Publication

Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis

Hulshof, H. J., Novati, A., Luiten, P. G. M., den Boer, J. A. & Meerlo, P., 1-Oct-2012, In : Behavioral Brain Research. 234, 2, p. 357-364 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hulshof, H. J., Novati, A., Luiten, P. G. M., den Boer, J. A., & Meerlo, P. (2012). Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis. Behavioral Brain Research, 234(2), 357-364. https://doi.org/10.1016/j.bbr.2012.07.011

Author

Hulshof, Henriette J. ; Novati, Arianna ; Luiten, Paul G. M. ; den Boer, Johan A. ; Meerlo, Peter. / Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis. In: Behavioral Brain Research. 2012 ; Vol. 234, No. 2. pp. 357-364.

Harvard

Hulshof, HJ, Novati, A, Luiten, PGM, den Boer, JA & Meerlo, P 2012, 'Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis', Behavioral Brain Research, vol. 234, no. 2, pp. 357-364. https://doi.org/10.1016/j.bbr.2012.07.011

Standard

Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis. / Hulshof, Henriette J.; Novati, Arianna; Luiten, Paul G. M.; den Boer, Johan A.; Meerlo, Peter.

In: Behavioral Brain Research, Vol. 234, No. 2, 01.10.2012, p. 357-364.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hulshof HJ, Novati A, Luiten PGM, den Boer JA, Meerlo P. Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis. Behavioral Brain Research. 2012 Oct 1;234(2):357-364. https://doi.org/10.1016/j.bbr.2012.07.011


BibTeX

@article{3c0e7b7b3b7e4cf7a73964d257ecbeae,
title = "Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis",
abstract = "Sex differences in stress reactivity may be one of the factors underlying the increased sensitivity for the development of psychopathologies in women. Particularly, an increased hypothalamic-pituitary-adrenal (HPA) axis reactivity in females may exacerbate stress-induced changes in neuronal plasticity and neurogenesis, which in turn may contribute to an increased sensitivity to psychopathology. The main aim of the present study was to examine male-female differences in stress-induced changes in different aspects of hippocampal neurogenesis, i.e. cell proliferation, differentiation and survival. Both sexes were exposed to a wide variety of stressors, where after differences in HPA-axis reactivity and neurogenesis were assessed. To study the role of oestradiol in potential sex differences, ovariectomized females received low or high physiological oestradiol level replacement pellets. The results show that females in general have a higher basal and stress-induced HPA-axis activity than males, with minimal differences between the two female groups. Cell proliferation in the dorsal hippocampus was significantly higher in high oestradiol females compared to low oestradiol females and males, while doublecortin (DCX) expression as a marker of cell differentiation was significantly higher in males compared to females, independent of oestradiol level. Stress exposure did not significantly influence cell proliferation or survival of new cells, but did reduce DCX expression. In conclusion, despite the male-female differences in HPA-axis activity, the effect of repeated stress exposure on hippocampal cell differentiation was not significantly different between sexes. (C) 2012 Elsevier B.V. All rights reserved.",
keywords = "sex differences, gender differences, cycle, oestradiol, estradiol, ovariectomy, psychopathology, stress, stress sensitivity, hypothalamic-pituitary-adrenal axis, HPA axis, stress hormones, ACTH, corticosterone, glucocorticoids, neuronal plasticity, hippocampus, dentate gyrus, neurogenesis, cell proliferation, BrdU",
author = "Hulshof, {Henriette J.} and Arianna Novati and Luiten, {Paul G. M.} and {den Boer}, {Johan A.} and Peter Meerlo",
year = "2012",
month = "10",
day = "1",
doi = "10.1016/j.bbr.2012.07.011",
language = "English",
volume = "234",
pages = "357--364",
journal = "Behavioral Brain Research",
issn = "0166-4328",
publisher = "ELSEVIER SCIENCE BV",
number = "2",

}

RIS

TY - JOUR

T1 - Despite higher glucocorticoid levels and stress responses in female rats, both sexes exhibit similar stress-induced changes in hippocampal neurogenesis

AU - Hulshof, Henriette J.

AU - Novati, Arianna

AU - Luiten, Paul G. M.

AU - den Boer, Johan A.

AU - Meerlo, Peter

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Sex differences in stress reactivity may be one of the factors underlying the increased sensitivity for the development of psychopathologies in women. Particularly, an increased hypothalamic-pituitary-adrenal (HPA) axis reactivity in females may exacerbate stress-induced changes in neuronal plasticity and neurogenesis, which in turn may contribute to an increased sensitivity to psychopathology. The main aim of the present study was to examine male-female differences in stress-induced changes in different aspects of hippocampal neurogenesis, i.e. cell proliferation, differentiation and survival. Both sexes were exposed to a wide variety of stressors, where after differences in HPA-axis reactivity and neurogenesis were assessed. To study the role of oestradiol in potential sex differences, ovariectomized females received low or high physiological oestradiol level replacement pellets. The results show that females in general have a higher basal and stress-induced HPA-axis activity than males, with minimal differences between the two female groups. Cell proliferation in the dorsal hippocampus was significantly higher in high oestradiol females compared to low oestradiol females and males, while doublecortin (DCX) expression as a marker of cell differentiation was significantly higher in males compared to females, independent of oestradiol level. Stress exposure did not significantly influence cell proliferation or survival of new cells, but did reduce DCX expression. In conclusion, despite the male-female differences in HPA-axis activity, the effect of repeated stress exposure on hippocampal cell differentiation was not significantly different between sexes. (C) 2012 Elsevier B.V. All rights reserved.

AB - Sex differences in stress reactivity may be one of the factors underlying the increased sensitivity for the development of psychopathologies in women. Particularly, an increased hypothalamic-pituitary-adrenal (HPA) axis reactivity in females may exacerbate stress-induced changes in neuronal plasticity and neurogenesis, which in turn may contribute to an increased sensitivity to psychopathology. The main aim of the present study was to examine male-female differences in stress-induced changes in different aspects of hippocampal neurogenesis, i.e. cell proliferation, differentiation and survival. Both sexes were exposed to a wide variety of stressors, where after differences in HPA-axis reactivity and neurogenesis were assessed. To study the role of oestradiol in potential sex differences, ovariectomized females received low or high physiological oestradiol level replacement pellets. The results show that females in general have a higher basal and stress-induced HPA-axis activity than males, with minimal differences between the two female groups. Cell proliferation in the dorsal hippocampus was significantly higher in high oestradiol females compared to low oestradiol females and males, while doublecortin (DCX) expression as a marker of cell differentiation was significantly higher in males compared to females, independent of oestradiol level. Stress exposure did not significantly influence cell proliferation or survival of new cells, but did reduce DCX expression. In conclusion, despite the male-female differences in HPA-axis activity, the effect of repeated stress exposure on hippocampal cell differentiation was not significantly different between sexes. (C) 2012 Elsevier B.V. All rights reserved.

KW - sex differences

KW - gender differences

KW - cycle

KW - oestradiol

KW - estradiol

KW - ovariectomy

KW - psychopathology

KW - stress

KW - stress sensitivity

KW - hypothalamic-pituitary-adrenal axis

KW - HPA axis

KW - stress hormones

KW - ACTH

KW - corticosterone

KW - glucocorticoids

KW - neuronal plasticity

KW - hippocampus

KW - dentate gyrus

KW - neurogenesis

KW - cell proliferation

KW - BrdU

U2 - 10.1016/j.bbr.2012.07.011

DO - 10.1016/j.bbr.2012.07.011

M3 - Article

C2 - 22814114

VL - 234

SP - 357

EP - 364

JO - Behavioral Brain Research

JF - Behavioral Brain Research

SN - 0166-4328

IS - 2

ER -

ID: 5661435