Publication

Development of postural control in infancy in cerebral palsy and cystic periventricular leukomalacia

Boxum, A. G., Dijkstra, L-J., la Bastide-van Gemert, S., Hamer, E. G., Hielkema, T., Reinders-Messelink, H. A. & Hadders-Algra, M., Jul-2018, In : Research in Developmental Disabilities. 78, p. 66-77 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Development of postural control in infancy in cerebral palsy and cystic periventricular leukomalacia

    Final publisher's version, 903 KB, PDF document

DOI

Background: Development of postural problems in Cerebral Palsy (CP) is largely unknown. Postural muscle activity is organized into two levels: 1) direction-specificity; 2) fine-tuning of direction-specific activity.

Aim: To study development of postural control until 21 months corrected age in subgroups of infants at very high-risk (VHR) of CP: a) with and without CP at 21 months; b) with and without cystic periventricular leukomalacia (cPVL), the brain lesion with highest risk of CP.

Methods and procedures: Longitudinal electromyography recordings of postural muscles during reaching were made in 38 VHR-infants (severe brain lesion or clear neurological signs) between 4.7 and 22.6 months (18 CP, of which 8 with cPVL). Developmental trajectories were calculated using linear mixed effect models.

Outcomes and results: VHR-infants with and without CP showed virtually similar postural development throughout infancy. The subgroup of VHR-infants with cPVL improved performance in direction-specificity with increasing age, while they performed throughout infancy worse in fine-tuning of postural adjustments than infants without cPVL.

Conclusions and implications: VHR-infants with and without CP have a similar postural development that differs from published trajectories of typically developing infants. Infants with cPVL present from early age onwards dysfunctions in fine-tuning of postural adjustments; they focus on direction-specificity.

Original languageEnglish
Pages (from-to)66-77
Number of pages12
JournalResearch in Developmental Disabilities
Volume78
Early online date2018
Publication statusPublished - Jul-2018

    Keywords

  • Postural control, Infancy, Cerebral palsy, Cystic periventricular leukomalacia, Electromyography, MINOR NEUROLOGICAL DYSFUNCTION, RANDOMIZED-CONTROLLED-TRIAL, HIGH-RISK, EXTERNAL PERTURBATIONS, PRETERM CHILDREN, SPASTIC DIPLEGIA, ADJUSTMENTS, MOTOR, CLASSIFICATION, MOVEMENTS

ID: 60728905