Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogueFiebrich, H. -B., van den Berg, G., Kema, I. P., Links, T. P., Kleibeuker, J. H., van Beek, A. P., Walenkamp, A. M. E., Sluiter, W. J. & de Vries, E. G. E., 1-Dec-2010, In : Alimentary Pharmacology & Therapeutics. 32, 11-12, p. 1398-1404 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels remains unknown.
To investigate the prevalence of fat-soluble vitamin deficiencies in long-term somatostatin analogue users.
All acromegaly and carcinoid patients using somatostatin analogues for >= 18 months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat-soluble vitamins in blood, clinical and vitamin-dependent laboratory parameters were collected.
In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty-two (78%) were deficient for one or more vitamins, and 32% (n = 17) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels.
Fat-soluble vitamin deficiencies are frequent during long-term somatostatin analogue treatment. Therefore, fat-soluble vitamins should be monitored in these patients.
|Number of pages||7|
|Journal||Alimentary Pharmacology & Therapeutics|
|Publication status||Published - 1-Dec-2010|
- NEUROENDOCRINE TUMORS, CHRONIC OCTREOTIDE, ALPHA-TOCOPHEROL, HUMAN-PLASMA, MANAGEMENT, GUIDELINES, ABSORPTION, RESECTION, CAROTENOIDS, LYMPHOCYTES