Publication

Diagnosis and management of aspergillosis in the Netherlands: a national survey

Lestrade, P. P. A., Meis, J. F., Arends, J. P., van der Beek, M. T., de Brauwer, E., van Dijk, K., de Greeff, S. C., Haas, P-J., Hodiamont, C. J., Kuijper, E. J., Leenstra, T., Muller, A. E., Lashof, A. M. L. O., Rijnders, B. J., Roelofsen, E., Rozemeijer, W., Tersmette, M., Terveer, E. M., Verduin, C. M., Wolfhagen, M. J. H. M., Melchers, W. J. G. & Verweij, P. E., Feb-2016, In : Mycoses. 59, 2, p. 101-107 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Diagnosis and management of aspergillosis in the Netherlands_ a national survey

    Final publisher's version, 112 KB, PDF document

    Request copy

DOI

  • Pieter P. A. Lestrade
  • Jacques F. Meis
  • Jan P. Arends
  • Martha T. van der Beek
  • Els de Brauwer
  • Karin van Dijk
  • Sabine C. de Greeff
  • Pieter-Jan Haas
  • Caspar J. Hodiamont
  • Ed J. Kuijper
  • Tjalling Leenstra
  • Anouk E. Muller
  • Astrid M. L. Oude Lashof
  • Bart J. Rijnders
  • Eveline Roelofsen
  • Wouter Rozemeijer
  • Mathijs Tersmette
  • Elizabeth M. Terveer
  • Cees M. Verduin
  • Maurice J. H. M. Wolfhagen
  • Willem J. G. Melchers
  • Paul E. Verweij

A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalMycoses
Volume59
Issue number2
Publication statusPublished - Feb-2016

    Keywords

  • Aspergillosis, azole resistance, treatment, AZOLE RESISTANCE, TR34/L98H MUTATIONS, TRIAZOLE RESISTANCE, FUMIGATUS, SURVEILLANCE, ENVIRONMENT, PREVALENCE, FREQUENCY, MECHANISM, STRAINS

ID: 41552938