Determinants of adherence to inhaled corticosteroids in children with asthma

Klok, T., 2013, Groningen: s.n.. 144 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Teunis Klok
“The study described in this thesis was designed to identify determinants of longterm adherence to daily maintenance medication in children with asthma. Before this study was undertaken, there was a paucity on studies of long-term adherence in children with asthma, which is striking because asthma is a chronic disease which usually requires maintenance treatment taken for many years. Previous studies on adherence in children with asthma were also hampered by the lack of objective and reliable assessment of adherence. Most studies used self-report or pharmacy refill rates, both of which have been shown to be unreliable. Very few studies using electronic data loggers have been performed in children with asthma, and most of these studies used only short-term follow-up. When the study was designed, parental illness perceptions and medication beliefs were hypothesized to be the main determinant of long-term adherence in children with asthma. Therefore, these illness perceptions and medication beliefs were assessed comprehensively when patients were enrolled into the study, with a range of validated questionnaires designed for this purpose. Numerous other putative determinants of adherence were also assessed, along with a careful characterization of asthma control during follow-up. The study employed a mixed methods design, with both quantitative methods (measuring adherence electronically throughout 1-yr follow-up, and analysing the effects of various determinants on adherence measured in this way) and qualitative research methodology (focus group and individual interviews aimed at acquiring a rich and detailed description of parental views on the necessity of maintenance medication, their concerns about this treatment, and their strategies and behaviour regarding daily maintenance medication).
Original languageEnglish
QualificationDoctor of Philosophy
  • Brand, Paulus, Supervisor
  • Duiverman, Eric, Supervisor
  • Kaptein, A, Supervisor, External person
Award date12-Jun-2013
Place of PublicationGroningen
Publication statusPublished - 2013


  • Proefschriften (vorm), Huisartsen, Waarneming, Therapietrouw, Kinderen, Ouders, Astma, Inhalatie, Corticosteroïden, thorax

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