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Determining the Role of Dynamic Hyperinflation in Patients with Severe Chronic Obstructive Pulmonary Disease

Klooster, K., ten Hacken, N. H. T., Hartman, J. E., Sciurba, F. C., Kerstjens, H. A. M. & Slebos, D-J., 2015, In : Respiration. 90, 4, p. 306-313 8 p.

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  • Determining the Role of Dynamic Hyperinflation in Patients with Severe

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DOI

Background: Dynamic hyperinflation due to increased respiratory frequency during exercise is associated with limitations in exercise capacity in patients with moderately severe chronic obstructive pulmonary disease (COPD). Objectives: The present study assessed whether the manually paced tachypnea (MPT) test, sitting at rest, induces dynamic hyperinflation correlating with exercise capacity in patients with very severe COPD. Methods: Dynamic hyperinflation was induced by the MPT test, using a breathing frequency of 40/min for 1 min. Dynamic hyperinflation was defined as a 'change' in inspiratory capacity (IC) before and directly after the MPT test. At baseline, static hyperinflation by body plethysmography was measured, as well as the 6-min walking test and spirometry. Results: We studied 74 patients with severe COPD (age 59 +/- 9 years, FEV1 28 +/- 10% predicted). All patients tolerated the MPT test well. It induced a significant decrease in IC: -0.65 +/- 0.33 liters, p <0.001, correlating with the 6-min walking distance (rho = -0.246, p = 0.034). Static hyperinflation [IC/total lung capacity (TLC)] at baseline correlated stronger with the 6-min walking distance (r = 0.582, p <0.001). Multiple regression analysis showed that IC/TLC, but not dynamic hyperinflation, was the only independent predictor of walking distance. Conclusions: In patients with very severe COPD, dynamic hyperinflation measurement by the MPT test is feasible and contributes less importantly to exercise performance than static hyperinflation. (C) 2015 S. Karger AG, Basel

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalRespiration
Volume90
Issue number4
Early online date10-Sep-2015
Publication statusPublished - 2015

    Keywords

  • Chronic obstructive pulmonary disease, Dynamic hyperinflation, Static hyperinflation, Inspiratory capacity, Exercise capacity, METRONOME-PACED TACHYPNEA, FUNCTIONAL RESIDUAL CAPACITY, AIR-FLOW OBSTRUCTION, TOTAL LUNG CAPACITY, EXPIRATORY FLOW, EXERCISE, LIMITATION, DYSPNEA, COPD, VOLUME

ID: 28312553