Publication

Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome

Wirtz, PW., Sotodeh, M., Nijnuis, M., van Doorn, PA., van Engelen, BGM., Hintzen, RQ., de Kort, PLM., Kuks, JB., Twijnstra, A., de Visser, M., Visser, LH., Wokke, JH., Wintzen, AR. & Verschuuren, JJ., Dec-2002, In : JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 73, 6, p. 766-768 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Wirtz, PW., Sotodeh, M., Nijnuis, M., van Doorn, PA., van Engelen, BGM., Hintzen, RQ., de Kort, PLM., Kuks, JB., Twijnstra, A., de Visser, M., Visser, LH., Wokke, JH., Wintzen, AR., & Verschuuren, JJ. (2002). Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 73(6), 766-768.

Author

Wirtz, PW ; Sotodeh, M ; Nijnuis, M ; van Doorn, PA ; van Engelen, BGM ; Hintzen, RQ ; de Kort, PLM ; Kuks, JB ; Twijnstra, A ; de Visser, M ; Visser, LH ; Wokke, JH ; Wintzen, AR ; Verschuuren, JJ. / Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2002 ; Vol. 73, No. 6. pp. 766-768.

Harvard

Wirtz, PW, Sotodeh, M, Nijnuis, M, van Doorn, PA, van Engelen, BGM, Hintzen, RQ, de Kort, PLM, Kuks, JB, Twijnstra, A, de Visser, M, Visser, LH, Wokke, JH, Wintzen, AR & Verschuuren, JJ 2002, 'Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome', JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, vol. 73, no. 6, pp. 766-768.

Standard

Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. / Wirtz, PW; Sotodeh, M; Nijnuis, M; van Doorn, PA; van Engelen, BGM; Hintzen, RQ; de Kort, PLM; Kuks, JB; Twijnstra, A; de Visser, M; Visser, LH; Wokke, JH; Wintzen, AR; Verschuuren, JJ.

In: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol. 73, No. 6, 12.2002, p. 766-768.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Wirtz PW, Sotodeh M, Nijnuis M, van Doorn PA, van Engelen BGM, Hintzen RQ et al. Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2002 Dec;73(6):766-768.


BibTeX

@article{36f7418f3dac4ab7a4a12a8d8f16b904,
title = "Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome",
abstract = "Background: Myasthenia gravis and the Lambert-Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of myasthenia gravis or LEMS on clinical grounds may therefore be difficult.Objective: To compare the localisation of initial muscle weakness and the distribution of weakness at the time of maximum severity in patients with myasthenia gravis and LEMS.Subjects: 101 patients with myasthenia gravis and 38 patients with LEMS.Results: in myasthenia gravis, initial weakness involved extraocular muscles in 59%, bulbar muscles in 29%, and limb muscles in 12% of the patients. In LEMS no patient had ocular weakness, 5% had bulbar weakness, and 95% had weakness of the limbs as the first symptom (p <0.001), At the point of, maximum severity, weakness in myasthenia gravis was purely ocular in 25%, oculobulbar in 5%, restricted to the limbs in 2%, and present in both oculobulbar muscles and limbs in 68%. At this point, none of the LEMS patients had weakness restricted to extraocular or bulbar muscles (p = 0.002). The legs were affected in all LEMS patients, whereas in 12 patients with generalised myasthenia gravis limb weakness was restricted to the arms (p = 0.024).Conclusions: In a patient suspected to have a myasthenic syndrome whose first symptom is ocular weakness, LEMS is virtually excluded. Limb weakness confined to the arms is only found in generalised myasthenia gravis and not in LEMS. Muscle weakness in myasthenia gravis tends to develop in a craniocaudal direction, and in the opposite direction in LEMS.",
author = "PW Wirtz and M Sotodeh and M Nijnuis and {van Doorn}, PA and {van Engelen}, BGM and RQ Hintzen and {de Kort}, PLM and JB Kuks and A Twijnstra and {de Visser}, M and LH Visser and JH Wokke and AR Wintzen and JJ Verschuuren",
year = "2002",
month = dec,
language = "English",
volume = "73",
pages = "766--768",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "1468-330X",
publisher = "BMJ PUBLISHING GROUP",
number = "6",

}

RIS

TY - JOUR

T1 - Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome

AU - Wirtz, PW

AU - Sotodeh, M

AU - Nijnuis, M

AU - van Doorn, PA

AU - van Engelen, BGM

AU - Hintzen, RQ

AU - de Kort, PLM

AU - Kuks, JB

AU - Twijnstra, A

AU - de Visser, M

AU - Visser, LH

AU - Wokke, JH

AU - Wintzen, AR

AU - Verschuuren, JJ

PY - 2002/12

Y1 - 2002/12

N2 - Background: Myasthenia gravis and the Lambert-Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of myasthenia gravis or LEMS on clinical grounds may therefore be difficult.Objective: To compare the localisation of initial muscle weakness and the distribution of weakness at the time of maximum severity in patients with myasthenia gravis and LEMS.Subjects: 101 patients with myasthenia gravis and 38 patients with LEMS.Results: in myasthenia gravis, initial weakness involved extraocular muscles in 59%, bulbar muscles in 29%, and limb muscles in 12% of the patients. In LEMS no patient had ocular weakness, 5% had bulbar weakness, and 95% had weakness of the limbs as the first symptom (p <0.001), At the point of, maximum severity, weakness in myasthenia gravis was purely ocular in 25%, oculobulbar in 5%, restricted to the limbs in 2%, and present in both oculobulbar muscles and limbs in 68%. At this point, none of the LEMS patients had weakness restricted to extraocular or bulbar muscles (p = 0.002). The legs were affected in all LEMS patients, whereas in 12 patients with generalised myasthenia gravis limb weakness was restricted to the arms (p = 0.024).Conclusions: In a patient suspected to have a myasthenic syndrome whose first symptom is ocular weakness, LEMS is virtually excluded. Limb weakness confined to the arms is only found in generalised myasthenia gravis and not in LEMS. Muscle weakness in myasthenia gravis tends to develop in a craniocaudal direction, and in the opposite direction in LEMS.

AB - Background: Myasthenia gravis and the Lambert-Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of myasthenia gravis or LEMS on clinical grounds may therefore be difficult.Objective: To compare the localisation of initial muscle weakness and the distribution of weakness at the time of maximum severity in patients with myasthenia gravis and LEMS.Subjects: 101 patients with myasthenia gravis and 38 patients with LEMS.Results: in myasthenia gravis, initial weakness involved extraocular muscles in 59%, bulbar muscles in 29%, and limb muscles in 12% of the patients. In LEMS no patient had ocular weakness, 5% had bulbar weakness, and 95% had weakness of the limbs as the first symptom (p <0.001), At the point of, maximum severity, weakness in myasthenia gravis was purely ocular in 25%, oculobulbar in 5%, restricted to the limbs in 2%, and present in both oculobulbar muscles and limbs in 68%. At this point, none of the LEMS patients had weakness restricted to extraocular or bulbar muscles (p = 0.002). The legs were affected in all LEMS patients, whereas in 12 patients with generalised myasthenia gravis limb weakness was restricted to the arms (p = 0.024).Conclusions: In a patient suspected to have a myasthenic syndrome whose first symptom is ocular weakness, LEMS is virtually excluded. Limb weakness confined to the arms is only found in generalised myasthenia gravis and not in LEMS. Muscle weakness in myasthenia gravis tends to develop in a craniocaudal direction, and in the opposite direction in LEMS.

M3 - Article

VL - 73

SP - 766

EP - 768

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 1468-330X

IS - 6

ER -

ID: 4063502