Publication

D-2-like receptor stimulation decreases effective renal plasma flow and glomerular filtration rate in spontaneously hypertensive rats

de Vries, PAM., de Jong, PE., de Zeeuw, D. & Navis, GJ., Jul-2002, In : Journal of Cardiovascular Pharmacology. 40, 1, p. 35-42 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

In spontaneously hypertensive rats (SHRs) the dopaminergic D-1-like renal vasodilator response is impaired. The renal vascular response to D-2-like receptor stimulation in vivo is incompletely known. Therefore, renal hemodynamics were studied in conscious SHRs during continuous infusion of D-2-like agonist N,N-Di-n-propyldopamine (DPDA) (10 mug/kg/min) with Wistar-Kyoto (WKY) rats as controls. As sodium status may affect dopaminergic responses, rats were studied during both low- and high-sodium diets. D-2-like stimulation reduced mean arterial pressure and effective renal plasma flow and glomerular filtration rate (GFR) similarly in SHR and WKY rats. Renal vascular resistance increased significantly in both strains. The response to DPDA is modified by sodium status, with a more pronounced fall in blood pressure (in WKYs and SHRs) and GFR (in WKYs) during high-sodium conditions. The responses were blocked by co-infusion with D-2 antagonist domperidone. Thus, D-2-like renal vascular responses are normal in SHRs irrespective of sodium intake. The combination of a preserved D-2-like renal vasoconstrictive and an impaired D-1-like renal vasodilatory response may contribute to maintenance of hypertension in SHRs.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalJournal of Cardiovascular Pharmacology
Volume40
Issue number1
Publication statusPublished - Jul-2002

    Keywords

  • blood pressure, D-2-like receptor agonist, dopamine, renal function, spontaneously hypertensive rats, DOPAMINE-RECEPTORS, KIDNEY, AGONIST, ACTIVATION, EXPRESSION, PHYSIOLOGY, BLOCKADE, PROTEIN, DA2

ID: 2004363