Publication

Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density: a Longitudinal PET Study

Parente, A., Scandiuzzi Maciel, E., J O Dierckx, R. A., Langendijk, J. A., de Vries, E. F. J. & Doorduin, J., 1-Sep-2020, In : International Journal of Radiation Biology. 96, 9, p. 1135-1143 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Parente, A., Scandiuzzi Maciel, E., J O Dierckx, R. A., Langendijk, J. A., de Vries, E. F. J., & Doorduin, J. (2020). Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density: a Longitudinal PET Study. International Journal of Radiation Biology, 96(9), 1135-1143. https://doi.org/10.1080/09553002.2020.1787542

Author

Parente, Andrea ; Scandiuzzi Maciel, Elisa ; J O Dierckx, Rudi A ; Langendijk, Johannes A ; de Vries, Erik F J ; Doorduin, Janine. / Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density : a Longitudinal PET Study. In: International Journal of Radiation Biology. 2020 ; Vol. 96, No. 9. pp. 1135-1143.

Harvard

Parente, A, Scandiuzzi Maciel, E, J O Dierckx, RA, Langendijk, JA, de Vries, EFJ & Doorduin, J 2020, 'Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density: a Longitudinal PET Study', International Journal of Radiation Biology, vol. 96, no. 9, pp. 1135-1143. https://doi.org/10.1080/09553002.2020.1787542

Standard

Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density : a Longitudinal PET Study. / Parente, Andrea; Scandiuzzi Maciel, Elisa; J O Dierckx, Rudi A; Langendijk, Johannes A; de Vries, Erik F J; Doorduin, Janine.

In: International Journal of Radiation Biology, Vol. 96, No. 9, 01.09.2020, p. 1135-1143.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Parente A, Scandiuzzi Maciel E, J O Dierckx RA, Langendijk JA, de Vries EFJ, Doorduin J. Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density: a Longitudinal PET Study. International Journal of Radiation Biology. 2020 Sep 1;96(9):1135-1143. https://doi.org/10.1080/09553002.2020.1787542


BibTeX

@article{1b939c3ea94244ef83e0075e820debc7,
title = "Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density: a Longitudinal PET Study",
abstract = "Purpose: Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and therefore new tools to investigate the processes leading to the delayed symptoms of brain irradiation are warranted. In this study, positron emission tomography (PET) is used to explore delayed functional changes induced by brain irradiation.Materials and Methods: Male Wistar rats were subjected to a single 25-Gy dose of whole brain X-ray irradiation, or sham-irradiation. To investigate delayed effects of radiation on cerebral glucose metabolism and myelin density, 18F-fluorodeoxyglucose (18F-FDG) PET scans were performed at baseline and on day 64 and 94, whereas N-11C methyl-4,4'-diaminostilbene (11C-MeDAS) PET scans were performed at baseline and on day 60 and 90 post-irradiation. In addition, the open field test (OFT) and novel spatial recognition test (NSR) were performed at baseline and on day 59 and 89 to investigate whether whole brain irradiation induces behavioral changes.Results: Whole brain irradiation caused loss of bodyweight and delayed cerebral hypometabolism, with 18F-FDG uptake in all brain regions being significantly decreased in irradiated rat on day 64 while it remained unchanged in control animals. Only amygdala and cortical brain regions of irradiated rats still showed reduced 18F-FDG uptake on day 94. 11C-MeDAS uptake in control animals was significantly lower on day 60 and 90 than at baseline, suggesting a reduction in myelin density in young adults. In irradiated animals, 11C-MeDAS uptake was similarly reduced on day 60, but on day 90 tracer uptake was somewhat increased and not significantly different from baseline anymore. Behavioral tests showed a similar pattern in control and irradiated animals. In both groups, the OFT showed significantly reduced mobility on day 59 and 89, whereas the NSR did not reveal any significant changes in spatial memory over time. Interestingly, a positive correlation between the NSR and 11C-MeDAS uptake was observed in irradiated rats.Conclusions: Whole-brain irradiation causes delayed brain hypometabolism, which is not accompanied by white matter loss. Irradiated animals showed similar behavioral changes over time as control animals and therefore cerebral hypometabolism could not be linked to behavioral abnormalities. However, spatial memory seems to be associated with myelin density in irradiated rats.",
author = "Andrea Parente and {Scandiuzzi Maciel}, Elisa and {J O Dierckx}, {Rudi A} and Langendijk, {Johannes A} and {de Vries}, {Erik F J} and Janine Doorduin",
year = "2020",
month = "9",
day = "1",
doi = "10.1080/09553002.2020.1787542",
language = "English",
volume = "96",
pages = "1135--1143",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
number = "9",

}

RIS

TY - JOUR

T1 - Delayed Effects of a Single Dose Whole-Brain Radiation Therapy on Glucose Metabolism and Myelin Density

T2 - a Longitudinal PET Study

AU - Parente, Andrea

AU - Scandiuzzi Maciel, Elisa

AU - J O Dierckx, Rudi A

AU - Langendijk, Johannes A

AU - de Vries, Erik F J

AU - Doorduin, Janine

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Purpose: Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and therefore new tools to investigate the processes leading to the delayed symptoms of brain irradiation are warranted. In this study, positron emission tomography (PET) is used to explore delayed functional changes induced by brain irradiation.Materials and Methods: Male Wistar rats were subjected to a single 25-Gy dose of whole brain X-ray irradiation, or sham-irradiation. To investigate delayed effects of radiation on cerebral glucose metabolism and myelin density, 18F-fluorodeoxyglucose (18F-FDG) PET scans were performed at baseline and on day 64 and 94, whereas N-11C methyl-4,4'-diaminostilbene (11C-MeDAS) PET scans were performed at baseline and on day 60 and 90 post-irradiation. In addition, the open field test (OFT) and novel spatial recognition test (NSR) were performed at baseline and on day 59 and 89 to investigate whether whole brain irradiation induces behavioral changes.Results: Whole brain irradiation caused loss of bodyweight and delayed cerebral hypometabolism, with 18F-FDG uptake in all brain regions being significantly decreased in irradiated rat on day 64 while it remained unchanged in control animals. Only amygdala and cortical brain regions of irradiated rats still showed reduced 18F-FDG uptake on day 94. 11C-MeDAS uptake in control animals was significantly lower on day 60 and 90 than at baseline, suggesting a reduction in myelin density in young adults. In irradiated animals, 11C-MeDAS uptake was similarly reduced on day 60, but on day 90 tracer uptake was somewhat increased and not significantly different from baseline anymore. Behavioral tests showed a similar pattern in control and irradiated animals. In both groups, the OFT showed significantly reduced mobility on day 59 and 89, whereas the NSR did not reveal any significant changes in spatial memory over time. Interestingly, a positive correlation between the NSR and 11C-MeDAS uptake was observed in irradiated rats.Conclusions: Whole-brain irradiation causes delayed brain hypometabolism, which is not accompanied by white matter loss. Irradiated animals showed similar behavioral changes over time as control animals and therefore cerebral hypometabolism could not be linked to behavioral abnormalities. However, spatial memory seems to be associated with myelin density in irradiated rats.

AB - Purpose: Radiotherapy is an important treatment option for brain tumors, but the unavoidable irradiation of normal brain tissue can lead to delayed cognitive impairment. The mechanisms involved are still not well explained and therefore new tools to investigate the processes leading to the delayed symptoms of brain irradiation are warranted. In this study, positron emission tomography (PET) is used to explore delayed functional changes induced by brain irradiation.Materials and Methods: Male Wistar rats were subjected to a single 25-Gy dose of whole brain X-ray irradiation, or sham-irradiation. To investigate delayed effects of radiation on cerebral glucose metabolism and myelin density, 18F-fluorodeoxyglucose (18F-FDG) PET scans were performed at baseline and on day 64 and 94, whereas N-11C methyl-4,4'-diaminostilbene (11C-MeDAS) PET scans were performed at baseline and on day 60 and 90 post-irradiation. In addition, the open field test (OFT) and novel spatial recognition test (NSR) were performed at baseline and on day 59 and 89 to investigate whether whole brain irradiation induces behavioral changes.Results: Whole brain irradiation caused loss of bodyweight and delayed cerebral hypometabolism, with 18F-FDG uptake in all brain regions being significantly decreased in irradiated rat on day 64 while it remained unchanged in control animals. Only amygdala and cortical brain regions of irradiated rats still showed reduced 18F-FDG uptake on day 94. 11C-MeDAS uptake in control animals was significantly lower on day 60 and 90 than at baseline, suggesting a reduction in myelin density in young adults. In irradiated animals, 11C-MeDAS uptake was similarly reduced on day 60, but on day 90 tracer uptake was somewhat increased and not significantly different from baseline anymore. Behavioral tests showed a similar pattern in control and irradiated animals. In both groups, the OFT showed significantly reduced mobility on day 59 and 89, whereas the NSR did not reveal any significant changes in spatial memory over time. Interestingly, a positive correlation between the NSR and 11C-MeDAS uptake was observed in irradiated rats.Conclusions: Whole-brain irradiation causes delayed brain hypometabolism, which is not accompanied by white matter loss. Irradiated animals showed similar behavioral changes over time as control animals and therefore cerebral hypometabolism could not be linked to behavioral abnormalities. However, spatial memory seems to be associated with myelin density in irradiated rats.

U2 - 10.1080/09553002.2020.1787542

DO - 10.1080/09553002.2020.1787542

M3 - Article

C2 - 32602390

VL - 96

SP - 1135

EP - 1143

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 9

ER -

ID: 128740489