Publication

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Deschasaux, M., Bouter, K. E., Prodan, A., Levin, E., Groen, A. K., Herrema, H., Tremaroli, V., Bakker, G. J., Attaye, I., Pinto-Sietsma, S-J., van Raalte, D. H., Snijder, M. B., Nicolaou, M., Peters, R., Zwinderman, A. H., Bäckhed, F. & Nieuwdorp, M., 27-Aug-2018, In : Nature Medicine. 11 p.

Research output: Contribution to journalLetterAcademicpeer-review

APA

Deschasaux, M., Bouter, K. E., Prodan, A., Levin, E., Groen, A. K., Herrema, H., ... Nieuwdorp, M. (2018). Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nature Medicine. https://doi.org/10.1038/s41591-018-0160-1

Author

Deschasaux, Mélanie ; Bouter, Kristien E ; Prodan, Andrei ; Levin, Evgeni ; Groen, Albert K ; Herrema, Hilde ; Tremaroli, Valentina ; Bakker, Guido J ; Attaye, Ilias ; Pinto-Sietsma, Sara-Joan ; van Raalte, Daniel H ; Snijder, Marieke B ; Nicolaou, Mary ; Peters, Ron ; Zwinderman, Aeilko H ; Bäckhed, Fredrik ; Nieuwdorp, Max. / Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. In: Nature Medicine. 2018.

Harvard

Deschasaux, M, Bouter, KE, Prodan, A, Levin, E, Groen, AK, Herrema, H, Tremaroli, V, Bakker, GJ, Attaye, I, Pinto-Sietsma, S-J, van Raalte, DH, Snijder, MB, Nicolaou, M, Peters, R, Zwinderman, AH, Bäckhed, F & Nieuwdorp, M 2018, 'Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography', Nature Medicine. https://doi.org/10.1038/s41591-018-0160-1

Standard

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. / Deschasaux, Mélanie; Bouter, Kristien E; Prodan, Andrei; Levin, Evgeni; Groen, Albert K; Herrema, Hilde; Tremaroli, Valentina; Bakker, Guido J; Attaye, Ilias; Pinto-Sietsma, Sara-Joan; van Raalte, Daniel H; Snijder, Marieke B; Nicolaou, Mary; Peters, Ron; Zwinderman, Aeilko H; Bäckhed, Fredrik; Nieuwdorp, Max.

In: Nature Medicine, 27.08.2018.

Research output: Contribution to journalLetterAcademicpeer-review

Vancouver

Deschasaux M, Bouter KE, Prodan A, Levin E, Groen AK, Herrema H et al. Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography. Nature Medicine. 2018 Aug 27. https://doi.org/10.1038/s41591-018-0160-1


BibTeX

@article{a654bf609ad94b36916b32f238ebe6ad,
title = "Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography",
abstract = "Trillions of microorganisms inhabit the human gut and are regarded as potential key factors for health1,2. Characteristics such as diet, lifestyle, or genetics can shape the composition of the gut microbiota2-6 and are usually shared by individuals from comparable ethnic origin. So far, most studies assessing how ethnicity relates to the intestinal microbiota compared small groups living at separate geographical locations7-10. Using fecal 16S ribosomal RNA gene sequencing in 2,084 participants of the Healthy Life in an Urban Setting (HELIUS) study11,12, we show that individuals living in the same city tend to share similar gut microbiota characteristics with others of their ethnic background. Ethnicity contributed to explain the interindividual dissimilarities in gut microbiota composition, with three main poles primarily characterized by operational taxonomic units (OTUs) classified as Prevotella (Moroccans, Turks, Ghanaians), Bacteroides (African Surinamese, South-Asian Surinamese), and Clostridiales (Dutch). The Dutch exhibited the greatest gut microbiota α-diversity and the South-Asian Surinamese the smallest, with corresponding enrichment or depletion in numerous OTUs. Ethnic differences in α-diversity and interindividual dissimilarities were independent of metabolic health and only partly explained by ethnic-related characteristics including sociodemographic, lifestyle, or diet factors. Hence, the ethnic origin of individuals may be an important factor to consider in microbiome research and its potential future applications in ethnic-diverse societies.",
author = "M{\'e}lanie Deschasaux and Bouter, {Kristien E} and Andrei Prodan and Evgeni Levin and Groen, {Albert K} and Hilde Herrema and Valentina Tremaroli and Bakker, {Guido J} and Ilias Attaye and Sara-Joan Pinto-Sietsma and {van Raalte}, {Daniel H} and Snijder, {Marieke B} and Mary Nicolaou and Ron Peters and Zwinderman, {Aeilko H} and Fredrik B{\"a}ckhed and Max Nieuwdorp",
year = "2018",
month = "8",
day = "27",
doi = "10.1038/s41591-018-0160-1",
language = "English",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

AU - Deschasaux, Mélanie

AU - Bouter, Kristien E

AU - Prodan, Andrei

AU - Levin, Evgeni

AU - Groen, Albert K

AU - Herrema, Hilde

AU - Tremaroli, Valentina

AU - Bakker, Guido J

AU - Attaye, Ilias

AU - Pinto-Sietsma, Sara-Joan

AU - van Raalte, Daniel H

AU - Snijder, Marieke B

AU - Nicolaou, Mary

AU - Peters, Ron

AU - Zwinderman, Aeilko H

AU - Bäckhed, Fredrik

AU - Nieuwdorp, Max

PY - 2018/8/27

Y1 - 2018/8/27

N2 - Trillions of microorganisms inhabit the human gut and are regarded as potential key factors for health1,2. Characteristics such as diet, lifestyle, or genetics can shape the composition of the gut microbiota2-6 and are usually shared by individuals from comparable ethnic origin. So far, most studies assessing how ethnicity relates to the intestinal microbiota compared small groups living at separate geographical locations7-10. Using fecal 16S ribosomal RNA gene sequencing in 2,084 participants of the Healthy Life in an Urban Setting (HELIUS) study11,12, we show that individuals living in the same city tend to share similar gut microbiota characteristics with others of their ethnic background. Ethnicity contributed to explain the interindividual dissimilarities in gut microbiota composition, with three main poles primarily characterized by operational taxonomic units (OTUs) classified as Prevotella (Moroccans, Turks, Ghanaians), Bacteroides (African Surinamese, South-Asian Surinamese), and Clostridiales (Dutch). The Dutch exhibited the greatest gut microbiota α-diversity and the South-Asian Surinamese the smallest, with corresponding enrichment or depletion in numerous OTUs. Ethnic differences in α-diversity and interindividual dissimilarities were independent of metabolic health and only partly explained by ethnic-related characteristics including sociodemographic, lifestyle, or diet factors. Hence, the ethnic origin of individuals may be an important factor to consider in microbiome research and its potential future applications in ethnic-diverse societies.

AB - Trillions of microorganisms inhabit the human gut and are regarded as potential key factors for health1,2. Characteristics such as diet, lifestyle, or genetics can shape the composition of the gut microbiota2-6 and are usually shared by individuals from comparable ethnic origin. So far, most studies assessing how ethnicity relates to the intestinal microbiota compared small groups living at separate geographical locations7-10. Using fecal 16S ribosomal RNA gene sequencing in 2,084 participants of the Healthy Life in an Urban Setting (HELIUS) study11,12, we show that individuals living in the same city tend to share similar gut microbiota characteristics with others of their ethnic background. Ethnicity contributed to explain the interindividual dissimilarities in gut microbiota composition, with three main poles primarily characterized by operational taxonomic units (OTUs) classified as Prevotella (Moroccans, Turks, Ghanaians), Bacteroides (African Surinamese, South-Asian Surinamese), and Clostridiales (Dutch). The Dutch exhibited the greatest gut microbiota α-diversity and the South-Asian Surinamese the smallest, with corresponding enrichment or depletion in numerous OTUs. Ethnic differences in α-diversity and interindividual dissimilarities were independent of metabolic health and only partly explained by ethnic-related characteristics including sociodemographic, lifestyle, or diet factors. Hence, the ethnic origin of individuals may be an important factor to consider in microbiome research and its potential future applications in ethnic-diverse societies.

U2 - 10.1038/s41591-018-0160-1

DO - 10.1038/s41591-018-0160-1

M3 - Letter

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

ER -

ID: 64523922