Development of orodispersible films with selected Indonesian medicinal plant extracts

Visser, J., Eugresya, G., Hinrichs, W., Tjandrawinata, R., Avanti, C., Frijlink, H. W. & Woerdenbag, H., 1-Mar-2017, In : Journal of Herbal Medicine. 7, p. 37-46 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard


  • Development of orodispersible films with selected Indonesian medicinal plant extracts

    Final publisher's version, 757 KB, PDF document

    Request copy


This study focused on the incorporation into orodispersible films (ODFs) of the dried extracts of five selected Indonesian medicinal plants: Lagerstroemia speciosa (L.) Pers. (LS), Phyllanthus niruri L. (PN), Cinnamomum burmanii Blume (CB), Zingiber officinale Roscoe (ZO) and Phaleria macrocarpa (Scheff.) Boerl (PM). Suitable formulae for solvent casting were developed to produce extract containing films with either a combination of hypromellose (HPMC) with carbomer 974P or only hydroxypropyl cellulose (HPC) as film forming agent. Each extract and dose in a formulation rendered different ODF characteristics. Extracts of ZO and CB and a low dose of PM extract (5 mg) could be formulated into an ODF containing HPMC with carbomer 974P. For extracts of LS, PN and high doses of PM extract HPC were the most suitable film forming agents. For each extract a different maximum load in a film was found, up to maximum 30 mg for extracts of LS and PN. Good products were obtained with 5 mg and 10 mg of each extract. The quality of the produced ODFs was tested organoleptically, and characterized by determination of uniformity of weight, thickness, disintegration time, surface pH, crystallinity, mechanical properties, water content, residual ethanol, dynamic vapour sorption, physical stability and control of the qualitative profiling of extract composition in the film. Thin layer chromatography indicated that all five extracts remained chemically unaffected during ODF production. In conclusion, ODFs are a suitable novel dosage form for herbal extracts, provided that tailor-made formulations are developed for each extract and each dose. (C) 2016 Elsevier GmbH. All rights reserved.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalJournal of Herbal Medicine
Publication statusPublished - 1-Mar-2017


  • Orodispersible film, Dried herbal extracts, Product development, Extract load, Product quality, BUCCAL FILMS, FORMULATION

ID: 39191000