Does deep brain stimulation improve lower urinary tract symptoms in Parkinson's disease?

Witte, L. P., Odekerken, V. J. J., Boel, J. A., Gerbrandy-Schreuders, L. C., Schuurman, P. R., de Bie, R. M. A. & NSTAPS study group, Jan-2018, In : Neurourology and urodynamics. 37, 1, p. 354-359 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard


  • Witte_et_al-2018-Neurourology_and_Urodynamics

    Final publisher's version, 245 KB, PDF document


  • Lambertus P Witte
  • Vincent J J Odekerken
  • Judith A Boel
  • Lara C Gerbrandy-Schreuders
  • P Richard Schuurman
  • Rob M A de Bie
  • NSTAPS study group

AIMS: To investigate whether deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) or the subthalamic nucleus (STN) improve lower urinary tract symptoms (LUTS) in advanced Parkinson's disease (PD).

METHODS: An exploratory post-hoc analysis was performed of specific LUTS items of questionnaires used in a randomized clinical trial with 128 patients (NSTAPS study). First, we compared scores on LUTS items at baseline and 12 months for the GPi DBS and STN DBS group separately. Second, we divided the group by sex, instead of DBS location; to assess a possible gender associated influence of anatomical and pathophysiological differences, again comparing scores at baseline and 12 months. Third, we reported on Foley-catheter use at baseline and after 12 months.

RESULTS: Urinary incontinence and frequency improved after both GPi DBS and STN DBS at 12 months, postoperatively, but this was only statistically significant for the STN DBS group (P = 0.004). The improvements after DBS were present in both men (P = 0.01) and women (P = 0.05). Nocturia and urinary incontinence did not improve significantly after any type of DBS, irrespective of sex. At 12 months, none of the patients had a Foley-catheter.

CONCLUSIONS: Urinary incontinence and frequency significantly improved after STN DBS treatment in male and female patients with PD. Nocturia and nighttime incontinence due to parkinsonism did not improve after DBS, irrespective of gender.

Original languageEnglish
Pages (from-to)354-359
Number of pages6
JournalNeurourology and urodynamics
Issue number1
Publication statusPublished - Jan-2018

View graph of relations

ID: 81367279