Publication

Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review

Nijenhuis, C. M., Ter Horst, P. G., de Jong-van den Berg, L. T. & Wilffert, B., Jan-2012, In : British Journal of Clinical Pharmacology. 73, 1, p. 16-26 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Nijenhuis, C. M., Ter Horst, P. G., de Jong-van den Berg, L. T., & Wilffert, B. (2012). Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review. British Journal of Clinical Pharmacology, 73(1), 16-26. https://doi.org/10.1111/j.1365-2125.2011.04075.x

Author

Nijenhuis, C.M. ; Ter Horst, P.G. ; de Jong-van den Berg, L.T. ; Wilffert, B. / Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1 : Literature review. In: British Journal of Clinical Pharmacology. 2012 ; Vol. 73, No. 1. pp. 16-26.

Harvard

Nijenhuis, CM, Ter Horst, PG, de Jong-van den Berg, LT & Wilffert, B 2012, 'Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review' British Journal of Clinical Pharmacology, vol. 73, no. 1, pp. 16-26. https://doi.org/10.1111/j.1365-2125.2011.04075.x

Standard

Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1 : Literature review. / Nijenhuis, C.M.; Ter Horst, P.G.; de Jong-van den Berg, L.T.; Wilffert, B.

In: British Journal of Clinical Pharmacology, Vol. 73, No. 1, 01.2012, p. 16-26.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Nijenhuis CM, Ter Horst PG, de Jong-van den Berg LT, Wilffert B. Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review. British Journal of Clinical Pharmacology. 2012 Jan;73(1):16-26. https://doi.org/10.1111/j.1365-2125.2011.04075.x


BibTeX

@article{8686baeaa1fd41588cd7bd80eb3aa94e,
title = "Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review",
abstract = "The increase in selective serotonin re-uptake inhibitor (SSRI) use during pregnancy, questions concerning abnormal development of the enteric nervous system (ENS), increase in laxative use in children and the association of fluoxetine with infantile hypertrophic pyloric stenosis (IHPS) gave rise to this pharmacological literature review. The role of 5-HT and the NE uptake in ontogeny of the ENS and the effects SSRIs and TCAs might have on the development of the ENS were investigated. The literature study showed that SSRIs may influence the development of the ENS in two ways. Blockage of the serotonin re-uptake transporter (SERT) during foetal development could influence migration, differentiation and survival of cells. This could lead to abnormal development in the first trimester of pregnancy. The other way is that 5-HT seems to be a growth factor in the primitive ENS. This growth factor like action is mediated through the 5-HT2B receptor and stimulation of this receptor by SSRIs influences the fate of late-developing enteric neurons. This could lead to abnormal development in the second and third trimester. TCAs could influence the development of the ENS, besides through inhibition of the SERT, through inhibition of the norepinephrine transporter (NET). Expression of the NET seems to be essential for a full development of enteric neurons and especially for serotonergic neurons. In addition the NET was detected early in ontogeny and precedes neuronal differentiation, which suggests that TCAs might influence development of the ENS when exposed early in pregnancy. The insights of this study gave rise to hypotheses which will be tested in an epidemiological cohort study.",
keywords = "enteric nervous system, norepinephrine transporter, ontogeny, selective serotonin re-uptake inhibitor, serotonin re-uptake transporter, tricyclic antidepressants, POPULATION-BASED COHORT, CONGENITAL-MALFORMATIONS, INTERSTITIAL-CELLS, 5-HT2B RECEPTOR, NOREPINEPHRINE TRANSPORTER, GASTROINTESTINAL-TRACT, EARLY-PREGNANCY, BIRTH-DEFECTS, MATERNAL USE, PLACENTAL PASSAGE",
author = "C.M. Nijenhuis and {Ter Horst}, P.G. and {de Jong-van den Berg}, L.T. and B. Wilffert",
year = "2012",
month = "1",
doi = "10.1111/j.1365-2125.2011.04075.x",
language = "English",
volume = "73",
pages = "16--26",
journal = "British Journal of Clinical Pharmacology",
issn = "0306-5251",
publisher = "WILEY",
number = "1",

}

RIS

TY - JOUR

T1 - Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1

T2 - Literature review

AU - Nijenhuis, C.M.

AU - Ter Horst, P.G.

AU - de Jong-van den Berg, L.T.

AU - Wilffert, B.

PY - 2012/1

Y1 - 2012/1

N2 - The increase in selective serotonin re-uptake inhibitor (SSRI) use during pregnancy, questions concerning abnormal development of the enteric nervous system (ENS), increase in laxative use in children and the association of fluoxetine with infantile hypertrophic pyloric stenosis (IHPS) gave rise to this pharmacological literature review. The role of 5-HT and the NE uptake in ontogeny of the ENS and the effects SSRIs and TCAs might have on the development of the ENS were investigated. The literature study showed that SSRIs may influence the development of the ENS in two ways. Blockage of the serotonin re-uptake transporter (SERT) during foetal development could influence migration, differentiation and survival of cells. This could lead to abnormal development in the first trimester of pregnancy. The other way is that 5-HT seems to be a growth factor in the primitive ENS. This growth factor like action is mediated through the 5-HT2B receptor and stimulation of this receptor by SSRIs influences the fate of late-developing enteric neurons. This could lead to abnormal development in the second and third trimester. TCAs could influence the development of the ENS, besides through inhibition of the SERT, through inhibition of the norepinephrine transporter (NET). Expression of the NET seems to be essential for a full development of enteric neurons and especially for serotonergic neurons. In addition the NET was detected early in ontogeny and precedes neuronal differentiation, which suggests that TCAs might influence development of the ENS when exposed early in pregnancy. The insights of this study gave rise to hypotheses which will be tested in an epidemiological cohort study.

AB - The increase in selective serotonin re-uptake inhibitor (SSRI) use during pregnancy, questions concerning abnormal development of the enteric nervous system (ENS), increase in laxative use in children and the association of fluoxetine with infantile hypertrophic pyloric stenosis (IHPS) gave rise to this pharmacological literature review. The role of 5-HT and the NE uptake in ontogeny of the ENS and the effects SSRIs and TCAs might have on the development of the ENS were investigated. The literature study showed that SSRIs may influence the development of the ENS in two ways. Blockage of the serotonin re-uptake transporter (SERT) during foetal development could influence migration, differentiation and survival of cells. This could lead to abnormal development in the first trimester of pregnancy. The other way is that 5-HT seems to be a growth factor in the primitive ENS. This growth factor like action is mediated through the 5-HT2B receptor and stimulation of this receptor by SSRIs influences the fate of late-developing enteric neurons. This could lead to abnormal development in the second and third trimester. TCAs could influence the development of the ENS, besides through inhibition of the SERT, through inhibition of the norepinephrine transporter (NET). Expression of the NET seems to be essential for a full development of enteric neurons and especially for serotonergic neurons. In addition the NET was detected early in ontogeny and precedes neuronal differentiation, which suggests that TCAs might influence development of the ENS when exposed early in pregnancy. The insights of this study gave rise to hypotheses which will be tested in an epidemiological cohort study.

KW - enteric nervous system

KW - norepinephrine transporter

KW - ontogeny

KW - selective serotonin re-uptake inhibitor

KW - serotonin re-uptake transporter

KW - tricyclic antidepressants

KW - POPULATION-BASED COHORT

KW - CONGENITAL-MALFORMATIONS

KW - INTERSTITIAL-CELLS

KW - 5-HT2B RECEPTOR

KW - NOREPINEPHRINE TRANSPORTER

KW - GASTROINTESTINAL-TRACT

KW - EARLY-PREGNANCY

KW - BIRTH-DEFECTS

KW - MATERNAL USE

KW - PLACENTAL PASSAGE

U2 - 10.1111/j.1365-2125.2011.04075.x

DO - 10.1111/j.1365-2125.2011.04075.x

M3 - Review article

VL - 73

SP - 16

EP - 26

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

SN - 0306-5251

IS - 1

ER -

ID: 2462619