Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteinsde Vries, R. H. & Roelfes, G., 19-Aug-2020, In : Chemical communications (Cambridge, England). 56, 75, p. 11058-11061 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
We report the efficient and selective Cu(ii)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).
|Number of pages||4|
|Journal||Chemical communications (Cambridge, England)|
|Publication status||E-pub ahead of print - 19-Aug-2020|