DNA Self-Assembly Mediated by Programmable Soft-Patchy InteractionsNovak, S., Zhang, J., Kentzinger, E., Rücker, U., Portale, G., Jung, N., Jonas, U., Myung, J. S., Winkler, R. G., Gompper, G., Dhont, J. K. G. & Stiakakis, E., 27-Oct-2020, In : Acs Nano. 14, 10, p. 13524–13535
Research output: Contribution to journal › Article › Academic › peer-review
Adding shape and interaction anisotropy to a colloidal particle offers exquisitely tunable routes to engineer a rich assortment of complex-architected structures. Inspired by the hierarchical self-assembly concept with block copolymers and DNA liquid crystals and exploiting the unique assembly properties of DNA, we report here the construction and self-assembly of DNA-based soft-patchy anisotropic particles with a high degree of modularity in the system's design. By programmable positioning of thermoresponsive polymeric patches on the backbone of a stiff DNA duplex with linear and star-shaped architecture, we reversibly drive the DNA from a disordered ensemble to a diverse array of long-range ordered multidimensional nanostructures with tunable lattice spacing, ranging from lamellar to bicontinuous double-gyroid and double-diamond cubic morphologies, through the alteration of temperature. Our results demonstrate that the proposed hierarchical self-assembly strategy can be applied to any kind of DNA nanoarchitecture, highlighting the design principles for integration of self-assembly concepts from the physics of liquid crystals, block copolymers, and patchy colloids into the continuously growing interdisciplinary research field of structural DNA nanotechnology.
|Early online date||2020|
|Publication status||Published - 27-Oct-2020|