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Cross-modal plasticity preserves functional specialization in posterior parietal cortex

Lingnau, A., Strnad, L., He, C., Fabbri, S., Han, Z., Bi, Y. & Caramazza, A., Feb-2014, In : Cerebral Cortex. 24, 2, p. 541-549 9 p.

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  • Angelika Lingnau
  • Lukas Strnad
  • Chenxi He
  • Sara Fabbri
  • Zaizhu Han
  • Yanchao Bi
  • Alfonso Caramazza

In congenitally blind individuals, many regions of the brain that are typically heavily involved in visual processing are recruited for a variety of nonvisual sensory and cognitive tasks (Rauschecker 1995; Pascual-Leone et al. 2005). This phenomenon-cross-modal plasticity-has been widely documented, but the principles that determine where and how cross-modal changes occur remain poorly understood (Bavelier and Neville 2002). Here, we evaluate the hypothesis that cross-modal plasticity respects the type of computations performed by a region, even as it changes the modality of the inputs over which they are carried out (Pascual-Leone and Hamilton 2001). We compared the fMRI signal in sighted and congenitally blind participants during proprioceptively guided reaching. We show that parietooccipital reach-related regions retain their functional role-encoding of the spatial position of the reach target-even as the dominant modality in this region changes from visual to nonvisual inputs. This suggests that the computational role of a region, independently of the processing modality, codetermines its potential cross-modal recruitment. Our findings demonstrate that preservation of functional properties can serve as a guiding principle for cross-modal plasticity even in visuomotor cortical regions, i.e. beyond the early visual cortex and other traditional visual areas.

Original languageEnglish
Pages (from-to)541-549
Number of pages9
JournalCerebral Cortex
Volume24
Issue number2
Publication statusPublished - Feb-2014
Externally publishedYes

    Keywords

  • Adult, Arm, Blindness, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Neural Pathways, Neuronal Plasticity, Occipital Lobe, Parietal Lobe, Proprioception, Visual Perception, Journal Article, Research Support, Non-U.S. Gov't

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