Publication

Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study

Maarsingh, O. R., Heymans, M. W., Verhaak, P. F., Penninx, B. W. J. H. & Comijs, H. C., 1-Aug-2018, In : Journal of Affective Disorders. 235, p. 105-113 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Maarsingh, O. R., Heymans, M. W., Verhaak, P. F., Penninx, B. W. J. H., & Comijs, H. C. (2018). Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study. Journal of Affective Disorders, 235, 105-113. https://doi.org/10.1016/j.jad.2018.04.026

Author

Maarsingh, O. R. ; Heymans, M. W. ; Verhaak, P. F. ; Penninx, B. W. J. H. ; Comijs, H. C. / Development and external validation of a prediction rule for an unfavorable course of late-life depression : A multicenter cohort study. In: Journal of Affective Disorders. 2018 ; Vol. 235. pp. 105-113.

Harvard

Maarsingh, OR, Heymans, MW, Verhaak, PF, Penninx, BWJH & Comijs, HC 2018, 'Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study', Journal of Affective Disorders, vol. 235, pp. 105-113. https://doi.org/10.1016/j.jad.2018.04.026

Standard

Development and external validation of a prediction rule for an unfavorable course of late-life depression : A multicenter cohort study. / Maarsingh, O. R.; Heymans, M. W.; Verhaak, P. F.; Penninx, B. W. J. H.; Comijs, H. C.

In: Journal of Affective Disorders, Vol. 235, 01.08.2018, p. 105-113.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Maarsingh OR, Heymans MW, Verhaak PF, Penninx BWJH, Comijs HC. Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study. Journal of Affective Disorders. 2018 Aug 1;235:105-113. https://doi.org/10.1016/j.jad.2018.04.026


BibTeX

@article{73fcf88310e54ca8b2cc6630fc117061,
title = "Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study",
abstract = "Background: Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression.Methods: For development and internal validation of the model, we used The Netherlands Study of Depression in Older Persons (NESDO) data. We included participants with a major depressive disorder (MDD) at baseline (n = 270; 60-90 years), assessed with the Composite International Diagnostic Interview (CIDI). For external validation of the model, we used The Netherlands Study of Depression and Anxiety (NESDA) data (n = 197; 50-66 years). The outcome was MDD after 2 years of follow-up, assessed with the CIDI. Candidate predictors concerned sociodemographics, psychopathology, physical symptoms, medication, psychological determinants, and healthcare setting. Model performance was assessed by calculating calibration and discrimination.Results: 111 subjects (41.1{\%}) had MDD after 2 years of follow-up. Independent predictors of MDD after 2 years were (older) age, (early) onset of depression, severity of depression, anxiety symptoms, comorbid anxiety disorder, fatigue, and loneliness. The final model showed good calibration and reasonable discrimination (AUC of 0.75; 0.70 after external validation). The strongest individual predictor was severity of depression (AUC of 0.69; 0.68 after external validation).Limitations: The model was developed and validated in The Netherlands, which could affect the cross-country generalizability.Conclusions: Based on rather simple clinical indicators, it is possible to predict the 2-year course of MDD. The prediction rule can be used for monitoring MDD patients and identifying those at risk of an unfavourable outcome.",
keywords = "Depressive disorder, Older adults, Predictors, Prognosis, DIAGNOSTIC INTERVIEW CIDI, PRIMARY-CARE PATIENTS, MENTAL-HEALTH SURVEY, ANXIETY NESDA, OLDER-ADULTS, RISK-FACTORS, PSYCHOMETRIC PROPERTIES, REGRESSION-ANALYSIS, GENERAL-POPULATION, 2-YEAR COURSE",
author = "Maarsingh, {O. R.} and Heymans, {M. W.} and Verhaak, {P. F.} and Penninx, {B. W. J. H.} and Comijs, {H. C.}",
year = "2018",
month = "8",
day = "1",
doi = "10.1016/j.jad.2018.04.026",
language = "English",
volume = "235",
pages = "105--113",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Development and external validation of a prediction rule for an unfavorable course of late-life depression

T2 - A multicenter cohort study

AU - Maarsingh, O. R.

AU - Heymans, M. W.

AU - Verhaak, P. F.

AU - Penninx, B. W. J. H.

AU - Comijs, H. C.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression.Methods: For development and internal validation of the model, we used The Netherlands Study of Depression in Older Persons (NESDO) data. We included participants with a major depressive disorder (MDD) at baseline (n = 270; 60-90 years), assessed with the Composite International Diagnostic Interview (CIDI). For external validation of the model, we used The Netherlands Study of Depression and Anxiety (NESDA) data (n = 197; 50-66 years). The outcome was MDD after 2 years of follow-up, assessed with the CIDI. Candidate predictors concerned sociodemographics, psychopathology, physical symptoms, medication, psychological determinants, and healthcare setting. Model performance was assessed by calculating calibration and discrimination.Results: 111 subjects (41.1%) had MDD after 2 years of follow-up. Independent predictors of MDD after 2 years were (older) age, (early) onset of depression, severity of depression, anxiety symptoms, comorbid anxiety disorder, fatigue, and loneliness. The final model showed good calibration and reasonable discrimination (AUC of 0.75; 0.70 after external validation). The strongest individual predictor was severity of depression (AUC of 0.69; 0.68 after external validation).Limitations: The model was developed and validated in The Netherlands, which could affect the cross-country generalizability.Conclusions: Based on rather simple clinical indicators, it is possible to predict the 2-year course of MDD. The prediction rule can be used for monitoring MDD patients and identifying those at risk of an unfavourable outcome.

AB - Background: Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression.Methods: For development and internal validation of the model, we used The Netherlands Study of Depression in Older Persons (NESDO) data. We included participants with a major depressive disorder (MDD) at baseline (n = 270; 60-90 years), assessed with the Composite International Diagnostic Interview (CIDI). For external validation of the model, we used The Netherlands Study of Depression and Anxiety (NESDA) data (n = 197; 50-66 years). The outcome was MDD after 2 years of follow-up, assessed with the CIDI. Candidate predictors concerned sociodemographics, psychopathology, physical symptoms, medication, psychological determinants, and healthcare setting. Model performance was assessed by calculating calibration and discrimination.Results: 111 subjects (41.1%) had MDD after 2 years of follow-up. Independent predictors of MDD after 2 years were (older) age, (early) onset of depression, severity of depression, anxiety symptoms, comorbid anxiety disorder, fatigue, and loneliness. The final model showed good calibration and reasonable discrimination (AUC of 0.75; 0.70 after external validation). The strongest individual predictor was severity of depression (AUC of 0.69; 0.68 after external validation).Limitations: The model was developed and validated in The Netherlands, which could affect the cross-country generalizability.Conclusions: Based on rather simple clinical indicators, it is possible to predict the 2-year course of MDD. The prediction rule can be used for monitoring MDD patients and identifying those at risk of an unfavourable outcome.

KW - Depressive disorder

KW - Older adults

KW - Predictors

KW - Prognosis

KW - DIAGNOSTIC INTERVIEW CIDI

KW - PRIMARY-CARE PATIENTS

KW - MENTAL-HEALTH SURVEY

KW - ANXIETY NESDA

KW - OLDER-ADULTS

KW - RISK-FACTORS

KW - PSYCHOMETRIC PROPERTIES

KW - REGRESSION-ANALYSIS

KW - GENERAL-POPULATION

KW - 2-YEAR COURSE

U2 - 10.1016/j.jad.2018.04.026

DO - 10.1016/j.jad.2018.04.026

M3 - Article

VL - 235

SP - 105

EP - 113

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 62678364