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De associatie tussen HTR2C-polymorfismen en de prevalentie van het metabool syndroom bij patiënten die antipsychotica gebruiken: Een replicatiestudie

Risselad, A. J., Veho, J., Bruggeman, R., Wilffert, B., Cohen, D., Al Hadithy, A. F., Arends, J. & Mulder, H., 16-Nov-2012, In : Pharmaceutisch Weekblad. 147, 46, p. 190-194 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

OBJECTIVE: In two previous studies we found an association between HTR2C polymorphisms and the prevalence of the metabolic syndrome in patients using antipsychotics. In this study, we set out to replicate our findings in a third separate sample of patients. DESIGN AND METHODS: Data for this cross-sectional study came from the ongoing Pharmacotherapy Monitoring and Outcome survey study, investigating the association between schizophrenia and metabolic or cardiovascular risk factors. Primary end point was the prevalence of the metabolic syndrome. Primary determinants were two polymorphisms in the HTR2C gene: rs3813929 (759 C/T) and rs1414334:C>G. RESULTS: Carriership of the variant rs1414334 C allele was significantly associated with an increased prevalence of the metabolic syndrome (odds ratio 3.73; 95% confidence interval 1.29-10.79; P = 0.015). No association was found between the HTR2C 759 C/T polymorphism and the metabolic syndrome. CONCLUSION: This study confirms previous findings that the variant C-allele of the rs1414334 polymorphism is associated with the metabolic syndrome.
Translated title of the contributionAssociation between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: A replication study
Original languageDutch
Pages (from-to)190-194
Number of pages5
JournalPharmaceutisch Weekblad
Volume147
Issue number46
Publication statusPublished - 16-Nov-2012

    Keywords

  • cysteine, htr2c protein, membrane protein, neuroleptic agent, threonine, unclassified drug, allele, article, cardiovascular risk, cross-sectional study, genetic association, genetic polymorphism, genetic variability, human, metabolic syndrome X, schizophrenia

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