Do recommended high-risk adults benefit from a first influenza vaccination?

Hak, E., Buskens, E., Nichol, K. L. & Verheij, T. J. M., 5-Apr-2006, In : Vaccine. 24, 15, p. 2799-2802 4 p.

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It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic. (c) 2006 Elsevier Ltd. All rights reserved
Original languageEnglish
Pages (from-to)2799-2802
Number of pages4
Issue number15
Publication statusPublished - 5-Apr-2006


  • Adult, Case-Control Studies, Cohort Studies, Disease Outbreaks, Female, Hospitalization, Humans, Influenza Vaccines, Influenza, Human, Male, Middle Aged, Respiratory Tract Infections, Risk Factors

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