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Differential switching to IgG and IgA in active smoking COPD patients and healthy controls

Brandsma, C-A., Kerstjens, H. A. M., van Geffen, W., Geerlings, M., Postma, D. S., Hylkema, M. N. & Timens, W., 1-Aug-2012, In : European Respiratory Journal. 40, 2, p. 313-321 9 p.

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DOI

Several studies have demonstrated the presence of B-cell follicles and autoantibodies in chronic obstructive pulmonary disease (COPD). It is unclear against which antigens this B-cell response is directed and whether it contributes to development or worsening of disease.

We assessed different B-cell subsets in blood and lung tissue from COPD patients and controls, and compared differences in B-cell responsiveness to stimulation with lung-specific antigens.

Active smoking induced an adaptive immune response with relatively high levels of (class-switched) memory B-cells in blood and immunoglobulin (Ig)G memory B-cells in the lung. COPD smokers showed more switching to IgG, whereas healthy smokers switched more to IgA. COPD patients had higher levels of memory B-cells in the lung and stimulation with lung-specific antigens induced higher numbers of anti-decorin antibody-producing cells in COPD patients compared with healthy controls.

Differential switching to IgG and IgA indicates that the adaptive immune response to smoke differs between COPD patients and healthy controls. A higher level of memory B-cells in the lungs of COPD patients may reflect an antigen-specific immune response, which could be directed against decorin, as suggested by the induction of anti-decorin antibody-producing cells in response to antigen-specific stimulation in COPD patients.

Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalEuropean Respiratory Journal
Volume40
Issue number2
Publication statusPublished - 1-Aug-2012

    Keywords

  • Cigarette smoke, decorin, immune response, lung tissue, memory B-cells, OBSTRUCTIVE PULMONARY-DISEASE, B-CELL, LYMPHOID FOLLICLES, T-CELLS, INDUCED EMPHYSEMA, I COLLAGEN, DECORIN, AUTOANTIBODIES, LUNG, AUTOIMMUNITY

ID: 5630900