Publication

Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect

Cappel, WHDTN., Buskens, E., van Duijvendijk, P., Cats, A., Menko, FH., Griffioen, G., Slors, JF., Nagengast, FM., Kleibeuker, JH. & Vasen, HFA., 1-Dec-2003, In : Gut. 52, 12, p. 1752-1755 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Cappel, WHDTN., Buskens, E., van Duijvendijk, P., Cats, A., Menko, FH., Griffioen, G., ... Vasen, HFA. (2003). Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. Gut, 52(12), 1752-1755.

Author

Cappel, WHDTN ; Buskens, E ; van Duijvendijk, P ; Cats, A ; Menko, FH ; Griffioen, G ; Slors, JF ; Nagengast, FM ; Kleibeuker, JH ; Vasen, HFA. / Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. In: Gut. 2003 ; Vol. 52, No. 12. pp. 1752-1755.

Harvard

Cappel, WHDTN, Buskens, E, van Duijvendijk, P, Cats, A, Menko, FH, Griffioen, G, Slors, JF, Nagengast, FM, Kleibeuker, JH & Vasen, HFA 2003, 'Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect', Gut, vol. 52, no. 12, pp. 1752-1755.

Standard

Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. / Cappel, WHDTN; Buskens, E; van Duijvendijk, P; Cats, A; Menko, FH; Griffioen, G; Slors, JF; Nagengast, FM; Kleibeuker, JH; Vasen, HFA.

In: Gut, Vol. 52, No. 12, 01.12.2003, p. 1752-1755.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Cappel WHDTN, Buskens E, van Duijvendijk P, Cats A, Menko FH, Griffioen G et al. Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect. Gut. 2003 Dec 1;52(12):1752-1755.


BibTeX

@article{97ee2cf8d8fb4f5f9a131d676d1e10df,
title = "Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect",
abstract = "Background: In view of the high risk of developing a new primary colorectal carcinoma (CRC), subtotal colectomy rather than segmental resection or hemicolectomy is the preferred treatment in hereditary nonpolyposis colorectal cancer (HNPCC) patients. Subtotal colectomy however implies a substantial decrease in quality of life. To date, colonoscopic surveillance has been shown to reduce CRC occurrence.Aims: To compare the potential health effects in terms of life expectancy ( LE) for patients undergoing subtotal colectomy or hemicolectomy for CRC.Methods: A decision analysis ( Markov) model was created. Information on the 10 year risk of CRC after subtotal colectomy (4{\%}) and hemicolectomy (16{\%}) and stages of CRCs detected within a two year surveillance interval (32{\%} Dukes' A, 54{\%} Dukes' B, and 14{\%} Dukes' C) were derived from two cohort studies. Five year survival rates used for the different Dukes stages ( A, B, and C) were 98{\%}, 80{\%}, and 60{\%}, respectively. Remaining LE values were calculated for hypothetical cohorts with an age at CRC diagnosis of 27, 47, and 67 years, respectively. Remaining LE values were also calculated for patients with CRC of Dukes' stage A.Results: The overall LE gain of subtotal colectomy compared with hemicolectomy at ages 27, 47, and 67 was 2.3, 1, and 0.3 years, respectively. Specifically for Dukes' stage A, this would be 3.4, 1.5, and 0.4 years.Conclusions: Unless surveillance results improve, subtotal colectomy still seems the preferred treatment for CRC in HNPCC in view of the difference in LE. For older patients, hemicolectomy may be an option as there is no appreciable difference in LE.",
keywords = "FAMILIAL ADENOMATOUS POLYPOSIS, ILEORECTAL ANASTOMOSIS, MUTATION CARRIERS, COLECTOMY, CARCINOMA, RISK, SURVIVAL, TRIAL, PROCTOCOLECTOMY, SURVEILLANCE",
author = "WHDTN Cappel and E Buskens and {van Duijvendijk}, P and A Cats and FH Menko and G Griffioen and JF Slors and FM Nagengast and JH Kleibeuker and HFA Vasen",
year = "2003",
month = "12",
day = "1",
language = "English",
volume = "52",
pages = "1752--1755",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Decision analysis in the surgical treatment of colorectal cancer due to a mismatch repair gene defect

AU - Cappel, WHDTN

AU - Buskens, E

AU - van Duijvendijk, P

AU - Cats, A

AU - Menko, FH

AU - Griffioen, G

AU - Slors, JF

AU - Nagengast, FM

AU - Kleibeuker, JH

AU - Vasen, HFA

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Background: In view of the high risk of developing a new primary colorectal carcinoma (CRC), subtotal colectomy rather than segmental resection or hemicolectomy is the preferred treatment in hereditary nonpolyposis colorectal cancer (HNPCC) patients. Subtotal colectomy however implies a substantial decrease in quality of life. To date, colonoscopic surveillance has been shown to reduce CRC occurrence.Aims: To compare the potential health effects in terms of life expectancy ( LE) for patients undergoing subtotal colectomy or hemicolectomy for CRC.Methods: A decision analysis ( Markov) model was created. Information on the 10 year risk of CRC after subtotal colectomy (4%) and hemicolectomy (16%) and stages of CRCs detected within a two year surveillance interval (32% Dukes' A, 54% Dukes' B, and 14% Dukes' C) were derived from two cohort studies. Five year survival rates used for the different Dukes stages ( A, B, and C) were 98%, 80%, and 60%, respectively. Remaining LE values were calculated for hypothetical cohorts with an age at CRC diagnosis of 27, 47, and 67 years, respectively. Remaining LE values were also calculated for patients with CRC of Dukes' stage A.Results: The overall LE gain of subtotal colectomy compared with hemicolectomy at ages 27, 47, and 67 was 2.3, 1, and 0.3 years, respectively. Specifically for Dukes' stage A, this would be 3.4, 1.5, and 0.4 years.Conclusions: Unless surveillance results improve, subtotal colectomy still seems the preferred treatment for CRC in HNPCC in view of the difference in LE. For older patients, hemicolectomy may be an option as there is no appreciable difference in LE.

AB - Background: In view of the high risk of developing a new primary colorectal carcinoma (CRC), subtotal colectomy rather than segmental resection or hemicolectomy is the preferred treatment in hereditary nonpolyposis colorectal cancer (HNPCC) patients. Subtotal colectomy however implies a substantial decrease in quality of life. To date, colonoscopic surveillance has been shown to reduce CRC occurrence.Aims: To compare the potential health effects in terms of life expectancy ( LE) for patients undergoing subtotal colectomy or hemicolectomy for CRC.Methods: A decision analysis ( Markov) model was created. Information on the 10 year risk of CRC after subtotal colectomy (4%) and hemicolectomy (16%) and stages of CRCs detected within a two year surveillance interval (32% Dukes' A, 54% Dukes' B, and 14% Dukes' C) were derived from two cohort studies. Five year survival rates used for the different Dukes stages ( A, B, and C) were 98%, 80%, and 60%, respectively. Remaining LE values were calculated for hypothetical cohorts with an age at CRC diagnosis of 27, 47, and 67 years, respectively. Remaining LE values were also calculated for patients with CRC of Dukes' stage A.Results: The overall LE gain of subtotal colectomy compared with hemicolectomy at ages 27, 47, and 67 was 2.3, 1, and 0.3 years, respectively. Specifically for Dukes' stage A, this would be 3.4, 1.5, and 0.4 years.Conclusions: Unless surveillance results improve, subtotal colectomy still seems the preferred treatment for CRC in HNPCC in view of the difference in LE. For older patients, hemicolectomy may be an option as there is no appreciable difference in LE.

KW - FAMILIAL ADENOMATOUS POLYPOSIS

KW - ILEORECTAL ANASTOMOSIS

KW - MUTATION CARRIERS

KW - COLECTOMY

KW - CARCINOMA

KW - RISK

KW - SURVIVAL

KW - TRIAL

KW - PROCTOCOLECTOMY

KW - SURVEILLANCE

M3 - Article

VL - 52

SP - 1752

EP - 1755

JO - Gut

JF - Gut

SN - 0017-5749

IS - 12

ER -

ID: 4148042