Publication

Defining and Measuring the Affordability of New Medicines: A Systematic Review

Antonanzas, F., Terkola, R., Overton, P. M., Shalet, N. & Postma, M., Aug-2017, In : Pharmacoeconomics. 35, 8, p. 777-791 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Antonanzas, F., Terkola, R., Overton, P. M., Shalet, N., & Postma, M. (2017). Defining and Measuring the Affordability of New Medicines: A Systematic Review. Pharmacoeconomics, 35(8), 777-791. https://doi.org/10.1007/s40273-017-0514-4

Author

Antonanzas, Fernando ; Terkola, Robert ; Overton, Paul M. ; Shalet, Natalie ; Postma, Maarten. / Defining and Measuring the Affordability of New Medicines : A Systematic Review. In: Pharmacoeconomics. 2017 ; Vol. 35, No. 8. pp. 777-791.

Harvard

Antonanzas, F, Terkola, R, Overton, PM, Shalet, N & Postma, M 2017, 'Defining and Measuring the Affordability of New Medicines: A Systematic Review', Pharmacoeconomics, vol. 35, no. 8, pp. 777-791. https://doi.org/10.1007/s40273-017-0514-4

Standard

Defining and Measuring the Affordability of New Medicines : A Systematic Review. / Antonanzas, Fernando; Terkola, Robert; Overton, Paul M.; Shalet, Natalie; Postma, Maarten.

In: Pharmacoeconomics, Vol. 35, No. 8, 08.2017, p. 777-791.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Antonanzas F, Terkola R, Overton PM, Shalet N, Postma M. Defining and Measuring the Affordability of New Medicines: A Systematic Review. Pharmacoeconomics. 2017 Aug;35(8):777-791. https://doi.org/10.1007/s40273-017-0514-4


BibTeX

@article{db4da17e6cff494185c959abbe7488cb,
title = "Defining and Measuring the Affordability of New Medicines: A Systematic Review",
abstract = "Background In many healthcare systems, affordability concerns can lead to restrictions on the use of expensive efficacious therapies. However, there does not appear to be any consensus as to the terminology used to describe affordability, or the thresholds used to determine whether new drugs are affordable.Objectives The aim of this systematic review was to investigate how affordability is defined and measured in healthcare.Methods MEDLINE, EMBASE and EconLit databases (2005-July 2016) were searched using terms covering affordability and budget impact, combined with definitions, thresholds and restrictions, to identify articles describing a definition of affordability with respect to new medicines. Additional definitions were identified through citation searching, and through manual searches of European health technology assessment body websites.Results In total, 27 definitions were included in the review. Of these, five definitions described affordability in terms of the value of a product; seven considered affordability within the context of healthcare system budgets; and 15 addressed whether products are affordable in a given country based on economic factors. However, there was little in the literature to indicate that the price of medicines is considered alongside both their value to individual patients and their budget impact at a population level.Conclusions Current methods of assessing affordability in healthcare may be limited by their focus on budget impact. A more effective approach may involve a broader perspective than is currently described in the literature, to consider the long-term benefits of a therapy and cost savings elsewhere in the healthcare system, as well as cooperation between healthcare payers and the pharmaceutical industry to develop financing models that support sustainability as well as innovation.",
keywords = "HEALTH-CARE, COST-EFFECTIVENESS, UNITED-STATES, CANCER DRUGS, PERSONALIZED MEDICINE, NATIONAL INSTITUTE, PATIENT ACCESS, COUNTRIES, AVAILABILITY, BUDGET",
author = "Fernando Antonanzas and Robert Terkola and Overton, {Paul M.} and Natalie Shalet and Maarten Postma",
year = "2017",
month = "8",
doi = "10.1007/s40273-017-0514-4",
language = "English",
volume = "35",
pages = "777--791",
journal = "Pharmacoeconomics",
issn = "1170-7690",
publisher = "ADIS INT LTD",
number = "8",

}

RIS

TY - JOUR

T1 - Defining and Measuring the Affordability of New Medicines

T2 - A Systematic Review

AU - Antonanzas, Fernando

AU - Terkola, Robert

AU - Overton, Paul M.

AU - Shalet, Natalie

AU - Postma, Maarten

PY - 2017/8

Y1 - 2017/8

N2 - Background In many healthcare systems, affordability concerns can lead to restrictions on the use of expensive efficacious therapies. However, there does not appear to be any consensus as to the terminology used to describe affordability, or the thresholds used to determine whether new drugs are affordable.Objectives The aim of this systematic review was to investigate how affordability is defined and measured in healthcare.Methods MEDLINE, EMBASE and EconLit databases (2005-July 2016) were searched using terms covering affordability and budget impact, combined with definitions, thresholds and restrictions, to identify articles describing a definition of affordability with respect to new medicines. Additional definitions were identified through citation searching, and through manual searches of European health technology assessment body websites.Results In total, 27 definitions were included in the review. Of these, five definitions described affordability in terms of the value of a product; seven considered affordability within the context of healthcare system budgets; and 15 addressed whether products are affordable in a given country based on economic factors. However, there was little in the literature to indicate that the price of medicines is considered alongside both their value to individual patients and their budget impact at a population level.Conclusions Current methods of assessing affordability in healthcare may be limited by their focus on budget impact. A more effective approach may involve a broader perspective than is currently described in the literature, to consider the long-term benefits of a therapy and cost savings elsewhere in the healthcare system, as well as cooperation between healthcare payers and the pharmaceutical industry to develop financing models that support sustainability as well as innovation.

AB - Background In many healthcare systems, affordability concerns can lead to restrictions on the use of expensive efficacious therapies. However, there does not appear to be any consensus as to the terminology used to describe affordability, or the thresholds used to determine whether new drugs are affordable.Objectives The aim of this systematic review was to investigate how affordability is defined and measured in healthcare.Methods MEDLINE, EMBASE and EconLit databases (2005-July 2016) were searched using terms covering affordability and budget impact, combined with definitions, thresholds and restrictions, to identify articles describing a definition of affordability with respect to new medicines. Additional definitions were identified through citation searching, and through manual searches of European health technology assessment body websites.Results In total, 27 definitions were included in the review. Of these, five definitions described affordability in terms of the value of a product; seven considered affordability within the context of healthcare system budgets; and 15 addressed whether products are affordable in a given country based on economic factors. However, there was little in the literature to indicate that the price of medicines is considered alongside both their value to individual patients and their budget impact at a population level.Conclusions Current methods of assessing affordability in healthcare may be limited by their focus on budget impact. A more effective approach may involve a broader perspective than is currently described in the literature, to consider the long-term benefits of a therapy and cost savings elsewhere in the healthcare system, as well as cooperation between healthcare payers and the pharmaceutical industry to develop financing models that support sustainability as well as innovation.

KW - HEALTH-CARE

KW - COST-EFFECTIVENESS

KW - UNITED-STATES

KW - CANCER DRUGS

KW - PERSONALIZED MEDICINE

KW - NATIONAL INSTITUTE

KW - PATIENT ACCESS

KW - COUNTRIES

KW - AVAILABILITY

KW - BUDGET

U2 - 10.1007/s40273-017-0514-4

DO - 10.1007/s40273-017-0514-4

M3 - Review article

C2 - 28477220

VL - 35

SP - 777

EP - 791

JO - Pharmacoeconomics

JF - Pharmacoeconomics

SN - 1170-7690

IS - 8

ER -

ID: 47102602