Diagnosis and management of aspergillosis in the Netherlands: a national surveyLestrade, P. P. A., Meis, J. F., Arends, J. P., van der Beek, M. T., de Brauwer, E., van Dijk, K., de Greeff, S. C., Haas, P-J., Hodiamont, C. J., Kuijper, E. J., Leenstra, T., Muller, A. E., Lashof, A. M. L. O., Rijnders, B. J., Roelofsen, E., Rozemeijer, W., Tersmette, M., Terveer, E. M., Verduin, C. M., Wolfhagen, M. J. H. M., Melchers, W. J. G. & Verweij, P. E., Feb-2016, In : Mycoses. 59, 2, p. 101-107 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.
|Number of pages||7|
|Publication status||Published - Feb-2016|
- Aspergillosis, azole resistance, treatment, AZOLE RESISTANCE, TR34/L98H MUTATIONS, TRIAZOLE RESISTANCE, FUMIGATUS, SURVEILLANCE, ENVIRONMENT, PREVALENCE, FREQUENCY, MECHANISM, STRAINS