Development of the Inhibitors that Target the PD-1/PD-L1 Interaction-A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

Guzik, K., Tomala, M., Muszak, D., Konieczny, M., Hec, A., Błaszkiewicz, U., Pustuła, M., Butera, R., Dömling, A. & Holak, T. A., 30-May-2019, In : Molecules. 24, 11, 30 p., 2071.

Research output: Contribution to journalReview articleAcademicpeer-review

Cancer immunotherapy based on antibodies targeting the immune checkpoint PD-1/PD-L1 pathway has seen unprecedented clinical responses and constitutes the new paradigm in cancer therapy. The antibody-based immunotherapies have several limitations such as high production cost of the antibodies or their long half-life. Small-molecule inhibitors of the PD-1/PD-L1 interaction have been highly anticipated as a promising alternative or complementary therapeutic to the monoclonal antibodies (mAbs). Currently, the field of developing anti-PD-1/PD-L1 small-molecule inhibitors is intensively explored. In this paper, we review anti-PD-1/PD-L1 small-molecule and peptide-based inhibitors and discuss recent structural and preclinical/clinical aspects of their development. Discovery of the therapeutics based on small-molecule inhibitors of the PD-1/PD-L1 interaction represents a promising but challenging perspective in cancer treatment.

Original languageEnglish
Article number2071
Number of pages30
Issue number11
Publication statusPublished - 30-May-2019

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