Publication

Distinct Cognitive Trajectories in the First Year After Hip Fracture

Beishuizen, S. J. E., van Munster, B. C., de Jonghe, A., Abu-Hanna, A., Buurman, B. M. & de Rooij, S. E., May-2017, In : Journal of the American Geriatrics Society. 65, 5, p. 1034-1042 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Beishuizen, S. J. E., van Munster, B. C., de Jonghe, A., Abu-Hanna, A., Buurman, B. M., & de Rooij, S. E. (2017). Distinct Cognitive Trajectories in the First Year After Hip Fracture. Journal of the American Geriatrics Society, 65(5), 1034-1042. https://doi.org/10.1111/jgs.14754

Author

Beishuizen, Sara J. E. ; van Munster, Barbara C. ; de Jonghe, Annemarieke ; Abu-Hanna, Ameen ; Buurman, Bianca M. ; de Rooij, Sophia E. / Distinct Cognitive Trajectories in the First Year After Hip Fracture. In: Journal of the American Geriatrics Society. 2017 ; Vol. 65, No. 5. pp. 1034-1042.

Harvard

Beishuizen, SJE, van Munster, BC, de Jonghe, A, Abu-Hanna, A, Buurman, BM & de Rooij, SE 2017, 'Distinct Cognitive Trajectories in the First Year After Hip Fracture', Journal of the American Geriatrics Society, vol. 65, no. 5, pp. 1034-1042. https://doi.org/10.1111/jgs.14754

Standard

Distinct Cognitive Trajectories in the First Year After Hip Fracture. / Beishuizen, Sara J. E.; van Munster, Barbara C.; de Jonghe, Annemarieke; Abu-Hanna, Ameen; Buurman, Bianca M.; de Rooij, Sophia E.

In: Journal of the American Geriatrics Society, Vol. 65, No. 5, 05.2017, p. 1034-1042.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Beishuizen SJE, van Munster BC, de Jonghe A, Abu-Hanna A, Buurman BM, de Rooij SE. Distinct Cognitive Trajectories in the First Year After Hip Fracture. Journal of the American Geriatrics Society. 2017 May;65(5):1034-1042. https://doi.org/10.1111/jgs.14754


BibTeX

@article{b8ae6cefe60d4335ac300646bd3869cc,
title = "Distinct Cognitive Trajectories in the First Year After Hip Fracture",
abstract = "ObjectivesChange in cognitive functioning is often observed after hip fracture. Different patterns, with both improvement and decline, are expected, depending on premorbid cognitive functioning and events that occur during hospitalization. These patterns are unknown and important for older hip fracture patients with different levels of premorbid cognitive functioning.Design, Setting, Participants, MeasurementsWe conducted a secondary analysis of a multi-center randomized controlled trial. 302 consecutive patients aged 65-102 years old, admitted for hip fracture surgery, were enrolled. The Mini Mental State Examination (MMSE) was obtained at hospital admission, at discharge, and at 3 and 12 months after discharge. Cognitive trajectories were identified with Group Based Trajectory Modelling, using the repeated MMSE measurements as outcome variable. To illustrate the specific characteristics of this relative novel methodological approach, it was contrasted with results obtained from linear mixed effects modeling.Results146 (48.3%) patients had premorbid cognitive impairment and 85 patients (28.1%) experienced delirium during admission. Three distinct cognitive trajectories were identified and labeled based on different MMSE course over time: improvement (57.9%), stable (28.1%), and rapid decline (13.9%), with an annual MMSE change of 1.7, 0.8, and -3.5 points respectively. With mixed effects modeling an overall annual increase of 0.7 MMSE points was estimated for the group as a whole.ConclusionThree distinct cognitive trajectories were identified in a population of older hip fracture patients. These trajectory groups can be used as a starting point to inform patients and caregivers on the possible prognosis after hip fracture. Group based trajectory modelling is a useful technique when the purpose is to describe patterns of change within a population and a variety of trajectories are expected to exist.",
keywords = "cognitive trajectories, hip fracture, delirium, OLDER PERSONS, POSTOPERATIVE DELIRIUM, FUNCTIONAL STATUS, ELDERLY-PATIENTS, CRITICAL ILLNESS, DEMENTIA, DECLINE, DISEASE, HOSPITALIZATION, ASSOCIATION",
author = "Beishuizen, {Sara J. E.} and {van Munster}, {Barbara C.} and {de Jonghe}, Annemarieke and Ameen Abu-Hanna and Buurman, {Bianca M.} and {de Rooij}, {Sophia E.}",
note = "{\textcopyright} 2017, Copyright the Authors Journal compilation {\textcopyright} 2017, The American Geriatrics Society.",
year = "2017",
month = may,
doi = "10.1111/jgs.14754",
language = "English",
volume = "65",
pages = "1034--1042",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Distinct Cognitive Trajectories in the First Year After Hip Fracture

AU - Beishuizen, Sara J. E.

AU - van Munster, Barbara C.

AU - de Jonghe, Annemarieke

AU - Abu-Hanna, Ameen

AU - Buurman, Bianca M.

AU - de Rooij, Sophia E.

N1 - © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

PY - 2017/5

Y1 - 2017/5

N2 - ObjectivesChange in cognitive functioning is often observed after hip fracture. Different patterns, with both improvement and decline, are expected, depending on premorbid cognitive functioning and events that occur during hospitalization. These patterns are unknown and important for older hip fracture patients with different levels of premorbid cognitive functioning.Design, Setting, Participants, MeasurementsWe conducted a secondary analysis of a multi-center randomized controlled trial. 302 consecutive patients aged 65-102 years old, admitted for hip fracture surgery, were enrolled. The Mini Mental State Examination (MMSE) was obtained at hospital admission, at discharge, and at 3 and 12 months after discharge. Cognitive trajectories were identified with Group Based Trajectory Modelling, using the repeated MMSE measurements as outcome variable. To illustrate the specific characteristics of this relative novel methodological approach, it was contrasted with results obtained from linear mixed effects modeling.Results146 (48.3%) patients had premorbid cognitive impairment and 85 patients (28.1%) experienced delirium during admission. Three distinct cognitive trajectories were identified and labeled based on different MMSE course over time: improvement (57.9%), stable (28.1%), and rapid decline (13.9%), with an annual MMSE change of 1.7, 0.8, and -3.5 points respectively. With mixed effects modeling an overall annual increase of 0.7 MMSE points was estimated for the group as a whole.ConclusionThree distinct cognitive trajectories were identified in a population of older hip fracture patients. These trajectory groups can be used as a starting point to inform patients and caregivers on the possible prognosis after hip fracture. Group based trajectory modelling is a useful technique when the purpose is to describe patterns of change within a population and a variety of trajectories are expected to exist.

AB - ObjectivesChange in cognitive functioning is often observed after hip fracture. Different patterns, with both improvement and decline, are expected, depending on premorbid cognitive functioning and events that occur during hospitalization. These patterns are unknown and important for older hip fracture patients with different levels of premorbid cognitive functioning.Design, Setting, Participants, MeasurementsWe conducted a secondary analysis of a multi-center randomized controlled trial. 302 consecutive patients aged 65-102 years old, admitted for hip fracture surgery, were enrolled. The Mini Mental State Examination (MMSE) was obtained at hospital admission, at discharge, and at 3 and 12 months after discharge. Cognitive trajectories were identified with Group Based Trajectory Modelling, using the repeated MMSE measurements as outcome variable. To illustrate the specific characteristics of this relative novel methodological approach, it was contrasted with results obtained from linear mixed effects modeling.Results146 (48.3%) patients had premorbid cognitive impairment and 85 patients (28.1%) experienced delirium during admission. Three distinct cognitive trajectories were identified and labeled based on different MMSE course over time: improvement (57.9%), stable (28.1%), and rapid decline (13.9%), with an annual MMSE change of 1.7, 0.8, and -3.5 points respectively. With mixed effects modeling an overall annual increase of 0.7 MMSE points was estimated for the group as a whole.ConclusionThree distinct cognitive trajectories were identified in a population of older hip fracture patients. These trajectory groups can be used as a starting point to inform patients and caregivers on the possible prognosis after hip fracture. Group based trajectory modelling is a useful technique when the purpose is to describe patterns of change within a population and a variety of trajectories are expected to exist.

KW - cognitive trajectories

KW - hip fracture

KW - delirium

KW - OLDER PERSONS

KW - POSTOPERATIVE DELIRIUM

KW - FUNCTIONAL STATUS

KW - ELDERLY-PATIENTS

KW - CRITICAL ILLNESS

KW - DEMENTIA

KW - DECLINE

KW - DISEASE

KW - HOSPITALIZATION

KW - ASSOCIATION

U2 - 10.1111/jgs.14754

DO - 10.1111/jgs.14754

M3 - Article

C2 - 28152178

VL - 65

SP - 1034

EP - 1042

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 5

ER -

ID: 41824364