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Data-Driven Prioritization and Review of Targets for Molecular-Based Theranostic Approaches in Pancreatic Cancer

Koller, M., Hartmans, E., de Groot, D. J. A., Zhao, X. J., van Dam, G. M., Nagengast, W. B. & Fehrmann, R. S. N., 1-Dec-2017, In : Journal of Nuclear Medicine. 58, 12, p. 1899-1903 5 p.

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  • Data-Driven Prioritization and Review of Targets for Molecular-Based Theranostic Approaches in Pancreatic Cancer

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DOI

Molecularly targeted therapeutic and imaging strategies directed at aberrant signaling pathways in pancreatic tumor cells may improve the poor outcome of pancreatic ductal adenocarcinoma (PDA). Therefore, relevant molecular targets need to be identified. 

Methods: We collected publicly available expression profiles of patient-derived normal pancreatic tissue (n = 77) and PDA samples (n = 103). Functional genomic messenger RNA profiling was applied to predict target upregulation on the protein level. We prioritized these targets based on current status of preclinical therapeutic and imaging evaluation in PDA. 

Results: We identified 213 significantly upregulated proteins in PDA compared with normal pancreatic tissue. We prioritized mucin-1, mesothelin, g-glutamyltransferase 5, and cathepsin-E as the most interesting targets, because studies already demonstrated their potential for both therapeutic and imaging strategies in literature. 

Conclusion: This study can assist clinicians and drug developers in deciding which theranostic targets should be taken for further clinical evaluation in PDA.

Original languageEnglish
Pages (from-to)1899-1903
Number of pages5
JournalJournal of Nuclear Medicine
Volume58
Issue number12
Publication statusPublished - 1-Dec-2017

    Keywords

  • pancreatic ductal adenocarcinoma (PDA), pancreatic cancer, theranostic approach, targeted molecular therapy, targeted molecular imaging, genetic profiling, biomarker, OVARIAN-CANCER, CATHEPSIN-E, MESOTHELIN, ADENOCARCINOMAS, IDENTIFICATION, GEMCITABINE, ANTIBODY, PROBE, MICE

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