Publication

Decreased placental glypican expression is associated with human fetal growth restriction

Gunatillake, T., Chui, A., Fitzpatrick, E., Ignjatovic, V., Monagle, P., Whitelock, J., Zanten, D., Eijsink, J., Borg, A., Stevenson, J., Brennecke, S. P., Erwich, J. J. H. M., Said, J. M. & Murthi, P., 15-Jan-2019, In : Placenta. 76, p. 6-9 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Gunatillake, T., Chui, A., Fitzpatrick, E., Ignjatovic, V., Monagle, P., Whitelock, J., ... Murthi, P. (2019). Decreased placental glypican expression is associated with human fetal growth restriction. Placenta, 76, 6-9. https://doi.org/10.1016/j.placenta.2018.12.007

Author

Gunatillake, T. ; Chui, A. ; Fitzpatrick, E. ; Ignjatovic, V. ; Monagle, P. ; Whitelock, J. ; Zanten, D. ; Eijsink, J. ; Borg, A. ; Stevenson, J. ; Brennecke, S. P. ; Erwich, J. J. H. M. ; Said, J. M. ; Murthi, P. / Decreased placental glypican expression is associated with human fetal growth restriction. In: Placenta. 2019 ; Vol. 76. pp. 6-9.

Harvard

Gunatillake, T, Chui, A, Fitzpatrick, E, Ignjatovic, V, Monagle, P, Whitelock, J, Zanten, D, Eijsink, J, Borg, A, Stevenson, J, Brennecke, SP, Erwich, JJHM, Said, JM & Murthi, P 2019, 'Decreased placental glypican expression is associated with human fetal growth restriction', Placenta, vol. 76, pp. 6-9. https://doi.org/10.1016/j.placenta.2018.12.007

Standard

Decreased placental glypican expression is associated with human fetal growth restriction. / Gunatillake, T.; Chui, A.; Fitzpatrick, E.; Ignjatovic, V.; Monagle, P.; Whitelock, J.; Zanten, D.; Eijsink, J.; Borg, A.; Stevenson, J.; Brennecke, S. P.; Erwich, J. J. H. M.; Said, J. M.; Murthi, P.

In: Placenta, Vol. 76, 15.01.2019, p. 6-9.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Gunatillake T, Chui A, Fitzpatrick E, Ignjatovic V, Monagle P, Whitelock J et al. Decreased placental glypican expression is associated with human fetal growth restriction. Placenta. 2019 Jan 15;76:6-9. https://doi.org/10.1016/j.placenta.2018.12.007


BibTeX

@article{7d2892c702174d3195a4abac3eb1abb0,
title = "Decreased placental glypican expression is associated with human fetal growth restriction",
abstract = "Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteoglycans (HSPG) are highly expressed in placentae and regulate haemostasis. We hypothesise that altered expression of HSPGs, glypicans (GPC) may contribute to the development of FGR and small-for-gestational-age (SGA). GPC expression was determined in first-trimester chorionic villous samples collected from women with later SGA pregnancies and in placentae from third-trimester FGR and gestation-matched uncomplicated pregnancies. The expression of both GPC1 and GPC3 were significantly reduced in first-trimester SGA as well as in the third-trimester FGR placentae compared to controls. This is the first study to report a relationship between altered placental GPC expression and subsequent development of SGA/FGR.",
keywords = "Proteoglycans, Heparan sulphate, Glypican, Fetal growth, Restriction, CELLS, SULFATE",
author = "T. Gunatillake and A. Chui and E. Fitzpatrick and V. Ignjatovic and P. Monagle and J. Whitelock and D. Zanten and J. Eijsink and A. Borg and J. Stevenson and Brennecke, {S. P.} and Erwich, {J. J. H. M.} and Said, {J. M.} and P. Murthi",
year = "2019",
month = "1",
day = "15",
doi = "10.1016/j.placenta.2018.12.007",
language = "English",
volume = "76",
pages = "6--9",
journal = "Placenta",
issn = "0143-4004",
publisher = "W B SAUNDERS CO LTD",

}

RIS

TY - JOUR

T1 - Decreased placental glypican expression is associated with human fetal growth restriction

AU - Gunatillake, T.

AU - Chui, A.

AU - Fitzpatrick, E.

AU - Ignjatovic, V.

AU - Monagle, P.

AU - Whitelock, J.

AU - Zanten, D.

AU - Eijsink, J.

AU - Borg, A.

AU - Stevenson, J.

AU - Brennecke, S. P.

AU - Erwich, J. J. H. M.

AU - Said, J. M.

AU - Murthi, P.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteoglycans (HSPG) are highly expressed in placentae and regulate haemostasis. We hypothesise that altered expression of HSPGs, glypicans (GPC) may contribute to the development of FGR and small-for-gestational-age (SGA). GPC expression was determined in first-trimester chorionic villous samples collected from women with later SGA pregnancies and in placentae from third-trimester FGR and gestation-matched uncomplicated pregnancies. The expression of both GPC1 and GPC3 were significantly reduced in first-trimester SGA as well as in the third-trimester FGR placentae compared to controls. This is the first study to report a relationship between altered placental GPC expression and subsequent development of SGA/FGR.

AB - Placental mediated fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Heparan sulphate proteoglycans (HSPG) are highly expressed in placentae and regulate haemostasis. We hypothesise that altered expression of HSPGs, glypicans (GPC) may contribute to the development of FGR and small-for-gestational-age (SGA). GPC expression was determined in first-trimester chorionic villous samples collected from women with later SGA pregnancies and in placentae from third-trimester FGR and gestation-matched uncomplicated pregnancies. The expression of both GPC1 and GPC3 were significantly reduced in first-trimester SGA as well as in the third-trimester FGR placentae compared to controls. This is the first study to report a relationship between altered placental GPC expression and subsequent development of SGA/FGR.

KW - Proteoglycans

KW - Heparan sulphate

KW - Glypican

KW - Fetal growth

KW - Restriction

KW - CELLS

KW - SULFATE

U2 - 10.1016/j.placenta.2018.12.007

DO - 10.1016/j.placenta.2018.12.007

M3 - Article

VL - 76

SP - 6

EP - 9

JO - Placenta

JF - Placenta

SN - 0143-4004

ER -

ID: 91984273