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Diagnostic performance of coronary CT angiography for stenosis detection according to calcium score: systematic review and meta-analysis

den Dekker, M., de Smet, K., de Bock, G. H., Tio, R. A., Oudkerk, M. & Vliegenthart, R., Dec-2012, In : European Radiology. 22, 12, p. 2688-2698 11 p.

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  • Diagnostic performance of coronary CT angiography

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DOI

Objectives A systematic review and meta-analysis to assess sensitivity and specificity of coronary CT angiography (CCTA) for significant stenosis at different degrees of coronary calcification.

Methods A literature search was performed including studies describing test characteristics of CCTA for significant stenosis, performed with at least 16-MDCT and according to calcium score (CS). Invasive coronary angiography was the reference standard. Pooled sensitivity and specificity of CCTA by CS categories and CT equipment were calculated.

Results Of 14,121 articles, 51 studies reported on the impact of calcium scoring on diagnostic performance of CCTA and could be included in the systematic review. Twenty-seven of these studies (5,203 participants) were suitable for meta-analysis. On a patient-basis, sensitivity of CCTA for significant stenosis was 95.8, 95.6, 97.6 and 99.0% for CS 0-100, 101-400, 401-1,000 and > 1,000 respectively. Specificity was 91.2, 88.2, 50.6 and 84.0% respectively. Specificity of CCTA was significantly lower for CS 401-1,000 due to lack of patients without significant stenosis. Sensitivity and specificity of 16-MDCT were significantly lower compared to more modern CT systems.

Conclusions Even in cases of severe coronary calcification, sensitivity and specificity of CCTA for significant stenosis are high. With 64-MDCT and newer CT systems, a CS cut-off for performing CCTA no longer seems indicated.

Key Points

. Decisions about performing coronary CT angiography (CCTA) sometimes depend on calcium scoring.

. CCTA is highly sensitive for coronary stenosis.

. With 16-MDCT, however, heavy calcification reduces specificity for significant stenosis.

. For 64-MDCT (and above), CCTA has high specificity, even with severe coronary calcification.

Original languageEnglish
Pages (from-to)2688-2698
Number of pages11
JournalEuropean Radiology
Volume22
Issue number12
Publication statusPublished - Dec-2012

    Keywords

  • Computed tomography angiography, Calcium score, Coronary artery disease, Meta-analysis, Systematic review, SPIRAL COMPUTED-TOMOGRAPHY, DUAL-SOURCE CT, NONCORONARY CARDIAC-SURGERY, NORTH-AMERICAN-SOCIETY, HEART-RATE-VARIABILITY, ACUTE CHEST-PAIN, ARTERY-DISEASE, IMAGE QUALITY, MAGNETIC-RESONANCE, ACCURACY

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