Determining the Role of Dynamic Hyperinflation in Patients with Severe Chronic Obstructive Pulmonary DiseaseKlooster, K., ten Hacken, N. H. T., Hartman, J. E., Sciurba, F. C., Kerstjens, H. A. M. & Slebos, D-J., 2015, In : Respiration. 90, 4, p. 306-313 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
Background: Dynamic hyperinflation due to increased respiratory frequency during exercise is associated with limitations in exercise capacity in patients with moderately severe chronic obstructive pulmonary disease (COPD). Objectives: The present study assessed whether the manually paced tachypnea (MPT) test, sitting at rest, induces dynamic hyperinflation correlating with exercise capacity in patients with very severe COPD. Methods: Dynamic hyperinflation was induced by the MPT test, using a breathing frequency of 40/min for 1 min. Dynamic hyperinflation was defined as a 'change' in inspiratory capacity (IC) before and directly after the MPT test. At baseline, static hyperinflation by body plethysmography was measured, as well as the 6-min walking test and spirometry. Results: We studied 74 patients with severe COPD (age 59 +/- 9 years, FEV1 28 +/- 10% predicted). All patients tolerated the MPT test well. It induced a significant decrease in IC: -0.65 +/- 0.33 liters, p <0.001, correlating with the 6-min walking distance (rho = -0.246, p = 0.034). Static hyperinflation [IC/total lung capacity (TLC)] at baseline correlated stronger with the 6-min walking distance (r = 0.582, p <0.001). Multiple regression analysis showed that IC/TLC, but not dynamic hyperinflation, was the only independent predictor of walking distance. Conclusions: In patients with very severe COPD, dynamic hyperinflation measurement by the MPT test is feasible and contributes less importantly to exercise performance than static hyperinflation. (C) 2015 S. Karger AG, Basel
|Number of pages||8|
|Early online date||10-Sep-2015|
|Publication status||Published - 2015|
- Chronic obstructive pulmonary disease, Dynamic hyperinflation, Static hyperinflation, Inspiratory capacity, Exercise capacity, METRONOME-PACED TACHYPNEA, FUNCTIONAL RESIDUAL CAPACITY, AIR-FLOW OBSTRUCTION, TOTAL LUNG CAPACITY, EXPIRATORY FLOW, EXERCISE, LIMITATION, DYSPNEA, COPD, VOLUME