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Decreased plasma levels of activated factor VII in patients with deep vein thrombosis

Schut, A. M., Meijers, J. C. M., Lisman-van Leeuwen, Y., van Montfoort, M. L., Roest, M., de Groot, P. G., Urbanus, R. T., Coppens, M. & Lisman, T., Jul-2015, In : JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 13, 7, p. 1320-1324 5 p.

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BackgroundThe initiating trigger in the development of deep vein thrombosis (DVT) remains unidentified. It has been suggested that tissue factor (TF)-bearing microparticles play a key role, which indicates a role for the TF pathway in the initiation of DVT.

ObjectiveTo assess the role of the TF pathway in the initiation of venous thrombosis, we measured plasma levels of factor VII and VIIa in patients with acute DVT and in controls.

MethodsWe included 148 patients diagnosed with acute DVT and 179 controls in this study. Antigen levels of FVII and FVIIa were measured by using assays recently developed in our laboratory.

ResultsMedian FVII levels in patients were 109.8% (interquartile range [IQR] 86.0-153.2) compared with 102.2% (IQR 76.1-141.7) in controls. Individuals with FVII levels in the upper quartile had a 1.6-fold increased risk for the presence of a DVT (odds ratio 1.6, 95% confidence interval 0.8-3.1). Median FVIIa levels in patients were 50.2ngmL(-1) (IQR 25.2-86.1) compared with 96.6ngmL(-1) (69.9-168.9) in controls. Individuals with FVIIa levels in the lowest quartile had a > 5-fold increased risk for the presence of a DVT (odds ratio 5.5, 95% confidence interval 2.8-10.6). Both risks did not change substantially after adjustment for potential confounders.

ConclusionDecreased plasma levels of FVIIa in patients with deep vein thrombosis may indicate ongoing consumption of FVIIa and suggest a contributory role for TF in venous thrombus formation.

Original languageEnglish
Pages (from-to)1320-1324
Number of pages5
JournalJOURNAL OF THROMBOSIS AND HAEMOSTASIS
Volume13
Issue number7
Publication statusPublished - Jul-2015

    Keywords

  • blood coagulation, factor VII, factor VIIa, tissue factor, venous thrombosis, PROTHROMBIN FRAGMENT 1+2, VENOUS THROMBOSIS, TISSUE FACTOR, LEIDEN THROMBOPHILIA, RISK-FACTOR, FACTOR-XI, COAGULATION, COMPLEXES, PATHWAY, DISEASE

ID: 20744614