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Dissecting the gray zone between follicular lymphoma and marginal zone lymphoma using morphological and genetic features

Krijgsman, O., Gonzalez, P., Ponz, O. B., Roemer, M. G. M., Slot, S., Broeks, A., Braaf, L., Kerkhoven, R. M., Bot, F., van Groningen, K., Beijert, M., Ylstra, B. & de Jongi, D., Dec-2013, In : Haematologica. 98, 12, p. 1921-1929 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Oscar Krijgsman
  • Patricia Gonzalez
  • Olga Balague Ponz
  • Margaretha G. M. Roemer
  • Stefanie Slot
  • Annegien Broeks
  • Linde Braaf
  • Ron M. Kerkhoven
  • Freek Bot
  • Krijn van Groningen
  • Max Beijert
  • Bauke Ylstra
  • Daphne de Jongi

Nodal marginal zone lymphoma is a poorly defined entity in the World Health Organization classification, based largely on criteria of exclusion and the diagnosis often remains subjective. Follicular lymphoma lacking t(14;18) has similar characteristics which results in a major potential diagnostic overlap which this study aims to dissect. Four subgroups of lymphoma samples (n=56) were analyzed with high-resolution array comparative genome hybridization: nodal marginal zone lymphoma, t(14;18)-negative follicular lymphoma, localized t(14:18)-positive follicular lymphoma and disseminated t(14; 18)-positive follicular lymphoma. Gains on chromosomes 7, 8 and 12 were observed in all subgroups. The mean number of aberrations was higher in disseminated t(14; 18)-positive follicular lymphoma than in localized t(14: 18)-positive follicular lymphoma (P

Original languageEnglish
Pages (from-to)1921-1929
Number of pages9
JournalHaematologica
Volume98
Issue number12
Publication statusPublished - Dec-2013

    Keywords

  • COMPARATIVE GENOMIC HYBRIDIZATION, COPY NUMBER, BCL2 GENE, T(14/18), EXPRESSION, TRANSLOCATION, TRANSFORMATION, ABNORMALITIES, ABERRATIONS, MUTATIONS

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