Publication

Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield

de Jesus, F. M. M., Kwee, T. C., Kahle, X. U., Nijland, M., van Meerten, T., Huls, G., Dierckx, R. A. J. O., Rosati, S., Diepstra, A., van der Bij, W., Verschuuren, E. A. M., Glaudemans, A. W. J. M. & Noordzij, W., Mar-2020, In : European Journal of Nuclear Medicine and Molecular Imaging. 47, 3, p. 529-536 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Jesus, F. M. M., Kwee, T. C., Kahle, X. U., Nijland, M., van Meerten, T., Huls, G., ... Noordzij, W. (2020). Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield. European Journal of Nuclear Medicine and Molecular Imaging, 47(3), 529-536. https://doi.org/10.1007/s00259-019-04481-7

Author

de Jesus, F M Montes ; Kwee, T C ; Kahle, X U ; Nijland, M ; van Meerten, T ; Huls, G ; Dierckx, R A J O ; Rosati, S ; Diepstra, A ; van der Bij, W ; Verschuuren, E A M ; Glaudemans, A W J M ; Noordzij, W. / Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield. In: European Journal of Nuclear Medicine and Molecular Imaging. 2020 ; Vol. 47, No. 3. pp. 529-536.

Harvard

de Jesus, FMM, Kwee, TC, Kahle, XU, Nijland, M, van Meerten, T, Huls, G, Dierckx, RAJO, Rosati, S, Diepstra, A, van der Bij, W, Verschuuren, EAM, Glaudemans, AWJM & Noordzij, W 2020, 'Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield', European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 3, pp. 529-536. https://doi.org/10.1007/s00259-019-04481-7

Standard

Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield. / de Jesus, F M Montes; Kwee, T C; Kahle, X U; Nijland, M; van Meerten, T; Huls, G; Dierckx, R A J O; Rosati, S; Diepstra, A; van der Bij, W; Verschuuren, E A M; Glaudemans, A W J M; Noordzij, W.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 47, No. 3, 03.2020, p. 529-536.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Jesus FMM, Kwee TC, Kahle XU, Nijland M, van Meerten T, Huls G et al. Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield. European Journal of Nuclear Medicine and Molecular Imaging. 2020 Mar;47(3):529-536. https://doi.org/10.1007/s00259-019-04481-7


BibTeX

@article{25c6028b99604300a9cbc3e6cc92679a,
title = "Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield",
abstract = "PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after solid organ and hematopoietic stem cell transplantation, requiring a timely and accurate diagnosis. In this study, we evaluated the diagnostic performance of FDG-PET/CT in patients with suspected PTLD and examined if lactate dehydrogenase (LDH) levels, Epstein-Barr virus (EBV) load, or timing of FDG-PET/CT relate to detection performance of FDG-PET/CT.METHODS: This retrospective study included 91 consecutive patients with clinical suspicion of PTLD and a total of 97 FDG-PET/CT scans within an 8-year period. Pathology reports and a 2-year follow-up were used as the reference standard. Diagnostic performance of FDG-PET/CT for detection of PTLD as well as logistic regression analysis for factors expected to affect diagnostic yield were assessed.RESULTS: The diagnosis of PTLD was established in 34 patients (35{\%}). Fifty-seven FDG-PET/CT scans (59{\%}) were true negative, 29 (30{\%}) were true positive, 6 (6{\%}) false positive, and 5 (5{\%}) false negative. Sensitivity of FDG-PET/CT for the detection of PTLD was 85{\%}, specificity 90{\%}, positive predictive value 83{\%}, and negative predictive value 92{\%}, with good inter-observer variability (k = 0.78). Of the parameters hypothesized to be associated with a true positive FDG-PET/CT result for the diagnosis of PTLD, only LDH was statistically significant (OR 1.03, p = 0.04).CONCLUSION: FDG-PET/CT has a good diagnostic performance in patients suspected of PTLD, with a good inter-observer agreement. Only LDH levels seemed to influence the detection performance of FDG-PET/CT. EBV-DNA load and timing of FDG-PET/CT after transplantation did not affect FDG-PET/CT diagnostic yield.",
keywords = "Post-transplant lymphoproliferative disorder, F-18-Fluoro-D-deoxyglucose positron emission tomography, FDG-PET, CT, Diagnosis, POSITRON-EMISSION-TOMOGRAPHY, B-CELL LYMPHOMA, BARR VIRAL LOAD, RISK, RECIPIENTS, SURVIVAL",
author = "{de Jesus}, {F M Montes} and Kwee, {T C} and Kahle, {X U} and M Nijland and {van Meerten}, T and G Huls and Dierckx, {R A J O} and S Rosati and A Diepstra and {van der Bij}, W and Verschuuren, {E A M} and Glaudemans, {A W J M} and W Noordzij",
year = "2020",
month = "3",
doi = "10.1007/s00259-019-04481-7",
language = "English",
volume = "47",
pages = "529--536",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "SPRINGER",
number = "3",

}

RIS

TY - JOUR

T1 - Diagnostic performance of FDG-PET/CT of post-transplant lymphoproliferative disorder and factors affecting diagnostic yield

AU - de Jesus, F M Montes

AU - Kwee, T C

AU - Kahle, X U

AU - Nijland, M

AU - van Meerten, T

AU - Huls, G

AU - Dierckx, R A J O

AU - Rosati, S

AU - Diepstra, A

AU - van der Bij, W

AU - Verschuuren, E A M

AU - Glaudemans, A W J M

AU - Noordzij, W

PY - 2020/3

Y1 - 2020/3

N2 - PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after solid organ and hematopoietic stem cell transplantation, requiring a timely and accurate diagnosis. In this study, we evaluated the diagnostic performance of FDG-PET/CT in patients with suspected PTLD and examined if lactate dehydrogenase (LDH) levels, Epstein-Barr virus (EBV) load, or timing of FDG-PET/CT relate to detection performance of FDG-PET/CT.METHODS: This retrospective study included 91 consecutive patients with clinical suspicion of PTLD and a total of 97 FDG-PET/CT scans within an 8-year period. Pathology reports and a 2-year follow-up were used as the reference standard. Diagnostic performance of FDG-PET/CT for detection of PTLD as well as logistic regression analysis for factors expected to affect diagnostic yield were assessed.RESULTS: The diagnosis of PTLD was established in 34 patients (35%). Fifty-seven FDG-PET/CT scans (59%) were true negative, 29 (30%) were true positive, 6 (6%) false positive, and 5 (5%) false negative. Sensitivity of FDG-PET/CT for the detection of PTLD was 85%, specificity 90%, positive predictive value 83%, and negative predictive value 92%, with good inter-observer variability (k = 0.78). Of the parameters hypothesized to be associated with a true positive FDG-PET/CT result for the diagnosis of PTLD, only LDH was statistically significant (OR 1.03, p = 0.04).CONCLUSION: FDG-PET/CT has a good diagnostic performance in patients suspected of PTLD, with a good inter-observer agreement. Only LDH levels seemed to influence the detection performance of FDG-PET/CT. EBV-DNA load and timing of FDG-PET/CT after transplantation did not affect FDG-PET/CT diagnostic yield.

AB - PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after solid organ and hematopoietic stem cell transplantation, requiring a timely and accurate diagnosis. In this study, we evaluated the diagnostic performance of FDG-PET/CT in patients with suspected PTLD and examined if lactate dehydrogenase (LDH) levels, Epstein-Barr virus (EBV) load, or timing of FDG-PET/CT relate to detection performance of FDG-PET/CT.METHODS: This retrospective study included 91 consecutive patients with clinical suspicion of PTLD and a total of 97 FDG-PET/CT scans within an 8-year period. Pathology reports and a 2-year follow-up were used as the reference standard. Diagnostic performance of FDG-PET/CT for detection of PTLD as well as logistic regression analysis for factors expected to affect diagnostic yield were assessed.RESULTS: The diagnosis of PTLD was established in 34 patients (35%). Fifty-seven FDG-PET/CT scans (59%) were true negative, 29 (30%) were true positive, 6 (6%) false positive, and 5 (5%) false negative. Sensitivity of FDG-PET/CT for the detection of PTLD was 85%, specificity 90%, positive predictive value 83%, and negative predictive value 92%, with good inter-observer variability (k = 0.78). Of the parameters hypothesized to be associated with a true positive FDG-PET/CT result for the diagnosis of PTLD, only LDH was statistically significant (OR 1.03, p = 0.04).CONCLUSION: FDG-PET/CT has a good diagnostic performance in patients suspected of PTLD, with a good inter-observer agreement. Only LDH levels seemed to influence the detection performance of FDG-PET/CT. EBV-DNA load and timing of FDG-PET/CT after transplantation did not affect FDG-PET/CT diagnostic yield.

KW - Post-transplant lymphoproliferative disorder

KW - F-18-Fluoro-D-deoxyglucose positron emission tomography

KW - FDG-PET

KW - CT

KW - Diagnosis

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - B-CELL LYMPHOMA

KW - BARR VIRAL LOAD

KW - RISK

KW - RECIPIENTS

KW - SURVIVAL

U2 - 10.1007/s00259-019-04481-7

DO - 10.1007/s00259-019-04481-7

M3 - Article

VL - 47

SP - 529

EP - 536

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 3

ER -

ID: 94899316