Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic featuresKrijgsman, O., Gonzalez, P., Ponz, O. B., Roemer, M. G. M., Slot, S., Broeks, A., Braaf, L., Kerkhoven, R. M., Bot, F., van Groningen, K., Beijert, M., Ylstra, B. & de Jongi, D., Dec-2013, In : Haematologica. 98, 12, p. 1921-1929 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
Nodal marginal zone lymphoma is a poorly defined entity in the World Health Organization classification, based largely on criteria of exclusion and the diagnosis often remains subjective. Follicular lymphoma lacking t(14;18) has similar characteristics which results in a major potential diagnostic overlap which this study aims to dissect. Four subgroups of lymphoma samples (n=56) were analyzed with high-resolution array comparative genome hybridization: nodal marginal zone lymphoma, t(14;18)-negative follicular lymphoma, localized t(14:18)-positive follicular lymphoma and disseminated t(14; 18)-positive follicular lymphoma. Gains on chromosomes 7, 8 and 12 were observed in all subgroups. The mean number of aberrations was higher in disseminated t(14; 18)-positive follicular lymphoma than in localized t(14: 18)-positive follicular lymphoma (P
|Number of pages||9|
|Publication status||Published - Dec-2013|
- COMPARATIVE GENOMIC HYBRIDIZATION, COPY NUMBER, BCL2 GENE, T(14/18), EXPRESSION, TRANSLOCATION, TRANSFORMATION, ABNORMALITIES, ABERRATIONS, MUTATIONS