Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

de Vries, R. H. & Roelfes, G., 19-Aug-2020, In : Chemical communications (Cambridge, England). 56, 75, p. 11058-11061 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

We report the efficient and selective Cu(ii)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).

Original languageEnglish
Pages (from-to)11058-11061
Number of pages4
JournalChemical communications (Cambridge, England)
Issue number75
Publication statusE-pub ahead of print - 19-Aug-2020

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