Publication

Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma

Hesselink, M. S. K., Bocca, G., Hummel, Y. M., Brouwers, A. H., Burgerhof, J. G. M., van Dam, E. W. C. M., Gietema, J. A., Havekes, B., van den Heuvel-Eibrink, M. M., Corssmit, E. P. M., Kremer, L. C. M., Netea-Maier, R. T., van der Pal, H. J. H., Peeters, R. P., Plukker, J. T. M., Ronckers, C. M., van Santen, H. M., van der Meer, P., Links, T. P. & Tissing, W. J. E., 1-Dec-2017, In : Thyroid. 27, 12, p. 1481-1489 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hesselink, M. S. K., Bocca, G., Hummel, Y. M., Brouwers, A. H., Burgerhof, J. G. M., van Dam, E. W. C. M., ... Tissing, W. J. E. (2017). Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma. Thyroid, 27(12), 1481-1489. https://doi.org/10.1089/thy.2017.0383

Author

Hesselink, Marielle S. Klein ; Bocca, Gianni ; Hummel, Yoran M. ; Brouwers, Adrienne H. ; Burgerhof, Johannes G. M. ; van Dam, Eveline W. C. M. ; Gietema, Jourik A. ; Havekes, Bas ; van den Heuvel-Eibrink, Marry M. ; Corssmit, Eleonora P. M. ; Kremer, Leontien C. M. ; Netea-Maier, Romana T. ; van der Pal, Helena J. H. ; Peeters, Robin P. ; Plukker, John T. M. ; Ronckers, Cecile M. ; van Santen, Hanneke M. ; van der Meer, Peter ; Links, Thera P. ; Tissing, Wim J. E. / Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma. In: Thyroid. 2017 ; Vol. 27, No. 12. pp. 1481-1489.

Harvard

Hesselink, MSK, Bocca, G, Hummel, YM, Brouwers, AH, Burgerhof, JGM, van Dam, EWCM, Gietema, JA, Havekes, B, van den Heuvel-Eibrink, MM, Corssmit, EPM, Kremer, LCM, Netea-Maier, RT, van der Pal, HJH, Peeters, RP, Plukker, JTM, Ronckers, CM, van Santen, HM, van der Meer, P, Links, TP & Tissing, WJE 2017, 'Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma', Thyroid, vol. 27, no. 12, pp. 1481-1489. https://doi.org/10.1089/thy.2017.0383

Standard

Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma. / Hesselink, Marielle S. Klein; Bocca, Gianni; Hummel, Yoran M.; Brouwers, Adrienne H.; Burgerhof, Johannes G. M.; van Dam, Eveline W. C. M.; Gietema, Jourik A.; Havekes, Bas; van den Heuvel-Eibrink, Marry M.; Corssmit, Eleonora P. M.; Kremer, Leontien C. M.; Netea-Maier, Romana T.; van der Pal, Helena J. H.; Peeters, Robin P.; Plukker, John T. M.; Ronckers, Cecile M.; van Santen, Hanneke M.; van der Meer, Peter; Links, Thera P.; Tissing, Wim J. E.

In: Thyroid, Vol. 27, No. 12, 01.12.2017, p. 1481-1489.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hesselink MSK, Bocca G, Hummel YM, Brouwers AH, Burgerhof JGM, van Dam EWCM et al. Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma. Thyroid. 2017 Dec 1;27(12):1481-1489. https://doi.org/10.1089/thy.2017.0383


BibTeX

@article{8812e6f03d3941c990f21167bc501514,
title = "Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma",
abstract = "Introduction: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. Methods: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis 18 years and follow-up 5 years after diagnosis) treated in the Netherlands between 1970 and 2009. Assessment included echocardiography, plasma biomarkers (N-terminal pro-brain natriuretic peptide, high-sensitive troponin-T, galectin-3), and 24-hour Holter electrocardiography. Echocardiographic measurements were compared with retrospective data of 66 sex- and age-matched unaffected Dutch controls. Diastolic dysfunction was defined as an early diastolic septal and/or lateral tissue velocity (e) less than 2 SD of mean age-adjusted reference data. Results: The survivors (86.4{\%} women) had at DTC diagnosis a median age of 16 years. Median follow-up was 17 years. Left ventricular ejection fraction <50{\%} was found in one survivor, and median global longitudinal systolic strain was near normal. Diastolic dysfunction was present in 14 asymptomatic survivors (21.2{\%}). Overall, diastolic function of survivors was lower compared with controls (e′mean 14.5 versus 15.8 cm/s, P = 0.006). Older attained age and higher waist circumference were associated with decreased diastolic function, whereas thyrotropin levels and cumulative administered radioiodine dose were not. In survivors, biomarkers were not associated with diastolic dysfunction; atrial fibrillation was not observed.Conclusion: While systolic function is unaffected, diastolic dysfunction is frequently observed in asymptomatic long-term survivors of pediatric DTC, which may suggest early cardiac aging.",
keywords = "differentiated thyroid carcinoma, pediatric patients, late effects, cancer survivors, diastolic dysfunction, EXOGENOUS SUBCLINICAL HYPERTHYROIDISM, CHILDHOOD-CANCER, HEART-FAILURE, ASSOCIATION GUIDELINES, MANAGEMENT GUIDELINES, ADULT SURVIVORS, ECHOCARDIOGRAPHY, RECOMMENDATIONS, SUPPRESSION, HORMONE",
author = "Hesselink, {Marielle S. Klein} and Gianni Bocca and Hummel, {Yoran M.} and Brouwers, {Adrienne H.} and Burgerhof, {Johannes G. M.} and {van Dam}, {Eveline W. C. M.} and Gietema, {Jourik A.} and Bas Havekes and {van den Heuvel-Eibrink}, {Marry M.} and Corssmit, {Eleonora P. M.} and Kremer, {Leontien C. M.} and Netea-Maier, {Romana T.} and {van der Pal}, {Helena J. H.} and Peeters, {Robin P.} and Plukker, {John T. M.} and Ronckers, {Cecile M.} and {van Santen}, {Hanneke M.} and {van der Meer}, Peter and Links, {Thera P.} and Tissing, {Wim J. E.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1089/thy.2017.0383",
language = "English",
volume = "27",
pages = "1481--1489",
journal = "Thyroid",
issn = "1050-7256",
publisher = "MARY ANN LIEBERT, INC",
number = "12",

}

RIS

TY - JOUR

T1 - Diastolic Dysfunction is Common in Survivors of Pediatric Differentiated Thyroid Carcinoma

AU - Hesselink, Marielle S. Klein

AU - Bocca, Gianni

AU - Hummel, Yoran M.

AU - Brouwers, Adrienne H.

AU - Burgerhof, Johannes G. M.

AU - van Dam, Eveline W. C. M.

AU - Gietema, Jourik A.

AU - Havekes, Bas

AU - van den Heuvel-Eibrink, Marry M.

AU - Corssmit, Eleonora P. M.

AU - Kremer, Leontien C. M.

AU - Netea-Maier, Romana T.

AU - van der Pal, Helena J. H.

AU - Peeters, Robin P.

AU - Plukker, John T. M.

AU - Ronckers, Cecile M.

AU - van Santen, Hanneke M.

AU - van der Meer, Peter

AU - Links, Thera P.

AU - Tissing, Wim J. E.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Introduction: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. Methods: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis 18 years and follow-up 5 years after diagnosis) treated in the Netherlands between 1970 and 2009. Assessment included echocardiography, plasma biomarkers (N-terminal pro-brain natriuretic peptide, high-sensitive troponin-T, galectin-3), and 24-hour Holter electrocardiography. Echocardiographic measurements were compared with retrospective data of 66 sex- and age-matched unaffected Dutch controls. Diastolic dysfunction was defined as an early diastolic septal and/or lateral tissue velocity (e) less than 2 SD of mean age-adjusted reference data. Results: The survivors (86.4% women) had at DTC diagnosis a median age of 16 years. Median follow-up was 17 years. Left ventricular ejection fraction <50% was found in one survivor, and median global longitudinal systolic strain was near normal. Diastolic dysfunction was present in 14 asymptomatic survivors (21.2%). Overall, diastolic function of survivors was lower compared with controls (e′mean 14.5 versus 15.8 cm/s, P = 0.006). Older attained age and higher waist circumference were associated with decreased diastolic function, whereas thyrotropin levels and cumulative administered radioiodine dose were not. In survivors, biomarkers were not associated with diastolic dysfunction; atrial fibrillation was not observed.Conclusion: While systolic function is unaffected, diastolic dysfunction is frequently observed in asymptomatic long-term survivors of pediatric DTC, which may suggest early cardiac aging.

AB - Introduction: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. Methods: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis 18 years and follow-up 5 years after diagnosis) treated in the Netherlands between 1970 and 2009. Assessment included echocardiography, plasma biomarkers (N-terminal pro-brain natriuretic peptide, high-sensitive troponin-T, galectin-3), and 24-hour Holter electrocardiography. Echocardiographic measurements were compared with retrospective data of 66 sex- and age-matched unaffected Dutch controls. Diastolic dysfunction was defined as an early diastolic septal and/or lateral tissue velocity (e) less than 2 SD of mean age-adjusted reference data. Results: The survivors (86.4% women) had at DTC diagnosis a median age of 16 years. Median follow-up was 17 years. Left ventricular ejection fraction <50% was found in one survivor, and median global longitudinal systolic strain was near normal. Diastolic dysfunction was present in 14 asymptomatic survivors (21.2%). Overall, diastolic function of survivors was lower compared with controls (e′mean 14.5 versus 15.8 cm/s, P = 0.006). Older attained age and higher waist circumference were associated with decreased diastolic function, whereas thyrotropin levels and cumulative administered radioiodine dose were not. In survivors, biomarkers were not associated with diastolic dysfunction; atrial fibrillation was not observed.Conclusion: While systolic function is unaffected, diastolic dysfunction is frequently observed in asymptomatic long-term survivors of pediatric DTC, which may suggest early cardiac aging.

KW - differentiated thyroid carcinoma

KW - pediatric patients

KW - late effects

KW - cancer survivors

KW - diastolic dysfunction

KW - EXOGENOUS SUBCLINICAL HYPERTHYROIDISM

KW - CHILDHOOD-CANCER

KW - HEART-FAILURE

KW - ASSOCIATION GUIDELINES

KW - MANAGEMENT GUIDELINES

KW - ADULT SURVIVORS

KW - ECHOCARDIOGRAPHY

KW - RECOMMENDATIONS

KW - SUPPRESSION

KW - HORMONE

U2 - 10.1089/thy.2017.0383

DO - 10.1089/thy.2017.0383

M3 - Article

VL - 27

SP - 1481

EP - 1489

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 12

ER -

ID: 50181495