Publication

Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system

Neels, O. C., Jager, P. L., Koopmans, K. P., Eriks, E., de Vries, E. G. E., Kema, I. P. & Elsinga, P. H., Sep-2006, In : JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 49, 10, p. 889-895 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Neels, O. C., Jager, P. L., Koopmans, K. P., Eriks, E., de Vries, E. G. E., Kema, I. P., & Elsinga, P. H. (2006). Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 49(10), 889-895. https://doi.org/10.1002/jlcr.1110

Author

Neels, O. C. ; Jager, P. L. ; Koopmans, K. P. ; Eriks, E. ; de Vries, E. G. E. ; Kema, I. P. ; Elsinga, P. H. / Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system. In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2006 ; Vol. 49, No. 10. pp. 889-895.

Harvard

Neels, OC, Jager, PL, Koopmans, KP, Eriks, E, de Vries, EGE, Kema, IP & Elsinga, PH 2006, 'Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system', JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 49, no. 10, pp. 889-895. https://doi.org/10.1002/jlcr.1110

Standard

Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system. / Neels, O. C.; Jager, P. L.; Koopmans, K. P.; Eriks, E.; de Vries, E. G. E.; Kema, I. P.; Elsinga, P. H.

In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol. 49, No. 10, 09.2006, p. 889-895.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Neels OC, Jager PL, Koopmans KP, Eriks E, de Vries EGE, Kema IP et al. Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2006 Sep;49(10):889-895. https://doi.org/10.1002/jlcr.1110


BibTeX

@article{ecd1087f367f432896be6efcff912128,
title = "Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system",
abstract = "Precise staging of neuroendocrine tumors (NET) using positron emission tomography (PET) tracers visualizing their specific metabolic activity is of interest. Besides [F-18]FDOPA, staging NET with carbon-11 labeled 5-hydroxytryptophan (5-HTP) is reported in recent literature. We implemented the multi-enzymatic synthesis of enantiomerically pure [C-11]-L-5-HTP on a Zymark robotic system to compare both tracers in patient studies. [C-11]-5-HTP can be synthesized in up to 24{\%} radiochemical yields (EOB). Average specific activity is 44000 GBq/mmol in ca. 50 min from [C-11]methyl iodide in radiochemical purities > 99 {\%}. The synthesis of 5-HTP is difficult due to its multi-enzymatic reaction steps but typical yields can be achieved of ca. 400 MBq. [C-11]-5-HTP is now reliably used in ongoing studies for staging NET. Copyright (c) 2006 John Wiley & Sons, Ltd.",
keywords = "POSITRON-EMISSION-TOMOGRAPHY, CARCINOID-TUMORS, L-TRYPTOPHAN, 5-HYDROXY-L-TRYPTOPHAN, ACIDS",
author = "Neels, {O. C.} and Jager, {P. L.} and Koopmans, {K. P.} and E. Eriks and {de Vries}, {E. G. E.} and Kema, {I. P.} and Elsinga, {P. H.}",
year = "2006",
month = "9",
doi = "10.1002/jlcr.1110",
language = "English",
volume = "49",
pages = "889--895",
journal = "JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS",
issn = "0362-4803",
publisher = "Wiley",
number = "10",

}

RIS

TY - JOUR

T1 - Develoment of a reliable remote-controlled synthesis of beta-[C-11]-5-hydroxy-L-tryptophan on a Zymark robotic system

AU - Neels, O. C.

AU - Jager, P. L.

AU - Koopmans, K. P.

AU - Eriks, E.

AU - de Vries, E. G. E.

AU - Kema, I. P.

AU - Elsinga, P. H.

PY - 2006/9

Y1 - 2006/9

N2 - Precise staging of neuroendocrine tumors (NET) using positron emission tomography (PET) tracers visualizing their specific metabolic activity is of interest. Besides [F-18]FDOPA, staging NET with carbon-11 labeled 5-hydroxytryptophan (5-HTP) is reported in recent literature. We implemented the multi-enzymatic synthesis of enantiomerically pure [C-11]-L-5-HTP on a Zymark robotic system to compare both tracers in patient studies. [C-11]-5-HTP can be synthesized in up to 24% radiochemical yields (EOB). Average specific activity is 44000 GBq/mmol in ca. 50 min from [C-11]methyl iodide in radiochemical purities > 99 %. The synthesis of 5-HTP is difficult due to its multi-enzymatic reaction steps but typical yields can be achieved of ca. 400 MBq. [C-11]-5-HTP is now reliably used in ongoing studies for staging NET. Copyright (c) 2006 John Wiley & Sons, Ltd.

AB - Precise staging of neuroendocrine tumors (NET) using positron emission tomography (PET) tracers visualizing their specific metabolic activity is of interest. Besides [F-18]FDOPA, staging NET with carbon-11 labeled 5-hydroxytryptophan (5-HTP) is reported in recent literature. We implemented the multi-enzymatic synthesis of enantiomerically pure [C-11]-L-5-HTP on a Zymark robotic system to compare both tracers in patient studies. [C-11]-5-HTP can be synthesized in up to 24% radiochemical yields (EOB). Average specific activity is 44000 GBq/mmol in ca. 50 min from [C-11]methyl iodide in radiochemical purities > 99 %. The synthesis of 5-HTP is difficult due to its multi-enzymatic reaction steps but typical yields can be achieved of ca. 400 MBq. [C-11]-5-HTP is now reliably used in ongoing studies for staging NET. Copyright (c) 2006 John Wiley & Sons, Ltd.

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CARCINOID-TUMORS

KW - L-TRYPTOPHAN

KW - 5-HYDROXY-L-TRYPTOPHAN

KW - ACIDS

U2 - 10.1002/jlcr.1110

DO - 10.1002/jlcr.1110

M3 - Article

VL - 49

SP - 889

EP - 895

JO - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

JF - JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

SN - 0362-4803

IS - 10

ER -

ID: 4483191