

KW - Heart failure

KW - Pediatric cardiology

KW - Risk factors

KW - 6MWT

KW - CHRONIC HEART-FAILURE

KW - TRANSPLANTATION

KW - MANAGEMENT

KW - DISTANCE

U2 - 10.1007/s00246-019-02244-7

DO - 10.1007/s00246-019-02244-7

M3 - Article

JO - Pediatric cardiology

JF - Pediatric cardiology

SN - 0172-0643

ER -

ID: 107589468